Nature Search

Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase

Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

Tao-Tao Chen
Qiuhua Lu
Songying Ouyang
Research30 Jun 2025
Nature Chemical Biology

P: 1-11
Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.

Comparing to Gossypium hirsutum, G. barbadense cotton lines have superior fiber quality but lower fiber yield. Here, the authors construct pangenome using 12 newly assembled G. barbadense genomes and 17 publicly tetraploid cotton genomes and reveal yield- and fiber-related diversity and interspecific gene flow.

Qingying Meng
Peihao Xie
Daojun Yuan
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-18
Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Jiwei Shi
Gang Wang
Jiong Lu
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-12
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.

Zhe Li
Jiwei Zhang
Xianghuo He
ResearchOpen Access20 Apr 2018
Nature Communications

Volume: 9, P: 1-14
R-loop-dependent promoter-proximal termination ensures genome stability

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

Congling Xu
Chengyu Li
Fei Xavier Chen
ResearchOpen Access09 Aug 2023
Nature

Volume: 621, P: 610-619
Stabilization of layered lithium-rich manganese oxide for anion exchange membrane fuel cells and water electrolysers

The development of superior and cost-effective catalysts for the oxygen reduction and evolution reactions is pivotal for the future hydrogen economy. Now a series of Ru-modified Li₂MnO₃ catalysts have been designed to optimize the electronic structure and achieve a high performance in both oxygen reduction and evolution reactions, as demonstrated in practical anion exchange membrane fuel cell and water electrolyser tests.

Xuepeng Zhong
Lijun Sui
Jiwei Ma
Research12 Apr 2024
Nature Catalysis

Volume: 7, P: 546-559
Ultrahigh thermal stability and piezoelectricity of lead-free KNN-based texture piezoceramics

The authors induce a phase boundary similar to Pb(Zr, Ti)O₃’s morphotropic phase boundary structure in (K, Na)NbO₃-based ceramics, which exhibit high residual polarization as well as a significantly improved piezoelectric constant d₃₃.

Lihui Xu
Jinfeng Lin
Jiwei Zhai
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-11
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.

Xiao Gao
Qingwei Wang
Jianru Xiao
ResearchOpen Access06 Aug 2020
Nature Communications

Volume: 11, P: 1-10
Scalable and hierarchically designed polymer film as a selective thermal emitter for high-performance all-day radiative cooling

A hierarchically designed polymer nanofibre-based film produced by a scalable electrospinning process enables selective mid-infrared emission and effective sunlight reflection, and thus realizes an excellent all-day radiative cooling performance.

Duo Li
Xin Liu
Jia Zhu
Research16 Nov 2020
Nature Nanotechnology

Volume: 16, P: 153-158
Widespread sea surface salinification induced by tropical cyclones over the Changjiang River Plume

Tropical cyclones can significantly reduce the extent of the Changjiang River plume and induce surface salinification, with Tropical Cyclone Lekima in 2019 causing up to 6.5 psu salinification and an 83% contraction of the plume, according to a combination of satellite and in-situ observations and modelling experiments.

Shoude Guan
Mengya Huang
Jiwei Tian
ResearchOpen Access02 May 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Fatigue failure of prefabricated crack HTPB(hydroxyl-terminated polybutadiene) propellant under strain control

Genfeng Li
Bo Gao
Jian He
ResearchOpen Access14 Feb 2025
Scientific Reports

Volume: 15, P: 1-14
Synthesis and structures of gold and copper carbene intermediates in catalytic amination of alkynes

Metal carbenes are typically highly reactive and unstable species, proposed as intermediates in numerous catalytic processes. Here the authors report the isolation and characterization of gold and copper carbene intermediates involved in catalytic cyclization reactions.

Jiwei Wang
Xiaoming Cao
Jun Zhang
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-10
Inhibition of hypoxic exosomal miR-423-3p decreases glioma progression by restricting autophagy in astrocytes

Ziyi Tang
Zhiwei Xue
Xingang Li
ResearchOpen Access08 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-15
Geminal-atom catalysis for cross-coupling

Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.

Xiao Hai
Yang Zheng
Jiong Lu
Research20 Sept 2023
Nature

Volume: 622, P: 754-760
Generating active metal/oxide reverse interfaces through coordinated migration of single atoms

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This ___domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

Lina Zhang
Shaolong Wan
Haifeng Xiong
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Contribution of boundary non-stoichiometry to the lower-temperature plasticity in high-pressure sintered boron carbide

Improving plasticity in non-oxide ceramics while maintaining their high-temperature strength is challenging. Here, the authors report an enhancement of plasticity in B₄C owing to the boundary non-stoichiometry. The results show excellent strength maintenance before the onset of plasticity.

Haiyue Xu
Wei Ji
Zhengyi Fu
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p

Zehua Bian
Jiwei Zhang
Zhaohui Huang
ResearchOpen Access28 Nov 2017
Oncogenesis

Volume: 6, P: 1-11
Promoting water dissociation for efficient solar driven CO₂ electroreduction via improving hydroxyl adsorption

Exploring efficient electrocatalysts with fundamental understanding of the reaction mechanism is important for CO₂ electroreduction. Here, the authors report a strategy of promoting water dissociation to achieve high solar to chemical conversion and identify key surface species for the reaction.

