Search

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

There is a need to design soft robots for rapid movement in extreme environments, though it is a challenge to balance electronic and mechanical properties while being stable in extreme conditions. Here the authors design an ethylene glycol gel which balances stability with its electronic and mechanical performance.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Wang, Wang, Pan and colleagues uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, phase separation and stimulates downstream innate immune signalling.

Microsatellite-instability-high gastric cancers typically respond to immune checkpoint inhibitors, but only a small proportion of patients in the microsatellite-stable group responds. Here authors stratify these patients via a semi-supervised learning approach using multi-omics input data and functionally validate T-bet+ CD8 + T cells as crucial factor in the immunotherapy response.

Sensing of cytosolic RNA or DNA can lead to innate responses, but little information is available for RNA/DNA dual sensors. Here the authors find SAMD9 as a potential dual sensor linked to pro-inflammatory responses, interferon induction and resistance to viral infection, as evidenced by in vitro overexpression and in vivo knockout mouse data.

The exact mechanism for superconductivity in iron-based superconductors remains elusive, but is thought to involve complex interactions between many orbitals. Using angle-resolved photoelectron spectroscopy, Liuet al. report the electronic structure of the single-layer parent compound FeSe.

Solid-phase extraction combined with charged aerosol detection is demonstrated to allow quantification of organosulphates in ambient aerosols without reliance on authentic standards.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

Li et al. report the sublattice decoupling in Rb₆Re₆S₈I₈ upon compression, in which [Rb₆I₂]⁴⁺ framework can be selectively amorphized while the [Re₆S₈I₆]^4- clusters keep in ordered state, leading to emission-to-photocurrent switching at 15 GPa, which can retain when back to ambient condition.

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.

The coexistence of topological and superconducting states in a single layer of FeSe on a SrTiO₃ substrate is reported.

The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.

Here, particulate matter metrics are assessed and associated with sand and dust storm health risks. The oxidative potential and the environmentally persistent free radicals of particulate matter could be used to develop effective sand and dust risk prevention in dust-prone countries.

Inducers of ferroptosis hold potential for cancer therapy. Here, the authors identify a peroxide-decorated liposome capable of inducing ferroptosis and enhancing the efficacy of chemotherapeutic agents and radiotherapy.

Hydrogen-bonded organic frameworks (HOFs) attract increasing attention as porous materials. Despite the widely studied solid-state properties, little research has been done on the solution state. Here, the authors demonstrate that HOFs fragment into small particles while maintaining their original assemblies upon dispersing in solvents.

Reversing the thermal induced sintering phenomenon and forming high temperature stable fine dispersed metallic centers is one of the ever-lasting targets in heterogeneous catalysis. Here the authors report the dispersion of metallic Ni particles into under-coordinated two-dimensional Ni clusters over γ-Mo₂N.

Wearable thermocells are limited by poor durability and thermal inefficiencies. Here, the authors develop a high-strength, fatigue-resistant thermocell with enhanced thermoelectric performance. By enhancing crystal domains and entropy difference, it boosts fatigue resistance and thermopower.

The authors achieve a multicomponent out-of-plane-ordered MAX phase (o-MAX) by stoichiometrically mixing two existing o-MAXs, which inherits the chemical ordering from the originating phases and has adjustable properties, demonstrating a promising strategy for o-MAX construction.

Su, Zhao, Jiang and colleagues identify IGFBP6 as an intrinsic downregulator of the inflammatory response lost in disturbed flow-induced atherosclerotic plaque development, suggesting that its restoration may represent a viable therapeutic strategy.

Emerging in-memory computing using memristors promises better energy efficiency but often focuses on existing AI algorithms. Here, the authors report a distinct and computation-efficient AI algorithm based on memristor drift-diffusion kinetics for pattern classification, implemented on 180 nm memristor chips.

The coupling of acetonitrile into succinonitrile via a dehydrogenative route is highly attractive in terms of valuable chemical synthesis and green hydrogen energy production. Here, the authors report succinonitrile synthesis with high selectivity and rate via a light driven dehydrogenative coupling reaction of CH₃CN over the anatase TiO₂ supported Pt catalyst.

The unique band structure of topological insulators gives rise to insulating bulk and unusual metallic surface properties. By tuning the content of Sb in the ternary compound (Bi_1–xSb_x)₂Te₃, Wang and collaborators show it is possible to control the precise features of the band structure in a continuous fashion.

Nanocarriers are promising in tumour-targeting drug delivery but limited by their delivery efficiency within tumour microenvironment (TME). Here the authors report the development of lipoic acid boronophenylalanine derivatives linked by short-chain PEG spacers which can self-assemble into versatile vesicles under TME-specific pH for targeted cancer therapy.

Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding ___domain (RBD) proteins, the authors identify a number of single ___domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

An ytterbium sublattice in an erbium-sensitized multilayer core–shell structure enables photon upconversion from lanthanide ions under 1,530 nm irradiation.

Here, the authors characterize the utilization of 20 medicinal polysaccharides by 28 human gut Bacteroides and Parabacteroides species, revealing substantial variability in bacterial growth responses, which they link to genomic differences in carbohydrate-active enzymes.

A thermophoretic aptasensor can be used to profile cancer-associated proteins of extracellular vesicles (EVs) in patients’ plasma. Here, the authors use this technique to develop an EV-signature able to discriminate metastatic breast cancer, monitor treatment response, and predict patients’ progression-free survival.

Asymmetric hydrogenation (AH) and direct reductive amination (DRA) are both frequently utilized in chemical industry. Here, the authors combine these two transformations to efficiently convert in one step prochiral olefins into chiral amino compounds.

Synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells provide substantial enhancements in the expansion and potency of engineered human cytotoxic T cells.

Stereodivergent construction of adjacent quaternary-quaternary stereocenters remains a formidable synthetic challenge. Here, the authors report a nickel-catalyzed enantioselective dearomatization Claisen rearrangement leading to vicinal all-carbon stereocentres and apply it to the stereodivergent synthesis of bioactive hyperolactones.

Podocytes are susceptible to injury and undergo a series of adaptive, maladaptive or catastrophic responses depending on the severity and duration of the insult. Emerging evidence indicates a central role for Wnt/β-catenin signalling in mediating podocyte dysfunction and the development of proteinuria. Here, Lili Zhou and Youhua Liu describe advances in current understanding of the pathomechanisms of Wnt/β-catenin signalling in mediating podocyte injury and discuss the therapeutic potential of targeting this pathway for the treatment of proteinuric kidney disease.

Achieving high-performance conjugated polymers with intrinsic flexibility and printable capacity is a great challenge. Here, the authors report asymmetric substituted polymers with strong inter aggregate capillary interaction for deep-blue flexible printed polymer light-emitting diodes.

Heterostructures of indium gallium zinc oxide and tungsten diselenide can be used to create phototransistor arrays capable of three-dimensional morphology reconstruction, two-dimensional depth field mapping and multi-view coupling.

Unlocking the complexities of protein structures and interactions within subcellular organelles is challenging. Here, the authors introduce SPACX, a method for spatially resolved protein complex profiling using biocompatible chemical cross-linking, enabling the analysis of protein conformation, interactions, and translocation in living cells.