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Shi and colleagues present a spatial microfluidic holographic integrated platform for label-free, high-dimensional analysis of cancer heterogeneity, achieving very high accuracy in classifying cancer types, breast cancer subtypes, and blood cells.

The quasi-two-dimensional antiferromagnet Co_1/3NbS₂ was recently reported to have a significant anomalous Hall effect. However, its controversial spin configuration has presented challenges in understanding the physical mechanism behind the AHE. Here, through an array of experimental probes, Gu, Peng and coauthors verify an intrinsic k-space Berry curvature as origin of the spontaneous Hall effect, and elucidate the ___domain-related magnetic reversal behaviours.

Chemical modifications in DNA enable hidden messages for secure data transmission. Here, authors develop DeepSME, a nanopore sequencing and deep-learning framework that conceals data into DNA using 5-hydroxymethylcytosine and enables single-molecule private communication.

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

Plant roots are exposed to a diverse range of soil-dwelling microbial “friends” and “foes.” Here, via single-nucleus RNA-seq, the authors reveal cell type-specific responses to beneficial and pathogenic microbes in roots and identify regulators of root-microbiome interactions.

Drug exposure during pregnancy lacks sufficient fetal safety information world-widely. Here, the authors report the establishment a multi-center birth cohort to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes.

Middle-aged obesity, marked by excessive fat accumulation, is closely linked to DNA damage. Here, the authors show that the DNA repair enzyme Eepd1, primarily expressed in adipose tissue, in its myristoylated form, promotes lipolysis and thermogenesis by activating PKA to combat obesity.

DNA is a promising medium for data storage but requires efficient sequencing methods for real-time data retrieval. Here, authors introduce Composite Hedges Nanopores (CHN), a nanopore-based codec scheme that improves sequencing efficiency and data accuracy, supporting real-time data retrieval.

Two-dimensional magnetic semiconductors hold promise for spin- and valleytronic applications. Here, the authors report the realization of light helicity detectors based on graphene/CrI₃ van der Waals heterostructures, exhibiting a photocurrent behaviour determined by the magnetic state of CrI₃.

Achieving CO oxidation at room temperature is significant for gas purification but remains challenging to perform. Here, the authors report design of graphene-isolated Pt from cobalt-nickel nanoparticles for efficiently catalytic CO oxidation in an oxygen-rich atmosphere.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Here the authors report the results of a phase 1b trial of the liposomal irinotecan HE072 in patients with metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy.

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

The authors introduce the concepts of Robo-Matter and Robot-Matter duality, using magnetic spinner micro-robots. A wide range of functionalities and applications beyond the capability of both traditional inert and active materials is enabled.

Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

Single-nucleus transcriptomes uncover cell type-specific gene reprogramming in response to nod factors in Medicago, including a defence response at 30 min, which largely returned to normal at 6 h. The results reveal that MtFER interacts with LYK3 and regulates rhizobial symbiosis.

Comparative analysis using a high quality genome from 29 reconstructed ancestral chromosomes of Amazon sailfin catfish reveals gene expansions in immunity, neural, and collagen pathways that may be linked to invasion success.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

The interfaces in perovskite solar cells are critical to the device performance. Li et al. tune the bond strength of the interfacial molecule with the perovskite and the electron transport layer, increasing the power conversion efficiency of the cells.

The large low-shear-velocity anomalies in the deep lower mantle below 2300 km depth may relate to H₂O-induced ferrous iron stability in bridgmanite, according to laser-heated diamond anvil cell experiments.

The bacterial pathogen Ralstonia solanacearum secretes endonuclease RuvC, which degrades mature biofilm by targeting the lattice formed by cruciform extracellular DNA. This helps bacterial dispersal, pathogen spread in plant xylem and virulence.

MnBi₂Te₄ and Bi₂Te₃ can form natural superlattices, where the MnBi₂Te₄ layers are separated by multiples of Bi₂Te₃. The combination of these two materials offers a potential platform for the interplay of tunable magnetism and topology. Here, the authors show that MnBi₄Te₇ and MnBi₆Te₁₀ display a complex magnetic ground state with coexisting ferromagnetic and antiferromagnetic domains.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

SsPEIE1 is an essential virulence factor of Sclerotinia sclerotiorum. SsPEIE1 interacts with the key immune factor AtHIR4 and inhibits AtHIR4 oligomerization-mediated immune responses in Arabidopsis, thereby promoting S. sclerotiorum infection.

PXR regulates glycolipid metabolism, but the role of intestinal PXR in metabolic diseases remains unknown. Here, the authors show the intestinal-selective PXR activation regulates B3galt5 expression and maintains metabolic homeostasis via regulating the intestinal mucus barrier.

Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment.

The conserved BAR ___domain protein FAM92A1 is known to induce membrane curvature. Here, the authors report the crystal structure of its BAR ___domain and perform an extensive characterization of the brain and behavior of FAM92A1 knockout mice.

The clinical benefits of chimaeric antigen receptor (CAR) T therapy are limited by ‘on-target, off-tumour’ effects. In this study, the authors describe a strategy that promotes the recognition of antigen on tumour, but not normal, cells by combining affinity tuning with inducible interleukin-12 expression.

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

By overcoming the limited solubility of other lighter components in aluminum using high pressure and high temperature, a low-density, high specific strength, and single-phase aluminum-based complex concentrated alloy is developed.

Mutations in LRRK2 can cause Parkinson's disease. The authors create a transgenic mouse model of LRRK2 that recapitulates several cardinal features of the disease.

TCP1 promotes tumour progression by disrupting the degradation of the oncogene c-Myc in the context of hepatocellular carcinoma and pancreatic ductal adenocarcinoma.

N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade.

Mycoviruses are obligate parasites of fungi. Here, Hai et al. show that mycoviruses can induce hypovirulence in the fungus Sclerotinia, and plants infected by Sclerotinia facilitate the transmission of these mycoviruses, thereby helping the plants defend against Sclerotinia.