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He et al. report spin-LEDs based on chiral perovskite quantum dots which act as localized spin-selective units and radiative recombination centers simultaneously. Ultrasonic treatment assisted ligand exchange enables spin-LEDs with peak efficiency of 16.8% and dissymmetry factor of 0.285.

Predictive electrocatalyst design is challenged by uncontrollable precatalyst reconstruction during operation. Here, informed by operando spectroscopies, activation protocols are developed to stabilize surfaces and improve catalyst reliability.

Chen et al. present a deep learning-based lead optimization model that combines generative artificial intelligence with structure-based approaches. The method is successfully applied to the design of drug-like molecules targeting the recently identified LTK protein target with high potency and selectivity.

A unified framework is presented that integrates observed spatial patterns of individual trees in forests with ecological processes into a novel coexistence theory.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

UDA-seq incorporates a post-indexing step to enhance the throughput of droplet-based single-cell multimodal sequencing, enabling efficient large-scale single-cell analysis.

Accurate short-term wind speed prediction is crucial for wind power systems. Authors propose a machine learning-based short-term wind prediction network using CNN-Transformer architecture, demonstrating strong transferability and robustness for predicting wind speeds in various climatic regions.

Forest productivity stability should increase with succession. However, examining forest inventory dataset from the eastern United States, the authors find that productivity stability decreased with stand age and recommend protecting species diversity at multiple scales.

The authors demonstrate voltage-controlled multiferroic magnon torque in BiFeO₃ heterostructures, enabling reconfigurable logic-in-memory devices. This work highlights potential for low-power, scalable magnonics in room-temperature computing.

Arterial vascular grafts are promising for vascular reconstruction but face risk of restenosis. Here, the authors report an electronic vascular conduit for in situ, long-term monitoring of thrombosis concurrent with postoperative vascular repair in in small animals and nonhuman primates.

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. Here, the authors show that SGK1 drives hippocampal demyelination and DACD via regulating NDRG1 phosphorylation.

Coordinating protein translation with energy supply is a significant challenge faced by cells. Here, the authors found that the protein quality control network may provide a link between the two.

Graphene has great potential in various electronic devices, but obtaining large-area suspended graphene is problematic. Here, the authors use carbon nanotubes as supports for graphene, enabling large areas of strong and 90% electron transparent suspended graphene to be realized.

Two epigenetic regulators—identified in an RNA interference screen in Caenhorhabditis elegans, and conserved in mammals—diminish mitochondrial function and accelerate the age-related deterioration of behaviour.

A yttrium-doped metallic two-dimensional buffer layer can be used to improve charge carrier transport between the metal contacts and semiconductor channel in molybdenum-disulfide-based transistors.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Textbook theory asserts that dislocation hardening inherently sacrifices ductility. Here, the authors report that high-density dislocations with segregation-modified configurations produced by additive manufacturing increase strength without compromising ductility.

The complexity of matching ABO blood groups presents a formidable barrier to successful transplantation. Here, the authors show that an enzymatic converted type B kidney was transplanted into a type O brain-dead recipient without hyperacute rejection.

The instability of lipid nanoparticles during nebulization hinders inhaled mRNA vaccines. Here, the authors report on a charge-assisted stabilization strategy using a peptide-lipid conjugate to improve lipid nanoparticle stability, enabling mRNA-based mucosal vaccines for SARS-CoV-2 and lung cancer.

The heterodimer of METTL1-WDR4 is responsible for adding methylation group to the N7 atom of guanine (m7G) in tRNA molecules. Here the authors show how the tRNA m7G modification mediates tRNA stability to control proteostasis by maintaining efficient protein synthesis, which is important for preventing premature senescence and aging.

The role of coagulation system in erythropoiesis is not clear. Here, the authors report that an anticoagulant protein TFPI from erythroblasts directs central macrophages to synthesize heme, which in turn promotes erythropoiesis in bone marrow.

In this study, multiple μ-spatially offset Raman spectroscopy is used to determine blood glucose levels noninvasively in humans, achieving comparatively high accuracy in a clinical setting.

Here the authors developed a multi-phenotype imputation method termed PIXANT by leveraging efficient machine learning (ML)-based algorithms.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

In Mendelian randomization, correlated pleiotropy can lead to false positives. Here, the authors introduce a clustering model that detects correlated pleiotropy, allowing accurate causal inference in situations with high correlated pleiotropy.

Immunotherapy in prostate cancer conventionally leads to a low response rate and inadequate therapeutic efficacy. Here, the authors address these issues by developing a nanozyme-based system with sonosensitive and magnetic-targeting capabilities to mitigate the immunosuppressive tumor microenvironment and enhance the body’s immune response, achieving sono-metallo-immunotherapy for prostate cancer.

The authors obtain the TiCoSb-based single-crystals with a dimension exceeding 1 cm, leading to an extraordinary enhancement in electron mobility and consequently, an average power factor of 37 W cm⁻¹ K⁻² in the Nb-doped TiCoSb single-crystal.

This study presents a neuromorphic computing platform capable of learning cross-modal, event-driven signals for efficient real-time knowledge generalization. It also achieves zero-shot transfer learning for multimodal data.

Ionizable lipid optimization is essential for mRNA therapy via lipid nanoparticle, but experimental screening is investment-intensive. Here, authors developed AI models achieving the rational design of lipid molecules and fast high-throughput screening.

Ming-Rong Wang, Benjamin Berman and colleagues perform whole-exome sequencing and global methylation profiling on different tumor regions of esophageal squamous cell carcinoma. They find evidence for intratumoral heterogeneity and identify late driver mutations targeting oncogenes and early driver mutations occurring in tumor-suppressor genes.

In this study, the authors report a potent neutralizing antibody targeting a conserved epitope within RSV pre-F that shows higher antiviral activity against both RSV-A and -B subgroups in vitro and in small animal models than FDA-approved prophylactic agents.