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Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

An icing forecast hydrogel device encapsulating ice-nucleating proteins colorimetrically predicts ice formation with high accuracy. The device successfully activated a wind turbine deicing system 70 min before ice accumulation.

Diatoms are crucial marine microorganisms, but the molecular mechanisms underlying their temperature tolerance remain unclear. This study identifies the heat shock transcription factor PtHSF2 as a key regulator of thermal tolerance and cell size plasticity in Phaeodactylum tricornutum, revealing its role in gene regulation and stress response.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature of steric hindrance at ortho-aryl substituents. Herein, the authors report the synthesis of diverse atropisomeric arylpyrroles with 1,2-diaxes, and C–C and C–N axes via a remote stereocontrol strategy.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonization and outgrowth of medulloblastoma cells in the leptomeninges.

The complexity of matching ABO blood groups presents a formidable barrier to successful transplantation. Here, the authors show that an enzymatic converted type B kidney was transplanted into a type O brain-dead recipient without hyperacute rejection.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Ammonia and nitric acid are key platform chemicals to introduce nitrogen into organic molecules, however gaseous N₂ would be a more direct and available source of nitrogen. Here, the authors report a direct catalytic nitrogenation to afford valuable arylamines and N-heterocycles from organohalides using dinitrogen (N₂) as the nitrogen source.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Heteroaryl ketones are ubiquitous molecular scaffolds but seldom used as synthetic precusors. Here, the authors develop an acyl transfer-annulation to convert heteroaryl ketones to N-fused heterocycles, which are prevalent in bioactive molecules.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Hypoglycemia is a serious and potentially life-threatening condition for people with insulin dependent diabetes, but preventative hypoglycemia therapies are elusive. Here, the authors report the use of catechol and boronic acid chemistry to design a self-crosslinkable hydrogel-based microneedle patch that delivers Zinc-Glucagon at low glucose levels and prevents insulin-induced hypoglycemia.

HD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection.

The authors find multiple topological transitions and a composite topological phase by two mutually exclusive topological orders, strong topological order and high-order topological order, in a quasi-1D system.

Transition metal oxides constitute a promising class of catalysts for the oxygen reduction reaction, but they are found generally to be less active than Pt. Now, computational analyses and high-throughput experiments are used to understand the reasons behind the lower activity, and strategies to improve them are proposed.

Ferroptosis is crucial in tumor growth, metastasis, and cancer therapy response. Here, the authors reveal that reversible palmitoylation of GPX4 by ZDHHC20 and APT2 regulates ferroptosis sensitivity, offering a potential target for therapeutic intervention.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

Jiang et al. identify Pax as a key regulator of Drosophila midgut homeostasis. Pax coordinates the Hippo and Notch pathways to control the proliferation and differentiation of intestinal stem cells (ISCs), ensuring homeostasis of midgut.

TP63 is a master regulator transcription factor in squamous cell carcinomas (SCCs). Here the authors report that TP63 suppresses IFNγ signaling in SCC tumors and that its inhibition is associated with enhanced anti-tumor immunity and response to anti-PD1.

Hao, Shen and colleagues identify and characterize two distinct types of myeloid–B cell interaction that may signal solid tumour-induced immunosuppression and can correlate with complete responses to immunotherapy in patients with breast cancer.

The chitosan utilization regulator, ChsR, positively regulates Vibrio cholerae virulence factor expression, which can be inhibited therapeutically by chitosan oligosaccharide administration in mice.

Zhang et al. demonstrate that the smooth muscle-specific deficiency of the mitochondrial NAD⁺ transporter SLC25A51 impairs the biosynthesis of proline and type III collagen and results in thoracic and abdominal aortic aneurysm.

Tang, Zhang, Fang, Zhu et al. identify impaired mitochondrial fusion and biogenesis as a key mechanism underlying NOTCH1-associated aortic pathology and show that correcting mitochondrial loss in mutant mice using repurposed drugs teriflunomide or leflunomide slows the progression of aoropathy.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

The aluminium production process is energy intensive and individual smelters often depend on associated fossil fuel-based captive power units. With detailed global facility-level data, this research highlights the importance of early retirement of fossil fuel plants and retrofitting with inert anodes.

This study maps the single-axon projections of 7,180 hypothalamic peptidergic neurons in male mice and uncovers extensive collateralization, topographic target innervation and modular intra-hypothalamic organization.

Through rational engineering of A3A deaminase, Yang and colleagues have designed CBEs termed haA3A-CBEs, which feature a condensed editing window and minimal off-target effects that are independent of defined sequence contexts and methylation status.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The haplotype-resolved genome of tetraploid modern rose, along with a variation map of 233 wild and cultivated Rosa accessions, reveals the complex genome composition of modern roses and elucidates the genomic bases of their origin and breeding.

The development of giant oligomeric donors to replace batch-varied polymer remains challenging. Here, the authors regulate the assembly behaviour of giant dimeric donors, realizing all-giant-oligomeric-based organic solar cells with promising device efficiency and stability.