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The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

The authors propose a strategy of embedding ultra-weak polar regions in the strong polar fluctuation matrix in (Bi0.5Na0.5)TiO3-based lead-free ceramics to achieve substantial enhancements of energy storage properties.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

A gold catalyst supported on intergrown titanosilicate zeolites enhances propene oxide production by activating oxygen-transfer intermediates more efficiently at Ti interface sites.

Epithelial malfunction is an unmet critical challenge in trachea repair. Here, Chen et al. developed a multiplexed hydrogel to promote tracheal repair with native-like epithelium in pre-clinical models, exhibiting clinical translation potential.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

In this work, Dong and coworkers report a set of benzo[f]quinoline-linked covalent organic frameworks via a one-pot three-component [4 + 2] cyclic condensation reaction which are used as photocatalysts for H₂O₂ production in pure water.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Holmium doping endows upconversion nanoparticles with a dual-reservoir-level mechanism for parallel photon avalanche emission, enabling tunable chromaticity at room temperature, nonlinearity index up to 22 and spatial resolution for multicolour biological imaging down to 78 nm.

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

The diversity and genomic resources of Brassicaceae make it an ideal model for studying karyotype evolution. Here, the authors reconstruct ancestral karyotypes of Camelinodae and Brassicodae, identify cascading fusions, and highlight their stable inheritance and role in evolutionary relationships.

This study shows grey infrastructure (economy-linked) dominates flood control in normal rains. During extremes, its efficacy declines while green infrastructure/topography (less economy-aligned) become crucial for urban flood mitigation.

H₂O₂ is a commodity chemical produced in industry via the anthraquinone process from H₂ and O₂. Now a heterogeneous catalysis approach is presented in which H₂O₂ is synthesized from H₂O and O₂ on defective SnSe nanosheets at ambient conditions.

It has been shown that targeting receptor-interacting protein kinase 1 (RIPK1) can improve response to immune checkpoint inhibitors. Here, using PROTAC technology, the authors report the design and characterization of a RIPK1 degrader, enhancing anti-tumor immunity in preclinical cancer models.

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Nodes in a quantum network must be able to interface with photonic qubits as well as perform local quantum computations. The quantum node device presented here is capable of storing quantum information and correcting bit-flip errors.

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

Evidence is shown for a skyrmion-like texture in the layer polarization of the electronic wavefunctions of a twisted two-dimensional material. This provides support for theories that link this spatial texture to the topological properties.

Aurora, a new large-scale foundation model trained on more than one million hours of diverse geophysical data, outperforms operational forecasts in predicting air quality, ocean wave dynamics, tropical cyclone tracks and high-resolution weather.

Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases are a promising target for antiviral drugs.

The actin cytoskeleton plays crucial roles in pollen development, germination, and tube growth. Here the authors show that PGSL1, an Arabidopsis heat-stable actin binding protein stabilizes actin filaments under high temperatures, preventing denaturation and maintaining F-actin dynamics.

Hybrid necrosis in wheat is caused by the complementary genes Ne1 and Ne2. The underlying mechanism remains enigmatic. Here, Si et al. demonstrated that a genetic interaction between the α/β hydrolase (Ne1) and the NLR immune receptor (Ne2) triggers autoimmune responses, inducing hybrid necrosis.

Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytosine, leading to the derepression of transposable elements and, in certain cases, the activation of nearby genes.

The electrode–aqueous interface is crucial to designing effective electrocatalysts for the hydrogen evolution reaction, which occurs in water electrolysers. Here the authors explore the use of organic overlayers on Pt electrodes, enhancing hydrogen evolution activity in alkaline media by up to 50 times.

Understanding archaeal metabolic gene regulation is technically challenging due to the difficulty of measuring gene expression dynamics in individual archaeal cells. Here, Dong et al. develop a method to quantify the transcriptional dynamics of multiple metabolic genes in single cells of a methanogenic archaeon.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

The low-cost synthesis of high-quality MXenes is crucial for applications, yet challenges remain. The authors report a one-step gas-phase method to fabricate single-phase Ti₂(C/N)Cl₂ with low defects, offering a chance to address these challenges.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

Field experiments demonstrate that the loss of wetland carbon sequestration accounts for the majority of the greenhouse gas footprint arising from aquaculture-driven land-use change.

Here, the authors report the experimental realization of a 3D Wannier-type photonic HOTI, which hosts coexisting self-guided topological surface, hinge, and corner states in a single 3D tight binding-like photonic crystal.

Innate and adaptive immunity are equally important for the anti-tumor response and immunotherapy simultaneously activating both arms could have therapeutic benefits. Here authors show that a composite nanoparticle platform that immobilizes monoclonal antibodies targeting PD-L1, 4- 1BB and NKG2A or TIGIT recruits and activates both NK and CD8 + T cells.

A fundamental objective of genomics is to track variations in gene expression program. Here, authors developed Dyan-vivo-seq, which offers unprecedented insights into temporal RNA dynamics within intricate and dynamic biological systems at single-cell resolution.

Crystallization processes are influenced by the presence of impurities. Colloid experiments now reveal two distinct types of growth mode that depend on the extent to which a crystallizing system can remove impurity particles from its growth front.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

This study found that mGluR5 availability is lower in patients with MDD and increases after treatment, correlating with symptom improvement, highlighting the role of mGluR5 role in MDD pathophysiology and treatment response.

Superoxide oxidizes the iron–sulfur cluster in the DNA demethylase ROS1 and extensively participates in the establishment of active DNA demethylation in plants to maintain stem cell fate.

Here, the authors show how Aurora kinase A (AURKA) employs Rab1a to direct ER remodeling. Activated Rab1A is retained on the ER and directly interacts with the RTN/REEP ER-shaping machinery to promote its oligomerization, eventually triggering an increase of ER complexity during mitosis.

Subwavelength focusing of electromagnetic fields often uses evanescent waves and nanostructures to aid confinement. Here, the authors localize a microwave field to 6 orders of magnitude smaller than the wavelength, by coupling to confined electron oscillations in a hybrid nanowire-bowtie antenna.