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GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

SARS-CoV-2 evolves into new subtypes necessitating further vaccine development. Here the authors generate a trivalent vaccine with Receptor Binding Domains from Delta, BA.5 and XBB.1.5 variants and characterize immunogenicity and protection in mice and safety in a phase I vaccine trial in humans.

Acute Myeloid Leukaemia (AML) with Retinoic acid receptor-gamma (RARG) fusions have similarities to Acute Promyelocytic Leukemia (APL) but are not responsive to standard APL treatments. Here, the authors show the specific molecular mechanisms lead by RARG fusions in AML driving leukemogenesis and as potential therapeutic targets.

Accurately genotyping structural variations (SVs) from short-read sequencing data is challenging. Here, the authors introduce SVLearn for precise genotyping of bi-allelic SVs, demonstrating robust cross-species generalizability across multiple coverage levels.

In this work Qiu et al. demonstrate that the application of van der Waals technology to STM/STS will dramatically expand the capabilities of the latter, allowing STM/STS to investigate the structure, electronic properties and magnetism of 2D magnetic insulators at the atomic scale.

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Maternal polycystic ovary syndrome may impact the offspring’s long-term health. Here, the authors show that children of mothers with polycystic ovary syndrome have an increased risk of cardiovascular disease in childhood and young adulthood.

Peripherally derived regulatory T cells (pT_reg) exhibit immunosuppressive capacity. Here, the authors show that microRNA-31 acting through inhibiting its direct target Gprc5a negatively regulates pT_reggeneration and promotes the development of experimental autoimmune encephalomyelitis.

Copper catalysts are widely studied for electrochemical CO2 conversion, but their structural changes during reactions require further investigation. Here the authors propose that Cu undergoes transformation through alkali cation-induced cathodic corrosion when exposed to sufficiently negative potentials in the presence of alkali cations in the electrolyte.

The authors report Bose–Einstein condensation of a two-magnon bound state in Na₂BaNi(PO₄)₂. This should stimulate further work on these types of geometrically frustrated materials.

Lei et al. show that intranasal immunisation with their vaccine candidate is able to broadly protect mice from SARS-CoV-2 infection, including Omicron variants.

It is difficult to control the geometric phase of particles as they undergo quantum tunnelling. Now tuning of the geometric phase of electron spin is demonstrated in tunnelling in a multilayer van der Waals antiferromagnet.

The mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, the authors show that tumor cell-intrinsic ATP6V0A1 drives RABGEF1-dependent cholesterol absorption and thus triggers paracrine TGF-β1/SMAD3 signaling to inactive memory CD8⁺ T cells in CRC.

Genomic analysis of allo-tetraploid common carp and goldfish identifies parallel subgenome structure and divergent expression processes.

The metal monochalcogenides are a group of van der Waals layered semiconductors with ultra-high plasticity. It is now revealed that their plasticity is attributed to the ability to transform their stacking order or phases, coupled with the concurrent generation of a micro-crack network.

A chemical-vapour-deposition-based approach enables the phase-controllable synthesis of large-scale two-dimensional β-, β′- and α-In₂Se₃ films.

The effects of E45A or P38A capsid mutations on HIV core stability and infectivity are reversed by R132T or T216I. Here, authors used structural and biophysical methods to reveal short- and long-range rearrangements that explain stability changes.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient material bank, but single nucleus RNAseq using such tissues is challenging. Here the authors develop a droplet-based method called snRandom-seq for high-throughput and sensitive single nucleus RNA-seq of FFPE samples.

Many diseases can display distinct brain imaging phenotypes across individuals, potentially reflecting disease subtypes. However, biological interpretability is limited if the derived subtypes are not associated with genetic drivers or susceptibility factors. Here, the authors describe a deep-learning method that links imaging phenotypes with genetic factors, thereby conferring genetic correlations to the disease subtypes.

The role and mechanism of Srsf1 in GC-induced osteoblast apoptosis reveals that Srsf1 may serve as a target for treating GC-induced osteoporosis and osteonecrosis.

Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.

The design of open-shell nanographenes is commonly limited to systems featuring a single magnetic origin. Now a strategy that combines topological frustration and electron–electron interactions has been developed to generate a butterfly-shaped nanographene that hosts four highly entangled π-spins and exhibits both ferromagnetic and anti-ferromagnetic coupling.

Anlló et al. show that context effects on reward value encoding are found across 11 diverse countries, suggesting that this may be a basic feature of human decision-making.

Pseudo-Landau levels in strained graphene modify not only the local density of states, but also the transport through a Hall bar device.

Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.

Dry reforming of methane is an attractive route to convert greenhouse gases into valuable syngas. Here, the authors demonstrate design strategy to prepare efficient catalysts towards activation of both C–H and C = O bonds and provide atomic-level insights into interfacial synergistic catalysis.

We developed a technique to fabricate atomically precise quantum antidots with unprecedented robustness and tunable quantum hole states through self-assembled single vacancies in a two-dimensional transition metal dichalcogenide.

CDK4/6 inhibition is a promising therapeutic approach to treat cancer, but it is challenged by resistance development. Here, the authors show that the RNA binding protein LRPPRC forms a positive feedback loop with CDK6 and inhibiting LRPPRC with the FDA-approved gossypol acetate overcomes CDK4/6 inhibition resistance.

A versatile hydrothermal approach in an operando acidic environment created ferromagnetic single-atom spin catalysts (SASCs). Ni-based SASC exhibits a giant magnetic field enhancement of OER activity, boosting both water and saline water electrolysis.

A type I secretion effector, TesG, suppresses host immune response to promote chronic Pseudomonas aeruginosa infection.

Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.