Nature Search

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons

Sissel Ida Schmidt
Justyna Okarmus
Morten Meyer

ResearchOpen Access21 Jun 2025

npj Parkinson's Disease

Volume: 11, P: 1-15

Non-averaged single-molecule tertiary structures reveal RNA self-folding through individual-particle cryo-electron tomography

Using cryogenic electron tomography (cryo-ET) and individual-particle cryo-electron tomography (IPET), non-averaged ternary structures of individual RNA origami 6HBC particles were determined, allowing observation of structural diversity and self-folding dynamics during the maturation process after transcription.

Jianfang Liu
Ewan K. S. McRae
Gang Ren

ResearchOpen Access21 Oct 2024

Nature Communications

Volume: 15, P: 1-18

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

In breast cancer, the immune infiltration of the tumour associates with clinical outcome. Here, the authors infer immune context based on gene expression data and identify a new independent subtype linked to pro-tumorigenic immune infiltration.

Xavier Tekpli
Tonje Lien
Vessela N. Kristensen

ResearchOpen Access03 Dec 2019

Nature Communications

Volume: 10, P: 1-14

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie

ResearchOpen Access17 May 2023

Nature

Volume: 617, P: 764-768

Radiocarbon dating of the Shroud of Turin

P. E. Damon
D. J. Donahue
M. S. Tite

Research16 Feb 1989

Nature

Volume: 337, P: 611-615

The conceptual structure of human relationships across modern and historical cultures

Cheng et al. explore the universality and cultural variability in how people understand human relationships, revealing a five-dimensional framework for relationship concepts across both modern and ancient societies.

Xi Cheng
Haroon Popal
Yin Wang

Research13 Mar 2025

Nature Human Behaviour

Volume: 9, P: 1162-1175

Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages

Macrophages drive inflammation associated with severe COVID-19 but it is less clear whether they can be infected. Here, the authors show efficient antibody-mediated infection of primary macrophages by SARS-CoV-2, leading to cell fusion, de novo virus production and a potent cytokine response.

Suzanne Pickering
Harry Wilson
Stuart J. D. Neil

ResearchOpen Access30 Dec 2024

Nature Communications

Volume: 15, P: 1-17

Engagement and attrition in digital mental health: current challenges and potential solutions

Katharine A. Smith
Thomas Ward
Andrea Cipriani

ResearchOpen Access02 Jul 2025

npj Digital Medicine

Volume: 8, P: 1-9

Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure

Felix Forsberg
Toralph Ruge
Per Swärd

ResearchOpen Access23 Apr 2025

Scientific Reports

Volume: 15, P: 1-10

Effect of Streptomycin on Various Enzymes Responsible for Syntheses and Degradations of Higher Saccharides

S. A. BARKER
E. J. BOURNE
R. B. WARD

Research29 Jan 1955

Nature

Volume: 175, P: 203-204

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single HeLa cells.

Zilu Ye
Pierre Sabatier
Jesper V. Olsen

ResearchOpen Access16 Jan 2025

Nature Methods

Volume: 22, P: 499-509

Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

Nikolay S. Markov
Ziyou Ren
Brian White

Research13 Aug 2024

Nature Immunology

Volume: 25, P: 1607-1622

Minute virus of mice inhibits cell transformation by simian virus 40

S. Mousset
J. Rommelaere

Research09 Dec 1982

Nature

Volume: 300, P: 537-539

Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis

Antineutrophil cytoplasmic antibody (ANCA) is currently treated with broad-spectrum immune suppressive drugs. Here the authors decipher inflammatory niches in the kidney of patients with ANCA-GN by combining spatial and single-cell transcriptomics to identify ustekinumab as a promising treatment option and successfully treat four ANCA-GN patients.

Jonas Engesser
Robin Khatri
Ulf Panzer

ResearchOpen Access19 Sept 2024

Nature Communications

Volume: 15, P: 1-12

Genetic links between ovarian ageing, cancer risk and de novo mutation rates

Analyses focusing on protein-truncating variants from 106,973 women from in the UK Biobank identify variants in genes that reinforce the link between reproductive lifespan in women and cancer risk in both sexes.

Stasa Stankovic
Saleh Shekari
Anna Murray

ResearchOpen Access11 Sept 2024

Nature

Volume: 633, P: 608-614

Systematic identification of post-transcriptional regulatory modules

RNA binding proteins (RBPs) regulate various RNA processes, yet their interactions remain poorly understood. Here, authors generate a comprehensive map of RBP interactions using multimodal data, uncovering context-specific functions and revealing complex post-transcriptional regulatory networks.

Matvei Khoroshkin
Andrey Buyan
Hani Goodarzi

ResearchOpen Access09 Sept 2024

Nature Communications

Volume: 15, P: 1-21

Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023

Human infections with swine-origin influenza A viruses occur sporadically. Here, the authors describe the genomic and epidemiological characteristics of eight cases detected in southern Brazil between 2020 and 2023 and find close links to isolates from pigs, suggesting limited human-to-human transmission.

