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Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

The authors report a dual photothermal-electrocatalysis interface which enables efficient ammonia extraction and purification from air and wastewater, thereby advancing sustainable waste-to-fuel conversion.

The authors demonstrate resonant excitation of phonon-polaritons based on THz-driven ZnO single crystals. This clarifies the generation mechanism of phonon-polaritons, enabling their observation for various nonlinear regimes.

Diffuse intrinsic pontine glioma (DIPG) is driven by H3K27M oncohistones, but the exact related mechanisms are poorly understood. Here, the authors identify an H3.3K27M oncohistone-driven CREB5/ID1 axis that promotes transcriptional changes and progression in DIPG, which could represent a potential therapeutic target.

In this work, authors design novel protein condensation inhibitors (PCIs) targeting an allosteric site of cGAS, blocking DNA interactions and phase separation to suppress immune activation, and demonstrate therapeutic potential in inflammatory disease models.

A utility-based assessment shows that the global installation of photovoltaic plants to harness solar energy between 2000 and 2018 led to an increase in terrestrial ecosystem carbon pools of 2.1 TgC.

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Penketh et al. develop an approach for mapping the frequency response of thousands of meta-atoms in a microwave metasurface simultaneously, leading to the formation of detailed hyperspectral images. The approach – applicable to a wide range of metasurfaces – may overcome fabrication challenges for translation of such metasurfaces to real-world devices.

Using a global database of the radiocarbon content of rivers combining new and published measurements, isotopic mass balance suggests that about 60% of river CO₂ emissions are derived from millennial or older carbon sources.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

The utility of photosensitizers for cancer therapies is often hindered by a single photosensitizing mechanism, the need of multiple irradiations, and limited tumor penetration and retention. Here, the authors address these issues by developing an aggregation-induced emission luminogen bacteria hybrid bionic robot that enables multimodal imaging and therapy and activates anti-tumor immunity.

Collisionless shock waves at relativistic velocities are ubiquitous in the universe and lead to the generation of energetic ions and radiation. Here, the authors demonstrate the generation of subrelativistic collisionless shock of astrophysical relevance in the laboratory, by means of table-top femtosecond laser pulses focused onto solid targets.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Single-layer NbSe₂ has a charge density wave with two degenerate domains, related by mirror reflection. Here, using scanning tunneling microscopy, the authors observe the time-dependent movement of ___domain walls, and demonstrate reversible switching between the two ___domain types using a voltage pulse from the microscope tip.

Interorgan communications play key roles in the regulation of whole-body energy metabolism. Here, the authors report the myokine Musclin as a negative regulator of beige adipose thermogenesis and systemic energy homeostasis through Tfr1/PKA signalling mediated muscle fat crosstalk.

Spin-split bands and certain lattice symmetries are required to generate the spin currents needed for spintronics applications. Now a layered room-temperature antiferromagnet is shown to exhibit anisotropic spin splitting between valleys paired by a crystal symmetry.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

The photooxidation of CH₄ to CH₃OH is limited by the availability of reactants at flooded interfaces. Now the authors report a modified metal organic framework nanoreactor to promote the direct photooxidation of CH4 to CH₃OH at the gas-solid interface.

Climate warming causes riverine CO₂ emissions increasing at 0.42 ± 0.16 Tg C yr⁻¹ in the Northern Hemisphere permafrost regions during 2000–2020.

Despite the lower device efficiency, tin perovskite based solar cells are preferred choices compared to lead-based counterparts due to much lower toxicity. Here Jiang et al. use a fullerene derivative to greatly suppress carrier interface recombination and obtain record high cell efficiency of 12%.

Reducing circuit redundancy represents a priority for the scalability of parallel computing hardware. Here, the authors report the realization of pixel processing units consisting of single 2D WSe₂ transistors implementing electrically-switchable logic functions. This strategy enables the fabrication of an image processing array with ~16% transistor consumption compared to traditional circuits.

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

Using a polymer stamp with a period arrangement of micro-posts on its surface and a high surface tension liquid, two-dimensional material films can be patterned and transferred on a large-scale with high yield.

An efficient approach is developed to enforce spin symmetry for neural network wavefunctions when solving the many-body Schrödinger equation. This enables accurate and spin-pure simulations of both ground and excited states.

Low-dose electron microscopy has revealed nonclassical beam damage mechanisms and their descriptive models by enabling real-space visualization of radiation-induced structural dynamics in a metal-organic framework.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

The relationship between Mott state and charge density wave state in two dimensional materials remains unclear. Here, Liu et al. reveal spatial distribution of a Mott-Hubbard band in monolayer 1T-NbSe₂ forming a new periodic pattern in addition to the well-known CDW pattern.

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Molecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.

The commercialization of light-emitting diodes based on emissive quantum dots (e.g. QLEDs) is hindered by their inherent poor operational lifetime. Using an intelligent energy-level design strategy, Qian et al. demonstrate QLEDs with operational lifetime that meets industrial display standards.

The populous global land monsoon region has been suffering from extreme precipitation. Here, the authors show that limiting global warming to 1.5 °C instead of 2 °C could reduce areal and population exposures to baseline once-in-20-year rainfall extremes by 25% (18–41%) and 36% (22–46%), respectively.

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

The authors highlight the role of acyl coenzyme A binding protein (encoded by DBI) in Cushing’s syndrome by using six different inhibition methods and mapping the physiological effects.

Powdery mildew disease seriously threatens wheat production by reducing grain yield and quality. Here, the authors clone the Znf-BED-bearing NLR protein encoding powdery mildew resistance gene Pm6Sl derived from wild wheat species Aegilops longissima and show its application in breeding resistance cultivars.