Fig. 8: Characterization of B cells in patients with herpes zoster.

a Three clusters of b cells were displayed according to marker gene expression levels. Uniform manifold approximation and projection (UMAP) presentation of the heterogeneous clusters of peripheral b cells, memory b cells, naïve b cells and plasma cells. b The bar plot shows the relative contributions of three subpopulations by samples, including the HA, HP and RP group. c The heatmap shows the DEGs of b cells between the HAs and herpes zoster patients (HP). d violin plot of subtype-specific marker genes of b cells, including CD19, IGHD, IL4R, CD27, IGHG1, MS4A1, CD38, IGHM and TCL1A. e GO BP enrichment analysis for the DEGs of memory b cell and plasma cells upregulated in HP patients. P value was derived by a hypergeometric test. f GSEA plot for selected pathway positively enriched in b cell cluster. g GSEA plot for selected signaling pathway positively enriched in b cell cluster. h Volcano plot for comparison of HP vs. HA group in b cell cluster. i Representative cytometric gating strategy for identification of b cells. j Proportion of peripheral b cells in HP and HA groups.