Paola Cristina Resende
Dennis M. Junqueira
Marilda M. Siqueira

ResearchOpen Access30 Dec 2024

Nature Communications

Volume: 15, P: 1-12

Annual and sub-seasonal dynamics of a rapidly eroding permafrost coastline along the Beaufort Sea in northern Alaska

Melissa K. Ward Jones
Benjamin M. Jones
Diana Bull

ResearchOpen Access05 Jun 2025

Scientific Reports

Volume: 15, P: 1-16

Stimulation of Biosynthesis of Glyceride

G. HÜBSCHER
D. N. BRINDLEY
B. SEDGWICK

Research01 Nov 1967

Nature

Volume: 216, P: 449-453

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

CAR and PXR receptors are known to regulate metabolism, however, there is no dual human ligand suitable for therapy. Here, the authors show a CAR agonist/PXR antagonist, MI-883, which regulates cholesterol/bile acid homeostasis by leveraging CAR and PXR activations in plasma cholesterol regulation.

Jan Dusek
Ivana Mejdrová
Petr Pavek

ResearchOpen Access06 Feb 2025

Nature Communications

Volume: 16, P: 1-21

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Here, Brotherton and colleagues sequence 39 mitochondrial genomes from ancient human remains. They track population changes across Central Europe and find that the foundations of the European mitochondrial DNA pool were formed during the Neolithic rather than the post-glacial period.

Paul Brotherton
Wolfgang Haak
Janet S. Ziegle

Research23 Apr 2013

Nature Communications

Volume: 4, P: 1-11

Stratospheric trace gases in the spring 1986 Antarctic atmosphere

C. B. Farmer
G. C. Toon
L. L. Lowes

Research10 Sept 1987

Nature

Volume: 329, P: 126-130

The Myoglobin Molecule

HELEN SCOULOUDI

Research07 Feb 1959

Nature

Volume: 183, P: 374-376

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

In this phase IV trial, the authors assessed antibody responses to multiple vaccines in the same individuals of different age groups and show that the responsiveness to different vaccines was highly variable but that a small group of older male adults responded low to multiple vaccines.

Reviewer recognition:

Marieke van der Heiden
Sudarshan Shetty
Debbie van Baarle

ResearchOpen Access04 Aug 2024

Nature Communications

Volume: 15, P: 1-13

Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

Liudmila Kulakova
Kiki H. Li
Thomas R. Fuerst

ResearchOpen Access11 Jun 2025

npj Vaccines

Volume: 10, P: 1-17

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans

Decoding the content of extracellular vesicles (EVs) is key to understanding cell communication. Nikonorova et al. used targeted proximity labeling to uncover polycystin EV cargo and cargo-loading mechanisms in C. elegans.

Inna A. Nikonorova
Elizabeth desRanleau
Maureen M. Barr

ResearchOpen Access03 Apr 2025

Nature Communications

Volume: 16, P: 1-18

circGIGYF1 inhibits stemness and metastasis in colorectal cancer by promoting WWP2-HOXD13 interaction to regulate β-catenin signalling

circGIGYF1 inhibits colorectal cancer stemness and metastasis by promoting HOXD13 ubiquitination via WWP2, thereby suppressing Wnt/β-catenin pathway through decreased CTNNB1 expression, revealing a novel therapeutic target for colorectal cancer.

Bin Zhao
Jiacheng Li
Shuxia Ma

ResearchOpen Access01 Jul 2025

Communications Biology

Volume: 8, P: 1-17

Measuring dynamic social contacts in a rehabilitation hospital: effect of wards, patient and staff characteristics

Audrey Duval
Thomas Obadia
Isabelle Villain

ResearchOpen Access26 Jan 2018

Scientific Reports

Volume: 8, P: 1-11

Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing

A deleterious mutation in the tomato transcription factor SSP2 was enriched during domestication. Repairing the deleterious mutation in cultivated tomato by base editing leads to compact growth and early fruit yield.

Anna N. Glaus
Marion Brechet
Sebastian Soyk

Research02 Jan 2025

Nature Genetics

Volume: 57, P: 231-241

Regeneration of Prothrombin Activity by Plasma Albumin and Globulin Fractions

B. C. DAS

Research18 Aug 1962

Nature

Volume: 195, P: 668-670

Radioimmunoassay of Angiotensin in Human Plasma

MICHEL B. VALLOTTON
LOT B. PAGE
EDGAR HABER

Research01 Aug 1967

Nature

Volume: 215, P: 714-715

Long-Period Pulsations of Auroral-Zone X-Rays

H. TREFALL
S. L. ULLALAND

Research01 Dec 1964

Nature

Volume: 204, P: 1148-1150

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

This study reports unexpected structural diversity in computationally designed protein assemblies due to subunit flexibility. Fixing flexibility in one design restores the intended architecture, suggesting a strategy to design dynamic assemblies.

Alena Khmelinskaia
Neville P. Bethel
Neil P. King

ResearchOpen Access26 Feb 2025

Nature Structural & Molecular Biology

Volume: 32, P: 1050-1060

Global biogeographic regions for ants have complex relationships with those for plants and tetrapods

In this study, the authors delineate a global biogeographic map for ants based on their distributions and phylogenetic relationships. They show that current biogeographic maps based on tetrapod groups fail to capture important regions for biodiversity shared by insects and plants, which are both known to possess strong ecological and evolutionary ties.

