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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populations in scattering conditions.

Nodes in a quantum network must be able to interface with photonic qubits as well as perform local quantum computations. The quantum node device presented here is capable of storing quantum information and correcting bit-flip errors.

This study employs time-lapse single-nucleus RNA sequencing in Arabidopsis seedlings, revealing distinct circadian rhythms in specific cell types and identifying ABF1 as a regulator that shortens the circadian period.

Sustainable management of dissolved organic matter (DOM) is essential for advancing organic waste treatment towards resource-oriented processes, but the molecular complexity of DOM hinders the understanding of the underlying biochemical processes. Here, the authors use ultra-high resolution mass spectrometry to explore the molecular transformation of DOM in anaerobic digestion.

Land plants diverged from streptophyte algae around 460 million years ago. Marine Charophyceae fossils from the Upper Ordovician confirm that morphological innovations key to the evolution of terrestrial flora predate the emergence of land plants.

The authors reveal a complex polarization network in twisted bilayer h-BN, featuring edge polarization topology and sliding ferroelectricity, driven by the interplay of ferroelectric and piezoelectric effects.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Transition-metal-catalyzed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity. Here, the authors report a Cu(I)-catalyzed asymmetric radical 1,2-carboalkynylation of two different terminal alkynes and alkyl halides with chemo-, regio-, and stereoselectivity.

Wang, Wang, Pan and colleagues uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, phase separation and stimulates downstream innate immune signalling.

Manipulation of controllable polarization evolutions is a big challenge. The authors fabricate the irregular moirés, identifying three distinct types of moiré domains with different patterns, modulating them by external mechanical force disturbing.

For bioinspired structural materials, integral preparation of multiscale structures remains challenging. The authors report a hierarchical strategy to assemble multiple micro-nano units to complex multiscale structures integrally synchronously.

A chemical bonding engineering strategy is proposed in this work to realize the improvement of dielectric performance. A colossal permittivity of 2.37 × 10⁵ and a low loss of 0.005 are ultimately achieved in high-entropy CaTiO₃-based ceramics.

Water in the mantle transition zone beneath Northeast Asia is sourced from the Earth’s surface and introduced by the subducted Pacific slab, according to a study of potassium isotopes from Cenozoic volcanics.

Wildfires are becoming increasingly frequent in several regions around the world due to climate change, posing serious health risks, especially for respiratory diseases. This study examines the respiratory health risk and burden of wildfire-specific PM_2.5 pollution across eight countries and territories.

Spontaneous parthenogenesis in sunflower has been used to develop a scalable doubled haploid breeding system.

The explanation of maintenance for a diachronous late Ediacaran ice age remains unclear. Here, the authors use climate and weathering models to find that true polar wander could increase weathering rates and sustain a continuous late Ediacaran ice age.

Near-edge plasma treatment of Hf0.5Zr0.5O2 capacitors results in dielectric permittivity of 921, stored charge density of 349 μC/cm2, and energy density of 584 J/cm3 when the material’s ferroelectricity abruptly disappears after polarization fatigue.

A multi-level ordered structure strategy mimicking biological multi-structural features, concurrently unlocks multiple physical property limits. This new paradigm transcends traditional compositional design strategies to break performance bottleneck.

A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

Three-dimensional multiplane structured illumination microscopy, combining three-beam interference, multiplane detection and a synergistically evolved reconstruction algorithm, enables 3D imaging at rates of up to 11 volumes per second in live cells with lateral and axial spatial resolutions of 120 and 300 nm, respectively.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Soil viruses could have a disproportionate role in ecosystem functioning. Here, the authors combine multiple data and approaches to explore diversity and distribution of P-acquisition genes encoded by soil bacteriophages, suggesting the importance of viral auxiliary metabolism for nutrient cycling.

An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Gestational diabetes milletus (GDM) may have impairments on offspring health. Here, the authors suggest that the increase of EZH2 is an important reason for the disrupted DNA methylome in oocytes exposed to GDM, which may be associated with the transgenerational inheritance of the metabolic disorders.

Halide perovskites are promising for next generation photovoltaic technology but their environmental impact has not been fully evaluated. Here Li et al. show that the lead from perovskites is ten times more dangerous than lead-containing electronics while tin perovskites are much less bioavailable.

How pulsed electrolysis impacts the electrochemical CO2 reduction reaction remains unclear. Here, authors present a molecular-level picture on the complex interactions between cathode surfaces, adsorbates, and local reaction environment to elucidate the promotional effect of pulsed electrolysis.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.