Fig. 6: Piezo1 regulates NEC-induced intestinal injury via activating Ca2+ related signaling pathway. | Communications Biology

Fig. 6: Piezo1 regulates NEC-induced intestinal injury via activating Ca2+ related signaling pathway.

From: Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway

Fig. 6

A Volcano plot of differentially expressed genes (|log2(FoldChange)|>1, P value < 0.05) in the control group and NEC group. B, C GO and KEGG annotation of the differentially expressed genes in the control group and NEC group. D Volcano plot of differentially expressed genes (|log2(FoldChange)|>0.585, P value < 0.05). E, F GO and KEGG annotation of the differentially expressed genes from the Piezo1vill KO and Piezo1 fl/fl intestine after NEC induction. G Heatmap of genes participated in the Ca2+ homeostasis in Piezo1vill KO and Piezo1fl/fl groups after NEC induction. H The expression of Ca2+ homeostasis related genes in Piezo1fl/fl and Piezo1vill KO mice with or without NEC induction was verified by qRT-PCR (n = 6 mice). P values were determined by unpaired two-tailed Student’s t test, *P < 0.05; **P < 0.01; ***P < 0.001. Data are mean ± SEM.

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