Runxi Wang
Jamie M. Kass
Benoit Guénard

ResearchOpen Access05 Jul 2024

Nature Communications

Volume: 15, P: 1-11

Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer

The integration of human papillomavirus (HPV) drives HPV-positive head and neck squamous cell carcinoma (HPV⁺ HNSCC). Here, the authors perform genomic analysis to investigate HPV integration in patients with HPV⁺ HNSCC, identifying intratumor heterogeneity and biased distribution of HPV integration.

Noah Sasa
Toshihiro Kishikawa
Hidenori Inohara

ResearchOpen Access26 Jan 2025

Nature Communications

Volume: 16, P: 1-22

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Duration of infectious SARS-CoV-2 shedding is an important measure for improved disease control. Here, the authors use virus cultures of respiratory tract samples from COVID-19 patients and observe a median shedding duration of 8 days and a drop below 5% after 15,2 days post onset of symptoms.

Jeroen J. A. van Kampen
David A. M. C. van de Vijver
Annemiek A. van der Eijk

ResearchOpen Access11 Jan 2021

Nature Communications

Volume: 12, P: 1-6

Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort

Renal cell carcinoma (RCC) subtypes are associated with different molecular alterations and clinical outcomes, but they need to be characterised in diverse cohorts. Here, the authors perform genomic, transcriptomic, and epigenomic profiling in a large cohort of Japanese RCC cases, and identify epi-subtypes associated with a particular immune environment.

Akihiko Fukagawa
Natsuko Hama
Tatsuhiro Shibata

ResearchOpen Access16 Dec 2023

Nature Communications

Volume: 14, P: 1-15

Cluster analysis reveals the clinical spectrum of Erdheim-Chester disease

Michelangelo Tesi
Francesco Pegoraro
Julien Haroche

Research28 May 2025

Leukemia

P: 1-10

G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD

In humans, ADPKD can develop from “second hit” mutations in the PKD1 gene. Here, the authors show that human PKD1 contains guanine quadruplex structures that cause mutagenic double stranded breaks.

Agata M. Parsons
Seth Byrne
Erik D. Larson

ResearchOpen Access02 Jan 2025

Nature Communications

Volume: 16, P: 1-9

The scaffolding function of LSD1 controls DNA methylation in mouse ESCs

This study suggests a mechanism by which LSD1 controls DNA methylation in mouse ESCs, independently of its lysine demethylase activity. The demethylase-independent function of LSD1 regulates the DNMT1 and UHRF1 protein stability through interaction with USP7 and HDAC1.

Sandhya Malla
Kanchan Kumari
Francesca Aguilo

ResearchOpen Access05 Sept 2024

Nature Communications

Volume: 15, P: 1-24

Measurement of the Neutron Spectrum from Zeta

B. ROSE
A. E. TAYLOR
E. WOOD

Research14 Jun 1958

Nature

Volume: 181, P: 1630-1632

Amino-Acid Composition of the Proteins of Barley Leaves in Relation to the Mineral Nutrition and Age of Plants

B. P. PLESHKOV
L. FOWDEN

Research23 May 1959

Nature

Volume: 183, P: 1445-1446

Morphology of Palaeospondylus shows affinity to tetrapod ancestors

Detailed structural analysis of Palaeospondylus gunni from the Middle Devonian period shows strong resemblance to Eusthenopteron and Panderichthys, indicating that it was a sarcopterygian and most probably a stem-tetrapod.

Tatsuya Hirasawa
Yuzhi Hu
Shigeru Kuratani

Research25 May 2022

Nature

Volume: 606, P: 109-112

Temporal stratification of amyotrophic lateral sclerosis patients using disease progression patterns

The authors proposed ClusTric, a temporal stratification approach to find disease progression groups. Applied to Amyotrophic Lateral Sclerosis, the method identifies four progression groups with distinguished characteristics.

Daniela M. Amaral
Diogo F. Soares
Helena Aidos

ResearchOpen Access08 Jul 2024

Nature Communications

Volume: 15, P: 1-14

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan

ResearchOpen Access18 Feb 2025

Nature Genetics

Volume: 57, P: 694-705

A spatial human thymus cell atlas mapped to a continuous tissue axis

A quantitative morphological framework for the human thymus reveals the establishment of the lobular cytokine network, canonical thymocyte trajectories and thymic epithelial cell distributions in fetal and paediatric thymic development.

Nadav Yayon
Veronika R. Kedlian
Sarah A. Teichmann

ResearchOpen Access20 Nov 2024

Nature

Volume: 635, P: 708-718

Innovative technologies to address neglected tropical diseases in African settings with persistent sociopolitical instability

Countries in Africa facing sociopolitical instability also bear a high burden of neglected tropical diseases (NTDs). Here, the authors explore the potential of health technologies to address NTDs through a systematic literature review.