Nature Search

Development of an allosteric adhesion GPCR nanobody with therapeutic potential

A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

Yuan Zheng
Dan Jiang
Shiqing Feng
Research15 May 2025
Nature Chemical Biology

P: 1-12
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer

The RNA binding protein hnRNPL is recruited to chromatin by the PIK3CB promoter-transcribed non-coding RNA and forms phase-separated condensates, which activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression.

Fengjiang Qin
Yuya Wang
Ping Yi
ResearchOpen Access24 May 2025
Nature Communications

Volume: 16, P: 1-18
Deciphering a volcano-shaped relationship between radical stability and reticular electrochemiluminescence

Deciphering the relationship between radical stability and electrochemiluminescence performance is important since the stability of electrochemically generated radicals has an impact on the efficiency and durability of excited state generation. Here, the authors describe a volcano shaped relationship via modulating the electron affinity of three acrylonitrile-linked covalent organic frameworks.

Haocheng Xu
Rengan Luo
Kai Xi
ResearchOpen Access24 Feb 2025
Nature Communications

Volume: 16, P: 1-9
Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface

Bone-tendon interface repair is a challenge due to the transition between tissues. Here the authors report on magnetic Janus hydrogel microrobots loaded with dual bioactive ions for controlling cell phenotype and structure to promote healing of the bone-tendon interface in rotator cuff tear reconstruction surgery.

Zichuan Ding
Yongrui Cai
Zeyu Luo
ResearchOpen Access04 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Author Correction: Prime editing using CRISPR-Cas12a and circular RNAs in human cells

Ronghong Liang
Zixin He
Caixia Gao
Amendments and Corrections08 Feb 2024
Nature Biotechnology

Volume: 42, P: 1921-1922
Generative learning assisted state-of-health estimation for sustainable battery recycling with random retirement conditions

Data scarcity and heterogeneity impede the estimation of retired battery capacity. Here, Tao et al. propose a generative learning method that extends measured data space, potentially reducing curation time, cost and facilitating their sustainable reuse and recycling.

Shengyu Tao
Ruifei Ma
Guangmin Zhou
ResearchOpen Access23 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Uncertainty evaluation and model optimization in multi-source reservoir modeling

Pingshan Ma
Chengyan Lin
Shun Wang
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-16
Prime editing using CRISPR-Cas12a and circular RNAs in human cells

Prime editing with CRISPR-Cas12a broadens targeting scope and enables multiplexing.

Ronghong Liang
Zixin He
Caixia Gao
Research10 Jan 2024
Nature Biotechnology

Volume: 42, P: 1867-1875
An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses

Blockade of CD47/SIRPα and CD24/Siglec-10 pathways can promote macrophage-mediated phagocytosis of tumor cells. Here the authors report the design of a peptide-antibody combo-supramolecular in situ assembled CD47 and CD24 bi-target inhibitor that enhances the phagocytic ability of macrophages and improves response to anti-PD-1 in preclinical cancer models.

Weiqi Zhang
Yinghua Zeng
Yanbin Cai
ResearchOpen Access06 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Weak CO binding sites induced by Cu–Ag interfaces promote CO electroreduction to multi-carbon liquid products

Here, the authors demonstrate a Cu-based catalyst with Cu–Ag interfacial sites, which favor oxygenate over alcohol production in CO₂ electroreduction. Near 80% selectivity for multi-carbon liquid products in a 100 cm² membrane electrode assembly electrolyzer is exhibited over 100 h.

Jing Li
Haocheng Xiong
Qi Lu
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-10
Sustainable upcycling of mixed spent cathodes to a high-voltage polyanionic cathode material

Direct recycling of critical battery materials bring promise but a challenge for the mixed cathode chemistries. Here, the authors report a sustainable upcycling approach, transforming degraded LiFePO₄ and Mn-rich cathodes into a high-voltage polyanionic material with an increased energy density and economic value.

Guanjun Ji
Di Tang
Hui-Ming Cheng
ResearchOpen Access14 May 2024
Nature Communications

Volume: 15, P: 1-10
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular ___domain (NICD1) to promote cancer metastasis.

Lei Liu
Tianyu Tao
Han Tian
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-16
Collaborative and privacy-preserving retired battery sorting for profitable direct recycling via federated machine learning

Unsorted retired batteries pose recycling challenges due to diverse cathodes. Here, the authors propose a privacy-preserving machine learning system that enables accurate sorting with minimal data, important for a sustainable battery recycling industry.

Shengyu Tao
Haizhou Liu
Hongbin Sun
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-14
CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis

Ziyun Li
Jia Jiang
Jinzhong Zhao
ResearchOpen Access24 Feb 2025
Bone Research

Volume: 13, P: 1-16
Research on cavitation effect of microtextured array

Yuanyuan Jiang
Zhijun Yan
Haocheng Sun
ResearchOpen Access04 Aug 2022
Scientific Reports

Volume: 12, P: 1-17
Two stage multiobjective topology optimization method via SwinUnet with enhanced generalization

Cheng Xiang
Airong Chen
Haocheng Chang
ResearchOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1-21
Macrophage tracking with USPIO imaging and T2 mapping predicts immune rejection of transplanted stem cells

Wenhui Wang
Zhenyu Liu
Junping Zhen
ResearchOpen Access25 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.

Haocheng Zhou
Qiaosheng Zhang
Jing Wang
ResearchOpen Access14 Sept 2018
Nature Communications

Volume: 9, P: 1-13
Metabolic defects in splenic B cell compartments from patients with liver cirrhosis

Man Huang
Xiaoju Liu
Zheng Zhang
ResearchOpen Access24 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-14
Experimental and numerical study of the mixed lubrication under the action of magnetic ionic liquid additives

Ze Liu
Zhijun Yan
Shengwei Zhang
ResearchOpen Access07 Mar 2024
Scientific Reports

Volume: 14, P: 1-22
Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation

Junjie Lin
Xin Zhang
Renqing Zhao
ResearchOpen Access09 May 2024
Scientific Reports

Volume: 14, P: 1-14
Single-shot compressed optical field topography

Haocheng Tang
Ting Men
Zhengyan Li
ResearchOpen Access02 Aug 2022
Light: Science & Applications

Volume: 11, P: 1-10
Analysis of landscape pattern vulnerability in Dasi river basin at the optimal scale

Haocheng Wang
Lin Wang
Baoli Wei
ResearchOpen Access10 May 2024
Scientific Reports

Volume: 14, P: 1-21
Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression

Haocheng Zhang
Xiaolei Ma
Guofen Qiao
ResearchOpen Access25 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-15

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