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This study demonstrates stable photoelectricity-induced halide segregation in epitaxial mixed-halide perovskite microwire networks on mica, verified by in-situ observations. Dynamic segregation-recovery processes and reconfigurable self-powered photoresponse reveal physical computing potential.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

Silicon electrodes promise high energy for lithium-ion batteries but face swelling and durability issues. Here, the authors develop a sieving-pore design that enables stable, fast-charging silicon electrodes with long cycle life, low expansion, and industrial-scale potential.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Single-atom catalysts (SACs) are potent tools for Fenton catalysis. However, current SACs face limitations due to the specificity of their supports. Here, the authors synthesised CoSAs-ZnO, that can selectively generate sulfate radicals and singlet oxygen in peroxymonosulfate and peracetic acid systems, respectively.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Closed pores govern sodium-ion storage performance of hard carbon negative electrodes. Here, authors link pore mouth size evolution of the closed pores to the solvation structure and propose design principles for optimizing both closed pores and intrinsic defects.

Efficient and stable heterogeneous catalysts for sustained oxidant activation are vital for solving the global water crisis but elusive. Here, the authors explore the in situ dynamic reconstruction of graphitic carbon nitride photocatalysts with iodine redox mediators, to develop a solar-driven Fenton-like system that activates periodate for effective and sustainable wastewater regeneration.

Use of N-methoxyamides as oxidants enables controllable, redox-neutral, green catalysis of bimodal dehydrogenation/lactonization reactions with methanol as the only by-product.

SACs are known for their Fenton-like catalytic performance but face a trade-off between activity and stability in PMS -based systems. Here, authors address this issue by developing a nano-island encapsulated Co SAC that enhances the activity and stability of PMS activation via an “island-sea” effect.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Optically reconfigurable elements are in demand for future applications. The authors report on the use of chirality-invertible cholesteric liquid crystals to actively manipulate geometric phase and create switchable planar optics elements that perform a variety of functions.

Shen et al. report a method for multiplexing isogenic iPSCs for single-cell RNA-seq. With it, they created an atlas of in vitro differentiation and identified TMEM88 as a regulator of cardiovascular development, impacting blood pressure in adult mice.

The limited solubility, inherent chemical stability, and low reactivity of inorganic phosphates pose hinder their conversion into organophosphates under mild conditions. Here, the authors report a method for the direct conversion of phosphates into P(V)-X reagents via a redox-neutral halogenation process, using cyanuric chloride or cyanuric fluoride as the halogenation reagent.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

Acyl radicals represent a reactive species that allow for aldehyde subunits to be nucleophilic instead of their typical electrophilic behavior; however, these species are difficult to access in mild conditions. Here the authors show a method to generate acyl radicals using only an organic photocatalyst and light, and these species are shown as competent nucleophiles in a variety of couplings.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Catalyst deactivation commonly occurs in heterogeneous catalytic advanced oxidation processes, but the mechanisms are not well understood. This study finds that catalyst deactivation is closely related to deposition of polymeric products of the pollutant-removal process.

Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors identify two independent associations within the MHC region and one new susceptibility locus on chromosome 6q27, which contains the genes RNASET2, FGFR1OP and CCR6.

Dietary inulin fibre alters the composition and metabolism of gut microbiota, resulting in elevated levels of bile acids that subsequently trigger mucosal type 2 inflammation characterized by eosinophilia, with clinical implications for allergy and anti-helminth defence.

This study revealed an NF-YB1-SLRL2-bHLH144 regulatory module, centered on a key transcription factor SLRL2, that mediates the ABA-regulated amylose content in rice. Furthermore, SLRL2 is also involved in the regulation of rice dormancy

Xue-Jun Zhang, Jun Wang and colleagues identify mutations in MVK in disseminated superficial actinic porokeratosis, a disorder characterized by defects in epidermal keratinization. MVK encodes mevalonate kinase, an enzyme involved in the biosynthesis of cholesterol and isoprenoids.

Demand-side mitigation solutions are seen as an essential part for climate actions, yet their adoption is still lower than expected. Cost–benefit analysis shows that the main barriers lie in the non-pecuniary costs of behaviour switching, and highlights opportunities for targeted policy intervention.

IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk.

Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Here, using datasets from the gut microbiome of 996 patients from seven clinical trials, the authors characterize gut microbial genomic structural variants, located in species such as Akkermansia muciniphila, Dorea formicigenerans, and Bacteroides caccae, that associate with hosts’ response and survival after immune checkpoint inhibitors treatment.

Reduced-dimensional halide perovskites are promising for light-emitting diodes but suffer from photo-degradation. Here Quan et al. identify the edge of the perovskite nanoplatelets as the degradation channels and use phosphine oxides to passivate the edges and boost device performance and lifetime.

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Artificial photocatalytic systems based on graphitic carbon nitride are improving, but production of high-value products at electron and hole sites is challenging. Here, the authors report a system using graphite-phase carbon nitride modified with potassium iodide/triiodide eutectic salt to generate H₂O₂ and benzaldehyde.

Global warming is expected to increase mortality due to heat stress in many regions. Here, the authors asses how mortality due to high temperatures changes in China changes for different demographic groups and show that heat-related excess mortality is increasing under climate change, a process that is strongly amplified by population ageing.

Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.

While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser. Here, the authors address this by using the catTFRE approach to profile active TFs in 24 adult and 8 fetal mouse tissues, and presenting the TF networks in major mouse organs.

Type 1 conventional dendritic cells (cDC1) play a pivotal role in the cross-presentation of antigens, enabling efficient CD8 + T cell response. Here authors show that the transcription factor Zeb1 essentially regulates this process via facilitating the reactive-oxygen-species-dependent rupture of phagosomal membrane to allow antigen export to the cytoplasm.

Cryptophytes are ancestral photosynthetic organisms. Here the authors report the cryo-EM structure of the PSII–ACPII from the cryptophyte Chroomonas placoidea, showing that cryptophyte PSII–ACPII consists of a PSII dimer and twelve ACPII monomers that are organised into four linear trimers.

Rice grain shape or size is an important trait associated with both yield and appearance quality. Here, the authors identify GS9 as a negative transcription regulator of slender grain and show it can improve grain shape and appearance independently from other previously identified grain size genes.

Using a ligand as a promoter enhances the reactivity of the palladium catalyst in non-directed C–H functionalization of arenes, enabling the arene to be used as the limiting reagent.