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Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Gain-of-function mutations in CTNNB1 (encoding for b-catenin) leading to deregulated Wnt/β-catenin signaling are frequently observed in patients with hepatocellular carcinoma (HCC). Here the authors show that inhibiting b-catenin with lipid nanoparticles encapsulating siRNA targeting CTNNB1 impairs tumor growth and promotes anti-tumor immunity in preclinical HCC models.

Gold redox catalysis is an attractive synthetic method but challenging due to the high redox potential of Au(I)/Au(III). Now, a bidentate N-ligand-assisted gold redox catalysis using H₂O₂ as oxidant has been developed. It can be applied to various coupling reactions, including C(sp)–C(sp) cross-coupling, alkynylative cyclization and bicyclization coupling.

Wheat stem rust resistance gene Sr6-mediated resistance is enhanced at lower temperatures whereas Sr13 and Sr21 resistances are enhanced at higher temperatures. Here, the authors clone Sr6 and show the divergent molecular pathways governing temperature-dependent resistance among these genes.

OmiCLIP is a visual–omics foundation model that integrates histology and spatial transcriptomics. The associated Loki platform offers accurate and robust tools for alignment, annotation, cell-type decomposition and spatial gene expression prediction.

Riboflavin is an essential vitamin for humans. Here, authors present cryo-EM structures of human riboflavin transporter RFVT2/RFVT3, revealing the structural basis for riboflavin transport and defining the determinant for pH-dependent activity of RFVT3.

Here Tai et al. unveil elevated formation of the C-terminal binding protein (CtBP)–tripartite-motif-containing protein 28 (TRIM28) complex in breast cancer cells and mutual protection between CtBP and TRIM28. This complex is required for mammary gland development and its high levels lead to breast cancer metastasis by repressing autophagy.

Organic batteries are promising for sustainable energy storage but face challenges in performance and cost. Here, authors develop pressurized organic electrodes with high capacity and durability under practical and extreme conditions, advancing organic batteries toward real-world applications.

A size-sieved complex precipitation in Sc-added Al–Mg alloys achieves a high-density dispersion of both fine Al₃Sc nanoprecipitates and in situ formed core-shell Al₃(Mg, Sc)₂/Al₃Sc nanophases with high hydrogen-trapping ability.

A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

Synthetic antiferromagnets, where two ferromagnetic layers are antiferromagnetically coupled offer a variety of advantages for spintronic applications. Here, Ma, Liu, and coauthors demonstrate optical control of both the RKKY interaction and the perpendicular magnetic anisotropy in a synthetic antiferromagnet.

Determining the size of critical nuclei remains challenging. Here the authors propose a method to determine the size of critical secondary nuclei on growth faces of poly(butylene succinate) single crystals in solution, using the probability of statistically selecting crystallizable units in random copolymers.

Flowcell type and basecaller configuration of nanopore sequencing are crucial for data analysis but are often missing in public datasets, hindering large-scale integrative analysis. Here, the authors present LongBow, which restores this information from FASTQ files.

Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. Herein, the authors present a simple approach to assembling such intriguing skeletons from tryptamine-derived isocyanides through a cascade sequence, which includes an oxidative trifluorination and a subsequent halogenative cyclization.

Acute myeloid leukaemia(AML) modifies the bone marrow(BM) microenvironment, impacting hematopoiesis. Here, the authors demonstrate that AML-modified BM endothelial progenitor cells(EPC) remodelling supports normal hematopoiesis after complete remission and this process is improved by the antioxidant N-acetyl-L-cysteine(NAC).

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

Determining the causal variants at GWAS loci is crucial for understanding genetic disease mechanisms. Here, the authors apply MPRA to perform non-small cell lung cancer (NSCLC) variant-to-function mapping at scale and propose distinct genetic architectures underlying NSCLC susceptibility.

Ectoparasites activate prefrontal microglia via the skin–brain axis, damaging GABAergic neurons and reducing host exploration. This limits host distribution and may help ectoparasites avoid environmental pressures.

Reversed forks must be protected from uncontrolled nucleolytic degradation. Xie et al. reveal a collaborative defense mechanism orchestrated by Myb/SANT-like DNA-binding ___domain-containing protein 4 and the breast cancer susceptibility proteins (BRCA1/2)–DNA repair protein RAD51 pathway, which synergistically preserve the integrity of reversed forks.

SMAD ubiquitylation regulatory factor 1 (Smurf1) was identified as a critical activator of the phosphoinositide 3-kinase (PI3K)–Akt pathway by promoting phosphoinositide-dependent protein kinase 1 (PDK1) neddylation and cytoplasmic complex of PDK1 assembled with Smurf1 and SETDB1 (cCOMPASS) assembly. Smurf1-antagonizing repressor of tumor 1 (SMART1), a highly selective degrader for Smurf1, was developed and suppressed the tumor growth of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutant colorectal cancer.

The reason of mature tertiary lymphoid structures (mTLS) correlates with better prognosis and responses to immune checkpoint blockade (ICB) remains incompletely understood. By employing sequencing and spatial transcriptomics strategies, the authors show that mTLS are enriched with progenitor exhausted CD4⁺ T cells that promotes activation of T and B cells.

A plant kinase mediates symbiotic signalling and suppress host immunity to enable legume–rhizobium symbiosis.

Chai et al. use cryo-electron microscopy to systematically interrogate the conformational landscape of motor protein dynein. The reported structures reveal intermediate states in the mechanochemical cycle of dynein, the role of adenosine triphosphate and the communication mechanism with microtubules.

Friction and wear cause widespread energy loss and damage. Here, the authors propose a strategy to reduce friction and wear through inducing dynamic electronic density redistribution via alternating electric current.

The photochemical transformations of aryl thiols to other functional groups have been scarcely explored. Here the authors present a carboxylation of aryl thiols using 1 atmosphere of CO₂ under photoirradiative conditions, a methodology which can be extended to the degradation of polyphenylene sulfide.

Crystalline dispersoids are commonly used to strengthen metals by obstructing dislocation movement, but this often comes at the cost of ductility. Here, the authors demonstrate that amorphous nanoparticles, introduced via additive manufacturing, enhance both the tensile strength and fatigue resistance of metallic materials.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

This study discovers primitive mantle olivines in the Chang’e-6 lunar soils from the Moon’s far side, shedding new light on the Moon’s origin and evolutionary processes.

Feske and colleagues show how STIM- and ORAI-dependent calcium activation of NFAT plus IFN–STAT1 signaling activates T-bet expression independently of IL-12 stimulation. This NFAT–STAT1 activation pathway is required for T_H1 cell differentiation and protection against viral infections when IL-12 is missing.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.