Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–50 of 1603 results
Advanced filters: Author: Jonathan Chen Clear advanced filters
  • Ambient air pollution exposure in early childhood has been linked to infection risk but the mechanism is unclear. Here, the authors investigate the association between air pollution-linked proteomic profiles in pregnancy and infection in early childhood using data from Denmark and Sweden.

    • Nicklas Brustad
    • Tingting Wang
    • Bo Chawes
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Therapeutic T cells engineered to recognize tumour antigens are frequently short-lived and acquire unfavourable phenotypes in tumours. Here authors show that a tandem approach using autologous T cells targeted against the tumour antigen NY-ESO-1, followed by transfer of hematopoietic stem cells with the same specificity in the clinical trial NCT03240861, provides a safe and promising therapeutic option.

    • Theodore S. Nowicki
    • Nataly Naser Al Deen
    • Antoni Ribas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Black phosphorus (BP) is considered a promising van der Waals material for the realization of mid-infrared detectors. Here, the authors report the realization of flexible infrared imagers based on solution-processed BP photodiodes on thin plastic substrates, showing long term stability and mechanical robustness.

    • Theodorus Jonathan Wijaya
    • Naoki Higashitarumizu
    • Ali Javey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

    • Camille S. Delavaux
    • Thomas W. Crowther
    • Daniel S. Maynard
    ResearchOpen Access
    Nature
    Volume: 621, P: 773-781
  • This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

    • Maria Koromina
    • Ashvin Ravi
    • Niamh Mullins
    ResearchOpen Access
    Nature Neuroscience
    P: 1-11
  • A common but untested expectation is that nutrient enrichment causes biotic homogenization. However, a globally standardized nutrient addition experiment in grasslands shows proportionally similar species loss across scales and no biotic homogenization after up to 14 years of treatment.

    • Qingqing Chen
    • Shane A. Blowes
    • Jonathan M. Chase
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • Here the authors show that PD-1 controls coinhibitory receptor expression by Treg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing Treg function and tumor escape, suggesting that CD30 might be a therapeutic target in cases of anti-PD-1 resistance.

    • Jing Xuan Lim
    • Tegan McTaggart
    • Shoba Amarnath
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1074-1086
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • Oxidized mitochondrial DNA can be released into cytoplasm activating the Nlrp3 inflammasome resulting in its extracellular release. Here the authors show that only this oxidized form can induce autoantibody production by uptake into plasmacytoid dendritic cells, which then produce interleukin-21 to differentiate naive T cells into TFH cells.

    • Hongxu Xian
    • Kosuke Watari
    • Michael Karin
    Research
    Nature Immunology
    Volume: 26, P: 1168-1181
  • An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.

    • Binbin Xu
    • Dafa Chen
    • Haiping Xia
    Research
    Nature
    Volume: 641, P: 106-111
  • Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

    • Iris Hordijk
    • Lourens Poorter
    • Thomas W. Crowther
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more than 21,000 monozygotic twins—the largest genetic study of monozygotic twin differences to date.

    • Elham Assary
    • Jonathan R. I. Coleman
    • Robert Keers
    ResearchOpen Access
    Nature Human Behaviour
    P: 1-14
  • The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

    • Tim H. H. Coorens
    • Ji Won Oh
    • Yuqing Wang
    Reviews
    Nature
    Volume: 643, P: 47-59
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

    • Silvia Buonaiuto
    • Franco Marsico
    • Vincenza Colonna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Comparing to Gossypium hirsutum, G. barbadense cotton lines have superior fiber quality but lower fiber yield. Here, the authors construct pangenome using 12 newly assembled G. barbadense genomes and 17 publicly tetraploid cotton genomes and reveal yield- and fiber-related diversity and interspecific gene flow.

    • Qingying Meng
    • Peihao Xie
    • Daojun Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Using a spatial reasoning task in mice, the authors show that retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming information to resolve ambiguities.

    • Jakob Voigts
    • Ingmar Kanitscheider
    • Mark T. Harnett
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 1293-1299
  • Jonathan Park’s scientific interests changed after caring for a person with cancer. He ended up bidding an amicable farewell to Mark Gerstein, a supportive supervisor who had taught him a lot.

    • Jonathan Park
    • Mark Gerstein
    Comments & Opinion
    Nature
  • Some cancer patients first present with metastases where the ___location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

    • Jingxuan Bao
    • Junhao Wen
    • Li Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss is linked to reduced myelinating oligodendrocytes, an expansion of neuropilin-2⁺ oligodendrocytes and a maladaptive stress response in astrocytes.

    • Siling Du
    • Yingyue Zhou
    • Marco Colonna
    Research
    Nature Immunology
    Volume: 26, P: 1198-1211
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

    • Vinayak Bhandari
    • Constance H. Li
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Aurora, a new large-scale foundation model trained on more than one million hours of diverse geophysical data, outperforms operational forecasts in predicting air quality, ocean wave dynamics, tropical cyclone tracks and high-resolution weather.

    • Cristian Bodnar
    • Wessel P. Bruinsma
    • Paris Perdikaris
    ResearchOpen Access
    Nature
    Volume: 641, P: 1180-1187