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The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

Frost is typically seen as a threat to plants and is expected to lead to decreased ecosystem carbon uptake due to reduced photosynthesis. However, this research shows that spring frosts can actually enhance ecosystem carbon absorption, while autumn frosts behave as expected, prompting an increase in carbon emissions.

The Zn-N₃ on Zn-N₃@SC-PC breaks 1:1 stoichiometric interaction rule with acid gases due to its protruded structure for more coordination between Zn vacant orbital and acid gases, thus exhibiting supra-multi-molar adsorption phenomena (SO₂/Zn-N₃ = 6:1).

Topological lasers often suffer from low directionality, and/or complex design requirements hindering operation at small wavelengths. Here, by using a few monolayers of perovskite quantum dots, the authors demonstrate a lithography-free, vertical-emitting, single-mode laser emitting in the green.

SAT1 is a rate-limiting enzyme in polyamine catabolism. Here, authors discover a non-canonical function of SAT1 regulating H3K27ac marks within genes required for mitosis regulation and chromosome segregation, enabling anchorage-independent cell survival and peritoneal metastasis of ovarian cancer cells.

The authors present a multiomics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits in Hispanic/Latino populations. They demonstrate how integrating GWAS with omics characterization can advance precision medicine.

Wang et al. reveal that epigenetic changes driven by zinc finger MYND-type containing 8 promote the transition from adenocarcinoma to antiandrogen-resistant neuroendocrine prostate cancer and offer a therapeutic approach by targeting the histone reader with a small molecule.

Translation and rotation are the two most fundamental forms of diffusion. Here, the authors provide evidence of the coupling between rotation and translation under confinement, and find that asymmetric rotations disrupt the order of molecular diffusion in zeolites, which can be applied to studies of selective separation.

The mitochondrial unfolded protein response is shown to inhibit pluripotency during somatic cell reprogramming and to inhibit the mesenchymal-to-epithelial transition through c-Jun-mediated histone acetylation.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Transcriptional dysregulation contributes to tumor progression. Here the authors show that transcriptional complex NELF interacts with SLUG, and co-opts KAT2B, to promote the expression of epithelial-mesenchymal transition (EMT) and stemness-associated genes in breast cancer.

Spontaneous liquid–liquid phase-separation behaviour of high-aspect-ratio fibrils, obtained from supramolecular polymerizations of synthetic components, forms tactoids by means of an entropy-driven pathway.

Ozone pollution is enhanced by increased non-combustion anthropogenic volatile organic compound emissions during heatwaves, according to atmospheric measurements and modelling of ozone concentrations in a heatwave in Shanghai.

Aberrant hypertranscription in cells can affect development and disease. Here, the authors show that DNA topoisomerase I prevents hypertranscription; not through its catalytic function, but through a DNA binding mechanism.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Functional analyses of the ABC-F protein YjjK (EttA) suggest that it acts as a sensor of cellular energy and controls entry into the translational elongation cycle. Using cryo-EM and single-molecule FRET, EttA is shown to bind the ribosomal E site and engage both the L1 stalk and P-site tRNA to restrain ribosomal dynamics.

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Flexible and fatigue-resistant optical fibers made from hydrogel allow optogenetic manipulations in the periphery in freely behaving mice.

Lattice shrinkage is a dominating factor for the strain-induced change of the electronic properties in vdW layered materials. Here, the authors discover a piezoresistivity in pressurized β′-In2Se3, which originates from the intralayer atomic motions.

In situ spatial transcriptomic analysis of more than 1 million cells are used to create a 200-nm-resolution spatial molecular atlas of the adult mouse central nervous system and identify previously unknown tissue architectures.

Influenza A infection results in γδ T cell influx and production of IL-17 in the lungs. Here, the authors show that this effect is primed by CD1-restricted ligands that are released by infected cells and presented by B1a cells in the lungs.

A multiancestry genome-wide association study of chronic alanine aminotransferase elevation identifies candidate risk loci for nonalcoholic fatty liver disease, with replication in external cohorts defined by histology or imaging.

The contributions that tRNA-ribosome interactions make to the dynamics of translocation are now assessed using single-molecule FRET analysis. The analysis indicates that the flexibility of tRNA plays a key role in tuning the dynamics of pre-translocation complex during translocation.

A population of neurons is identified in the lateral preoptic area that can drive the full range of social communication sounds with affective scaling during mating in mice.

Yongfeng Liu, Xianjin Xu, Junyuan Gao et al. perform in silico screening targeting compounds that resemble both KCNQ1 and PIP₂ structures and identify CP1 as a compound that could restore KCNQ1 currents after PIP₂ depletion. Like PIP₂, this compound can mediate VSD-pore coupling of the channel, albeit via a different mechanism from PIP₂.