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In this work, authors design novel protein condensation inhibitors (PCIs) targeting an allosteric site of cGAS, blocking DNA interactions and phase separation to suppress immune activation, and demonstrate therapeutic potential in inflammatory disease models.

An acid-free atmospheric leaching process extracts 97.4% Ni and 98.8% Co from critical minerals, limits iron dissolution (4.7%), and reduces CO₂ emissions by 59.5%, offering a sustainable alternative for battery-grade metal production.

Phenazine biosynthesis-like ___domain-containing protein (PBLD) and cedrelone play roles in tumor suppression. Here, authors suggest that PBLD and Cedrelone inhibit viral replication via activating the NF-κB-mediated IFN-I signaling response in cells and mice.

To correlate the microstructure of flexible covalent organic frameworks with their flexibility is challenging. Here, the authors visually track the deformation behaviors of single covalent organic framework particles with dark-field microscopy discovering that their flexibility is dictated by the pedal motion around rigid imine bonds.

Phonons at the FeSe/STO interface are imaged at atomic scale, uncovering new optical phonon modes that couple strongly with electrons, shedding light on the microscopic origin of the interfacial EPC and providing insights into achieving superconducting transition temperature enhancement.

This research identifies a regulatory role for the receptor-like kinase FERONIA in Arabidopsis roots, finding that it balances growth and immunity by activating localized immunity in response to bacterial colonization.

De novo genome assembly and analyses of 12 maize FILs provide insights into genomic and phenotypic differentiation of various heterotic groups and the molecular basis of heterosis in maize.

The exact quantification of environmental and human health gains achieved through sustainable nitrogen management is often impaired by real-world data availability. Drawing on an extensive database in China, this study estimates the costs and benefits of combining organic and chemical fertilizers, straw recycling and deep placement of fertilizer.

The NADPH oxidase 2 (NOX2) complex is a main reactive oxygen species (ROS) source during inflammation. Here the authors report that NCF4, a subunit of the NOX2 complex, acts a sensor of ROS levels and regulates NLRP3 and AIM2 inflammasome activation, associated with attenuated colorectal cancer progression.

This work proposes a cracking control strategy using MXene and silver nanowire composite films to achieve a stretchable strain sensor system with high resolution, range, sensitivity, speed, and stability

Atom probe tomography can image chemical composition at the nanoscale, but our understanding of how it images voids, or empty spaces, is still lacking. Here, the authors combine atom probe tomography, scanning transmission electron microscopy, and field-evaporation theory to show how voids are imaged and subsequently measured.

While water splitting electrolysis offers an appealing means to produce H₂ fuel, catalysts show sluggish reaction rate in neutral media. Here, authors utilize hydrogen spillover from oxygen-deficient tungsten oxides to Ru nanoparticles to boost the neutral-pH H₂ evolution performances.

Increased relative abundance of oral bacteria in faecal samples can be explained by the marker hypothesis—their relative increase reflects the depletion of other microbiota members—which has implications for patient outcomes and microbiota-directed therapies.

The interplay between stacking configurations and atom intercalation in van der Waals materials has been rarely characterized at the microscopic level. Here, the authors report an electron microscopy study of stacking-selective self-intercalation in Nb_1+xSe₂ films, showing potential for nanoscale engineering of electronic properties in van der Waals materials and devices.

Animals can fear specific objects with no previous experience. For example, naive mice are innately afraid of cats. Here the authors employed optogenet­ics and behavioral assays to determine the neural circuit mechanisms involved in mediating olfactory cue–induced innate fear in mice.

The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models.

The relatively larger steric hindrance and excessive crystallinity of bromides could lead to undesirable film morphologies. Here, the authors take advantage of bromides and construct small molecule acceptors with stepwise bromination and realize maximum efficiency of 19% in organic solar cells.

The understanding of complex electronic correlation and non-equilibrium atomic interactions is a grand challenge. Here, the authors show that chemical disorder in single-phase concentrated solid solution alloys can lead to reduction in electron mean free path and electrical and thermal conductivity.

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.

Neoadjuvant therapy is recommended for patients with locally advanced breast cancer. Here the authors report the results of a phase 2 clinical trial of oral neoadjuvant therapy with pyrotinib (pan-HER tyrosine kinase inhibitor), letrozole (aromatase inhibitor) and dalpiciclib (CDK4/6 inhibitor) in patients with treatment-naïve and stage II-III triple positive breast cancer.

Ji and colleagues demonstrate that metabolic reprogramming in SCLC underlies chemotherapy resistance, resulting in an actionable dependency on the mevalonate pathway in tumor cells, which can be targeted using statins to revert chemoresistance.

The selective hydrogenation of nitriles to prepare corresponding amines is highly desired in chemistry industry. Here, the authors selectively obtained secondary amines and primary amines over two types of atomically dispersed Pd catalysts supported on the nanodiamond-graphene hybrid support.

Wu et al. optimized the m⁶A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m⁶A methylation in mouse oocytes and early embryos.

Organic solar cells with efficiency greater than 10% are fabricated by incorporating a semiconductor polymer with a deepened valence energy level.

Polymer solar cells are lightweight and may represent a low-cost source of energy, although efficiency still prohibits many practical applications. Here researchers demonstrate polymer solar cells with a certified efficiency of 9.2%. This is achieved by employing an inverted structure that aids photogenerated charge-carrier collection and photon harvesting.

High-performance polymer solar cells are normally processed with halogenated solvents, which are toxic and hazardous. Now, high power-conversion efficiency in bulk-heterojunction devices is achieved by using a non-toxic hydrocarbon solvent through an environmentally friendly processing route.

Previous surveys of global ocean microbial diversity have focused on planktonic microbes. Here, Zhang et al. use metagenomics to study biofilm-forming marine microbes, increasing the known microbial diversity in the oceans by more than 20% and revealing new biosynthetic gene clusters and CRISPR-Cas systems.

Supercontinuum generation can be utilized for light source development. Here the authors demonstrate ultraviolet supercontinuum generation from ions due to strong field ionization and multiphoton resonance effect.

Radiation tolerance is a property determined both by materials structure and defect dynamics. Here authors demonstrate enhancement of radiation tolerance at elevated temperatures in equiatomic single-phase concentrated solid solution alloys and propose an underlying mechanism.

Non-small cell lung cancer manifests as adenocarcinoma and squamous cell carcinoma but tumours of mixed lineage are often found in humans. Here, the authors show that adenocarcinoma can transdifferentiate into squamous cell carcinomas in mice.

The sarpagine-ajmaline-koumine type alkaloids are among the most important groups of monoterpenoid indole alkaloids, having notable biological activity. Here the authors perform divergent syntheses of 14 natural products in this family from a common intermediate.

The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.

Sulfur is abundant in the Universe, but the observed abundance ratio of SH to H₂S doesn’t agree with astrochemical models. The authors measure product state-resolved translational energy spectra of photoproducts in a jet-cooled H₂S beam as a function of wavelength, showing that SH yield is lower than assumed in the models.

Fate-mapping and clonal analysis show that bronchioalveolar stem cells (BASCs) become activated and respond distinctly to different lung injuries and differentiate into multiple cell types. Single-cell RNA-seq analysis identifies new BASC markers.

Three-dimensional (3D) hydrogel printing enables production of volumetric architectures but achieving good resolutions for miniaturized features remains challenging. Here the authors demonstrate shrinking of a printed structure by immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge.

Chunsheng Wang and colleagues develop an electrolyte strategy to enable the use of commercially available microsized alloys, such as Si–Li, as high-performance battery anodes. They ascribe its success to the formation of robust LiF-rich layers as the solid–electrolyte interface.