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Showing 1–7 of 7 results
Advanced filters: Author: Devanjali Dutta Clear advanced filters

  • Suitable in vitro models allowing to assess Plasmodium liver stage development are still limited. Here, Yang et al. show that hepatocytes derived from human hepatocyte organoids (HepOrgs) can support P. falciparum development. This allowed for the identification and validation of the importance of the host factor, scavenger receptor B1 (SRB1), in parasite development.

    • Annie S. P. Yang
    • Devanjali Dutta
    • Robert W. Sauerwein
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The parasite Cryptosporidium can infect human organoids, where it replicates and completes its complex lifecycle. This new in vitro system enables the study of parasite development within the host and associated immune responses.

    • Inha Heo
    • Devanjali Dutta
    • Hans Clevers
    Research
    Nature Microbiology
    Volume: 3, P: 814-823

  • Miniature gut tubes grown in vitro from mouse intestinal stem cells are perfusable, can be colonized with microorganisms and exhibit a similar arrangement and diversity of specialized cell types to intestines in vivo.

    • Mikhail Nikolaev
    • Olga Mitrofanova
    • Matthias P. Lutolf
    Research
    Nature
    Volume: 585, P: 574-578

  • Patel et al. report that Drosophila intestinal stem cell tumours are generated by stress- and EGFR-signalling, followed by extrusion of neighbouring enterocytes, enterocytic cytokine expression and paracrine signalling for tumour growth.

    • Parthive H. Patel
    • Devanjali Dutta
    • Bruce A. Edgar
    Research
    Nature Cell Biology
    Volume: 17, P: 1182-1192

  • This protocol comprises various methods to coculture organoids (particularly human small intestinal and colon organoids) with microbes, including microinjection into the lumen and periphery of 3D organoids and exposure of organoids to microbes in a 2D layer.

    • Jens Puschhof
    • Cayetano Pleguezuelos-Manzano
    • Hans Clevers
    Protocols
    Nature Protocols
    Volume: 16, P: 4633-4649