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The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Acinetobacter baumannii is an opportunistic pathogen that causes nosocomial and community-acquired infections. Here, the authors determine that human neutrophil α-defensin HNP1 can promote A. baumannii biofilm formation.

Reducing platinum use is vital for sustainable hydrogen production via proton exchange membrane water electrolysis. Here, the authors report a Mo₂TiC₂ MXene-supported platinum nanocluster catalyst that requires minimal platinum content and operates efficiently for over 8700 h.

Here, the authors report the realization of room-temperature broadband mid-infrared detectors based on a van der Waals heterostructure with a vertical transport channel, exhibiting specific detectivity and response times comparable or superior to those of commercial cooled HgCdTe photodetectors.

Genetic studies of Chinese individuals have been performed, but mostly with short read sequencing, limiting the types of variants that can be identified. Here, the authors perform long read sequencing of 945 han Chinese individuals, finding structural variants under natural selection and those associated with human traits and evolutionary history.

Neuromorphic computing memristors are attractive to construct low-power- consumption electronic textiles. Here, authors report an ultralow-power textile memristor network of Ag/MoS2/HfAlOx/carbon nanotube with reconfigurable characteristics and firing energy consumption of 1.9 fJ/spike.

Migratory functionalization of C–H bonds through metal migration from carbon to carbon under transition metal catalysis is a process of significant academic and industrial interest. Here, the authors report a palladium-catalyzed migratory cyclization of α-bromoalkene derivatives to yield benzoheterocycles.

High-quality, non-layered 2D β-Bi₂O₃ crystals are grown using a vapour–liquid–solid–solid growth technique. These crystals demonstrate promising properties for p-channel field-effect transistors.

Efficient and stable catalysts for oxygen reduction reactions are difficult to achieve due to slow kinetics and degradation. Here, the authors use a ‘carbon defect anchoring’ strategy to create Pt₁Ni₁@Pt core-shell nanoparticles with high activity and durability.

Healthy and sustainable diets that better match the dietary preferences and economic affordability of specific groups are needed to achieve the Sustainable Development Goals. To address this gap, this study proposes a region-specific reference diet for China and compares it to global dietary guidelines.

The continued scaling of silicon based electronic devices requires the development of increasingly innovative approaches for high-precision material removal. Here, the authors demonstrate subnanometre depth removal of silicon using scanning probe, shear-induced mechanochemical reactions.

Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2α.

Brain-wide axonal projections of single neurons have been extensively reconstructed without any functional characterization. The authors present a method that allows for developing a precise one-to-one map of both projection patterns and functional features of single neurons in mice.

Creating flexible acoustoelectric devices with ultrathin thickness, high elasticity, stable conductivity, and high electromechanical energy conversion capability poses a challenge. Zhang et al. present a liquid crystal mediated technique that creates an elastic piezoelectric nanomembrane with double noise reduction, offering promise for auditory system reconstruction and other acoustoelectric conversion applications.

By performing a tissue-specific transcriptome analysis, Zhang et al. show how age-related loss of germline stem/progenitor cells in C. elegans is regulated by a signal produced by non-niche cells within the same organ system.

The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G₀–G₁ phase, thus suppressing proliferation in human hepatocellular carcinoma cells.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Biological ammonia-to-nitrite conversion (nitritation) in mainstream municipal wastewater is environmentally desirable but hard to stabilize. This study presents an effective loading rate switch strategy that enables stable nitritation in mainstream sewage.

Deciphering the sulfation and sialylation codes of ganglioside glycans is impeded by the limited accessibility of well-defined structures. Now, an integrated chemoenzymatic strategy has been developed for efficient synthesis of a comprehensive 65-membered ganglioside glycan library, enabling an extensive exploration into their structure–function relationships using glycan microarray technology.

Silicon has been incorporated into organic molecules in place of carbon under the principle that, given that they belong to the same periodic group, their reactivity could be similar. Here, the authors perform desymmetrizations on silacyclohexenone and the carbon analogue, with the two substrates yielding opposite enantiomers, showing that our understanding of the similarities of the two atoms is incomplete.

In support of an evolutionary model that links distaste, disgust and socio-moral processes, Gan et al. use functional magnetic resonance imaging to develop a neuromarker for subjective core disgust that generalizes to oral distaste and unfairness.

Phase change material for solar-thermal energy storage is widely studied to counter the mismatch between supply and demand in solar energy utilization. Here, authors introduce optical waveguide to regulate the solar-thermal conversion interface to enable the fast energy harvesting in solar-thermal energy storage system.

Cyclic-di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic-di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS via a cyclic-di-GMP-responsive T3SS chaperone.

Microwave devices are instrumental in wireless communications. Recently, spintronic-based microwave devices have seen significant interest, with the potential for smaller size, and lower power consumption. Here, Zhu et al demonstrate a spintronic amplifier with record gain, which uses material stacks already employed in industrially fabricated magnetic memories.

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

Operando recrystallization of ZnO NP films passivates defects and boosts electron mobility, enhancing radiative recombination and electron injection in QDs to achieve 33.7% EQE.

Swarms of microrobots could eventually be used to deliver drugs to specific targets in the body, but the coordination of these swarms in complex environments is challenging. Yang and colleagues present a real-time autonomous distribution planning method based on deep learning that controls both the shape and position of the swarm, as well as the imaging system used for swarm navigation to cover longer distances.

The authors examine the effects of antidiabetic medication on the gut microbiome and bile acid composition and show that these data can be used to stratify treatment regimens for type 2 diabetes.

H-NS is a global regulatory protein that represses expression of many genes in bacteria. Here, Li et al. show that a second messenger, cyclic di-GMP, binds to H-NS and inhibits its binding to DNA, thus relieving H-NS-mediated transcriptional silencing.

The gut microbiome affects systemic metabolism and is a therapeutic target for type 2 diabetes. Here the authors demonstrate in a randomized controlled trial that effects of berberine, a plant alkaloid known to lower blood glucose, may be explained by the inhibition of Ruminococcus bromii mediated biotransformation of the bile acid deoxycholic acid.