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The hybridization thermodynamics of programmable DNA nanostructures forming metastable loop structures on RNA generate distinct electrical signals during translocation through solid-state nanopores, enabling the identification of single-base alterations.

Artatrovirenols A and B are two natural sesquiterpenoids with a complex tetracyclic backbone, and their chemical total synthesis is challenging. Here, the authors report a concise synthesis of artatrovirenols A and B in 9 and 8 steps, respectively, featuring a bioinspired [4 + 2] cycloaddition reaction to construct the tetracyclic core.

The reactivity of ketenes is limited to the conventional [2+n] mode where the ketene is used as a 2 C synthon. Here, the authors present a suite of reactivity of a vinylogous [4+n] cyclization mode of ketenes besides the conventional one, forming a variety of lactam type azacycles.

Single-cell sequencing reveals cellular heterogeneity but is challenged by technical noise and batch effects. Here, authors present CellFM, an 800-million-parameter foundation model trained on 100 million human cells through the MindSpore framework, which outperforms existing models in downstream tasks.

The quasi-two-dimensional antiferromagnet Co_1/3NbS₂ was recently reported to have a significant anomalous Hall effect. However, its controversial spin configuration has presented challenges in understanding the physical mechanism behind the AHE. Here, through an array of experimental probes, Gu, Peng and coauthors verify an intrinsic k-space Berry curvature as origin of the spontaneous Hall effect, and elucidate the ___domain-related magnetic reversal behaviours.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

Melting and squeezing pure metals between two sapphires covered in molybdenum disulfide produces diverse two-dimensional metals at the ångström thickness limit.

The δ-lactone 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one (EVP), synthesized by telomerization of CO₂ with 1,3-butadiene, is a promising monomer for the direct use of CO₂ in the synthesis of polymers, but its ring-opening polymerization (ROP) remains challenging. Here the authors report its chemoselective ROP using a phosphazene/urea binary catalyst, affording exclusively a linear unsaturated polyester which can be recycled back to the pristine monomer.

The feasibility and efficacy of neoadjuvant immunotherapy for resectable hepatocellular carcinoma (HCC) have been previously suggested. Here the authors report the results of a phase 1b trial of neoadjuvant tislelizumab plus stereotactic body radiotherapy and adjuvant tislelizumab in early-stage resectable HCC.

The complication of water adsorption on surfaces goes well beyond a simple hexagonal bilayer model predicted by the ice rule. Chen et al.observe an extended cyclical pattern of water tetramers on an insulator surface, which is attributable to the formation of periodic Bjerrum defects at high density.

Resolving the internal structure of water molecules adsorbed on solid surfaces is challenging. Submolecular-resolution imaging of individual water monomers and tetramers on NaCl(001) films supported by a Au(111) substrate is now reported. The molecular orbitals of adsorbed water were directly visualized, which lead to the discrimination between the orientation of the monomers and the tetramers H-bond directionality.

Cardiovascular diseases, underscore an urgent need for long-term cardiac monitoring and early detection of abnormalities. Here, the authors present a RF-based sensing system that monitors long-term heart rate variability with clinical-grade accuracy.

High-density single atom catalysts are crucial for improving catalytic performance but achieving metal contents above 10 wt% is challenging. Here, authors develop a negative pressure annealing strategy, which enables fabrication of catalysts with metal contents up to 27–45 wt% for 13 different metals.

Ruiqiang Li and colleagues report the whole-genome sequencing of a Tibetan female wild boar, as well as resequencing of 48 domestic pigs and wild boar from Tibet and China. Their analysis provides insights into the genetic diversity, population structure and evolution of the wild boar.

The genome of the scallop Patinopecten yessoensis is sequenced. This bivalve mollusc has a slow-evolving genome with features such as karyotype and Hox gene expression that may be close to that of the ancestral bilaterian.

Bivalve molluscs have evolved various characteristics to adapt to benthic filter-feeding. Here, Li et al investigate the genome, transcriptomes and proteomes of scallop Chlamys farreri, revealing evidences of molecular adaptations to semi-sessile life and neurotoxins.

The relationship between psoriasis and cancer remains unclear. Here, the authors use PheWAS, polygenic risk scores, and Mendelian randomization analyses to demonstrate that psoriasis is causally associated with lung and breast cancer.