Xin Chen
Junxiang Chen
Lequan Liu
ResearchOpen Access10 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

Caicun Zhou
Ziping Wang
Jason Yang
Research15 Jun 2023
Nature Cancer

Volume: 4, P: 860-871
THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma

Jiwei Cheng
Haibo Ma
Wenqun Xing
ResearchOpen Access14 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-16
Publisher Correction: Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

Caicun Zhou
Ziping Wang
Jason Yang
Amendments and Corrections05 Jan 2024
Nature Cancer

Volume: 5, P: 209
Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma

Liangsong Zhu
Yilun Hong
Jin Zhang
ResearchOpen Access19 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-9
Wafer-scale two-dimensional ferromagnetic Fe₃GeTe₂ thin films grown by molecular beam epitaxy

Shanshan Liu
Xiang Yuan
Faxian Xiu
ResearchOpen Access14 Sept 2017
npj 2D Materials and Applications

Volume: 1, P: 1-7
Observed and simulated submesoscale vertical pump of an anticyclonic eddy in the South China Sea

Yisen Zhong
Annalisa Bracco
Zhiwei Zhang
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Jialun Li
Lu Lu
Jiemin Wong
ResearchOpen Access15 Aug 2023
Cell Discovery

Volume: 9, P: 1-17
LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p

Zehua Bian
Liugen Jin
Zhaohui Huang
ResearchOpen Access05 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
Hexavalent chromium elimination from wastewater by integrated micro-electrolysis composites synthesized from red mud and rice straw via a facile one-pot method

Huabin Wang
Ting Cui
Yong Zhang
ResearchOpen Access20 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Lingxia Liu
Xiliu Zhang
Jun Lu
Research29 Apr 2021
Oncogene

Volume: 40, P: 3548-3563
Notch1 promotes resistance to cisplatin by up-regulating Ecto-5′-nucleotidase (CD73) in triple-negative breast cancer cells

Yuzhu Qi
Meifang Li
Guo-jun Zhang
ResearchOpen Access30 Jun 2023
Cell Death Discovery

Volume: 9, P: 1-9
Chemolithotrophic biosynthesis of organic carbon associated with volcanic ash in the Mariana Trough, Pacific Ocean

Volcanic ash alteration supports chemolithotrophic activity at the seabed and contributes to the production of microbial biomass during diagenesis, suggest analyses of isoprenoid and branched glycerol dialkyl glycerol tetraethers distributions in Mariana Trough tuffs and adjacent sediments.

Taisi Li
Jiwei Li
Xiaotong Peng
ResearchOpen Access17 Mar 2023
Communications Earth & Environment

Volume: 4, P: 1-10
Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancer

An extensive analysis of public bulk and single-cell data in colorectal cancer (CRC) patients extends immune classifications in CRC and uncovers more detail in the tumor microenvironment.

Si Li
Tao Pan
Yongsheng Li
ResearchOpen Access27 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Lepidopteran wing scales contain abundant cross-linked film-forming histidine-rich cuticular proteins

Liu et al. analyse the protein composition of developing wing scales in the domestic silk moth. This molecular study of scales provides fundamental information about how such a fine microstructure is constructed and insights into the potential application of His-rich cuticular proteins as new biomaterials.

Jianqiu Liu
Zhiwei Chen
Kazuei Mita
ResearchOpen Access22 Apr 2021
Communications Biology

Volume: 4, P: 1-10
Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis

Xiaoya Duan
Yuanyong Huang
Jiemin Wong
ResearchOpen Access04 May 2021
Oncogenesis

Volume: 10, P: 1-15
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner

Mengru Xie
Qingming Tang
Lili Chen
ResearchOpen Access30 Sept 2020
International Journal of Oral Science

Volume: 12, P: 1-9
Arithmetic Skill May Refine the Performance of Individuals with High Math Anxiety, Especially in the Calculation Task: An ERP Study

Bijuan Huang
Xiaomeng Zhao
Jiwei Si
ResearchOpen Access16 Sept 2019
Scientific Reports

Volume: 9, P: 1-11

Search

Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase

Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.

Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

R-loop-dependent promoter-proximal termination ensures genome stability

Stabilization of layered lithium-rich manganese oxide for anion exchange membrane fuel cells and water electrolysers

Ultrahigh thermal stability and piezoelectricity of lead-free KNN-based texture piezoceramics

The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

Scalable and hierarchically designed polymer film as a selective thermal emitter for high-performance all-day radiative cooling

Widespread sea surface salinification induced by tropical cyclones over the Changjiang River Plume

Fatigue failure of prefabricated crack HTPB(hydroxyl-terminated polybutadiene) propellant under strain control

Synthesis and structures of gold and copper carbene intermediates in catalytic amination of alkynes

Inhibition of hypoxic exosomal miR-423-3p decreases glioma progression by restricting autophagy in astrocytes

Geminal-atom catalysis for cross-coupling

Generating active metal/oxide reverse interfaces through coordinated migration of single atoms

Contribution of boundary non-stoichiometry to the lower-temperature plasticity in high-pressure sintered boron carbide

Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p

Promoting water dissociation for efficient solar driven CO₂ electroreduction via improving hydroxyl adsorption

Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma

Publisher Correction: Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma

Wafer-scale two-dimensional ferromagnetic Fe₃GeTe₂ thin films grown by molecular beam epitaxy

Observed and simulated submesoscale vertical pump of an anticyclonic eddy in the South China Sea

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p

Hexavalent chromium elimination from wastewater by integrated micro-electrolysis composites synthesized from red mud and rice straw via a facile one-pot method

Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Notch1 promotes resistance to cisplatin by up-regulating Ecto-5′-nucleotidase (CD73) in triple-negative breast cancer cells

Chemolithotrophic biosynthesis of organic carbon associated with volcanic ash in the Mariana Trough, Pacific Ocean

Deep immunophenotyping reveals clinically distinct cellular states and ecosystems in large-scale colorectal cancer

Lepidopteran wing scales contain abundant cross-linked film-forming histidine-rich cuticular proteins

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis

Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner

Arithmetic Skill May Refine the Performance of Individuals with High Math Anxiety, Especially in the Calculation Task: An ERP Study

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