Search

Advanced membranes for industrial-scale water electrolysis hold promise yet pose challenges. Here, the authors report a two-step casting and phase separation strategy to design a composite membrane with differentially structured pores that combines ion transport and gas barrier functions.

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Lithium dendrite growth and liquid electrolyte volatilization limit the further development of lithium-oxygen batteries. Here, authors report a non-Newtonian fluid quasi-solid electrolyte to address those issues, which improve the life duration of the lithium-oxygen batteries.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Wu and colleagues show that T_H17 cells arising in the gut in response to segmented filamentous bacteria can convert to highly mobile follicular helper T_FH17 cells, emigrate to the spleen and regulate auto-antibody production and arthritis severity.

Based on an immunogenicity screen of monkeypox virus (MPXV) surface proteins, the authors develop an mRNA vaccine with 12 antigens, which they combine with T cell epitope-rich regions to achieve protection through coordinated activation of humoral and cellular immune responses.

Results of a multicentre phase 1 clinical trial evaluating treatment with the engineered herpes simplex virus VG161 in advanced liver cancer indicate a good safety profile and promising efficacy.

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

This study describes comprehensive dynamic divergence of subgenomes in allotetraploid cotton, with an focus on cis-regulatory elements and 3D genomic architecture at 12 major tissues/developmental stages throughout the life cycle.

High-quality assemblies of 15 diploid and 35 allotetraploid cotton accessions are analyzed in graph-based pan-genomes, providing insights into genome dynamics and regulatory control of fiber transcriptomes under varying ploidy and selection pressures.

The control of propagating light is a crucial aspect in photonics. Here Martins et al.demonstrate that by a careful design of their Fourier spectra, quasi-random nanostructures can achieve such control very efficiently.

It has been previously reported that the natural cytotoxic receptor NKp46 plays an important role in regulating natural killer (NK) cell biology. Here the authors show that NKp46 is required for the proliferation and cytotoxicity of type 1 innate lymphoid cells (ILCs) by activating the NF-κB signaling pathway and regulating IL-2Rα expression.

Acquired miR-142 deficit in leukemic stem cells has been associated with chronic myeloid leukemia blast crisis. Here the authors show that acquired miR-142 deficit in T cells further enables leukemic stem cells to escape immune surveillance and supports disease growth.

Accurate molecular representation of compounds is a fundamental challenge for drug discovery. Here, the authors present a molecular video-based foundation model pretrained on 120 million frames of 2 million molecular videos, and apply it to molecular targets and properties prediction.

Cholesteric liquid crystal elastomers (CLCEs) have tunable optical properties under an external field, but these properties revert once the field is removed. By introducing diselenide dynamic covalent bonds, the authors enable CLCEs to retain tunable optical properties after force and light exposure, achieving programmable, high resolution color patterning.

The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.

Pan-genome and pan-3D genome analyses of the Gossypium genus reveal evolutionary relationships among transposon-driven genome expansion and chromatin topology innovation and regulatory variations for cotton fiber development.

Here the authors develop an iterative particle sieving method called CryoSieve, demonstrating this method outperforms other cryo-EM particle sorting algorithms to reveal that most particles are unnecessary in final stacks.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

Development of high-performance, comfortable and sustainable air filters is challenging. Here, authors design an ultrathin, ultralight dual scale fiber mat composed of true nanofibers and submicron-fibers to integrate the high protection, thermal wet comfort and save raw materials.

Acral melanoma (AM) is a rare melanoma subtype with unique features, where lymph node metastasis is closely associated with clinical outcomes. Here, the authors use single-cell and spatial transcriptomics to analyse early dissemination, tumour microenvironment, and heterogeneity in AM, and infer metabolic shifts with therapeutic implications.

Genome and transcriptome analyses of 376 Gossypium hirsutum accessions uncover the regulation of gene expression during fiber development in allotetraploid cotton and highlight the potential for fiber quality improvement.

Severe COVID-19 requires immediate and targeted intervention that is efficient against SARS-CoV-2 and its variants. Authors show here the therapeutic potential of engineered natural killer cells that simultaneously express a chimeric antigen receptor targeting the spike protein of SARS-CoV-2, and IL-15, a cytokine that enhances the function and survival of their own.

Supramolecular polymeric materials have exhibited attractive features such as self-healing, reversibility and stimuli-responsiveness but because of the weak bonding nature of most noncovalent interactions, constructing supramolecular polymer materials with high robustness remains challenging. Here, the authors describe the construction of highly robust stimuli-responsive supramolecular polymer networks by using only a tiny amount of metallacycles as the supramolecular crosslinkers.

Yu and colleagues develop a OV-Cmab-CCL5 oncolytic virus that targets EGFR⁺ glioblastoma cells and releases CCL5 into the tumor microenvironment, which promotes anti-tumor immune responses and prolonged survival in preclinical GBM models.

A comparison of RNA-seq and microarray data from samples treated with diverse drugs highlights a dependency of cross-platform concordance on treatment effect.

Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.

Caligiuri and colleagues show that the m⁶A reader YTHDF2 modulates the inflammatory activation and antitumor function of tumor-associated macrophages in part by modulating the stability of Stat1 mRNA.

Two potent mitophagy inducers, identified and characterized via unsupervised machine learning and a cross-species screening approach, ameliorated the pathology of Alzheimer’s disease in worms and mice.

Presence of islet autoantibodies precedes the onset of type 1 diabetes but it does not predict whether and how fast symptomatic disease appears. Here authors present a model to predict and visualize progression to diabetes by using a large longitudinal data set on autoantibodies and clinical parameters as input.

Xianlong Zhang, Keith Lindsey and colleagues report a population genomic analysis of Upland cotton (Gossypium hirsutum) that identifies 93 potential domestication-sweep regions and 19 candidate loci for fiber-quality-related traits. Their analysis provides evidence for asymmetric subgenome selection for long white fibers in cultivated cotton.

This paper describes the use of paired Cas9 nickases to edit the mammalian genome with no detectable off-target effects.

Photocatalytic water splitting is a promising route to hydrogen generation from renewable solar power. Here, the authors report a hydrogen-evolving photochemical molecular device based on a self-assembled coordination cage, which simultaneously incorporates multiple photosensitizing and catalytic metal centres.

How ILC1s respond to cancer cells is somewhat controversial. Here, the authors show that IFNγ released by ILC1s can control acute myeloid leukemia by promoting leukemia stem cell apoptosis and favoring their differentiation into non-leukemic cells.

Knowledge of three-dimensional (3D) genome structure and how polyploidization shapes it remains poor. A study now characterizes and compares 3D genomes for diploid and tetraploid cotton, showing how allopolyploidization affects 3D genome architecture and transcriptional regulation.

The serine protease factor Xa (FXa) is upregulated in COVID-19 patients and functions in the coagulation pathway. Here, Dong et al characterise the basis of its antiviral activity in the context of SARS-CoV-2 pandemic variants.

Tropane alkaloids are medicinally significant plant metabolites generated by an unusual condensation of ornithine-derived and malonyl-CoA precursors. Here, Huang et al. show that pyrrolidine ketide synthase catalyzes a single round of condensation, which is followed by a non-enzymatic Mannich-like condensation.