It is difficult to control the geometric phase of particles as they undergo quantum tunnelling. Now tuning of the geometric phase of electron spin is demonstrated in tunnelling in a multilayer van der Waals antiferromagnet.

New van der Waals (vdW) dielectrics with high dielectric constants are required to enhance the performance of 2D electronic devices. Here, the authors report high-throughput first-principles calculations and a machine learning classifier to identify >50 promising vdW dielectrics suitable for 2D field-effect transistors.

The efficacy of drug-eluting stents remains limited due to delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here the authors propose a one-produces-multi stent coating, a drug-free strategy that supports in situ healing of vascular tissues, as demonstrated in rabbit and porcine models.

The development of n-type organic semiconductors (OSCs) has been held back due to stability issues. Here the authors report that vitamin C improves both the performance and stability of n-type OSCs and devices.

The biogeochemical roles of the plastisphere regulating N cycling are elusive. This study reveals the plastisphere as an emerging nitrifying niche, featured by distinct shifts in nitrifiers and potential substrate exchanges compared to seawater.

Age-related osteoporosis is known to be dependent on TGFβ1 signalling. Here the authors show that a subset of neutrophils (identified by TGFβ1⁺CCR5⁺) increase during aging in mouse bone marrow resulting in bone loss, while a CCR5 antagonist can reduce the neutrophil numbers and increase bone mass in aged mice.

Sulfur particles disperse in a functionalized reduced graphite oxide (rGO) cathode with a binder-less polymer electrolyte and a dual-anion ionic liquid-containing cross-linked PEO–LiFSI_0.1(Pyr₁₄TFSI)_0.4 are hot-pressed into an integrated electrode, serving as both the cathode and electrolyte. Dual-anion solid polymer electrolyte and rGO-functional integrated sulfur electrode presents a novel method to improve the electrochemical properties of lithium-sulfur batteries.

Despite the importance of osteoclast secretory lysosomes in bone digestion, the proteins that regulate them remain ill defined. Here, the authors identify Slc37a2 as a secretory lysosome sugar transporter that is required for maintenance of skeletal bone mass.

Cagβ is an ATPase in the H. pylori CagType4 secretion system essential for delivering the CagA effector to host cells. Here, authors present crystal structures of hexameric apo-Cagβ and Cagβ trapped in the monomeric state by its regulator CagZ, uncovering the regulatory mechanisms of Cagβ.

Nutrient sensing impinges on the autophagosome biogenesis. Here, the authors present evidence that plant energy sensing regulates the autophagosome closure by modulating the phosphorylation status and localization of the ESCRT machinery.

A three-phase system that is composed of a ferroelectric Na_0.5Bi_0.5TiO₃ matrix in which ferrimagnetic NiFe₂O₄ nanocolumns coated with antiferromagnetic p-type NiO are embedded exhibits self-biased magnetoelectric switching at room temperature.

Transposons are accepted as evolutionary catalysts but how they do so remains less clear. Analyzing 100 animal genomes finds that terminal inverted repeat-type transposable elements catalyze new gene structures and new genes in animals via both transposition-independent and -dependent mechanisms.

Ming Li, Ruiqiang Li and colleagues report the whole-genome sequencing of a male golden snub-nosed monkey, Rhinopithecus roxellana, as well as its relatives Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri. Their analysis provides insights into primate evolution and adaptation to a diet consisting primarily of leaves and seeds.

Sequencing and de novo assembly of seven wild relatives of soybean yields insights relevant to crop domestication and improvement.

Fluorination of organic molecules can dramatically change the properties and is commonly used for the synthesis of bioactive molecules. Here, the authors report the deoxyfluorination of alcohols and the selective monofluorination of diols using bench stable, tunable difluorocyclopropene reagents.

Generally, transition metal-catalyzed stereodivergent transfer semihydrogenation of alkynes realized regulation of stereoselectivity by a Z to E isomerization process. Here, authors report a Ni-catalyzed stereodivergent transfer semihydrogenation of alkynes with a base-assisted metal species modulation mechanism, delivering both olefinic isomers smoothly in orthogonal catalytic pathways using cheap and nontoxic catalysts and additives

Two-dimensional multiferroics with effective magnetoelectric coupling has not been realized. Here, the authors find a magnetoelectric coupling mechanism in two-dimensional CuCrP₂S₆ interlocked with heterogeneous ferrielectric state.