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Remote C–H bond formation via photoenzymatic hydrogen atom transfer has enabled the precise installation of remote stereocentres but is still in its infancy. Here, the authors report the photoenzymatic stereoablative enantioconvergence of γ-chiral oximes using repurposed flavin-dependent ene-reductases.

A product-oriented strategy that leverages the reactivities of different functional groups in real-life plastic mixtures can be used to obtain valuable products, opening a path for managing end-of-life plastic mixtures.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.

Gas-evolving catalysts suffer from severe mass transport limitations under industrial conditions. Here, the authors report an interfacial metal-layer engineering strategy to separate bubble nucleation from active sites, enabling transfer-resistance-free electrocatalytic interfaces.

Here, the authors fabricate hybrid van der Waals heterostructures based on 2D tessellations of DNA origami thin films, graphene and boron nitride, showing that the DNA films can induce periodic superlattices at the interface and modulate the electronic properties of the samples.

The GEMS satellite’s hourly measurements enhance the accuracy of surface O₃ estimation, leading to lower O₃ concentrations and a reduction in O₃-related deaths, particularly in rural regions, revealing overestimated mortality in previous assessments.

The amination of C(sp3)–H bonds is an appealing and challenging task in organic synthesis. Here, by using an electrogenerated sulfate radical an HAT agent, the authors report a practical Ritter-type amination of C(sp3)–H bonds.

Biodegradation of polyesters such as polylactic acid (PLA), which could serve as a carbon source for value-added chemicals, leads to CO₂ emissions. Here the authors develop a two-step catalytic process to convert PLA into methyl methacrylate, a key building-block molecule, for sustainable valorization of waste PLA.

TMPRSS2 and CTSL/CTSB, host proteases that facilitate SARS-CoV-2 entry, are promising drug targets. Here the authors simultaneously inhibit these host proteases and see synergistic antiviral effects, offering a broad-spectrum intervention against SARS-CoV-2 variants.

Myeloid-derived suppressor cells play an important role in immune suppression caused by Echinococcus multilocularis infection. This study demonstrates that the removal of this cell type effectively restores T-cell function and potentiates PD-1 blockade therapy in chronic liver infection.

Paclitaxel, a first line chemotherapeutic drug, suffers from poor water solubility and low tissue selectivity. Here, the authors report a water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profiles.

Few-layer semiconducting Cr₂Ge₂Te₆ shows bipolar gate-tuned magnetism below its ferromagnetic Curie temperature.

A high-density genomic variation map from 744 genomes encompassing maize and all wild taxa of the genus Zea reveals evidence of adaptive variation and provides a genus-wide resource of genetic diversity in Zea.

Cryo-ET and subtomogram averaging analyses are used to determine structures of HIV-1 Env trimers on the surface of inactivated virions.

Layered thio- and seleno-phosphate ferroelectrics show promise for next-generation memory but have thermal stability issues. Using the electric field-driven phase transition in antiferroelectric CuCrP2S6, the authors introduce a robust memristor, emphasizing the potential of van der Waals antiferroelectrics in advanced neuromorphic computing.

Northern China contains some of the world’s earliest farming societies. Here, authors use 55 ancient genomes to trace the genetic history of human migrations across northern China for the last 7500 years, and document genetic changes mirroring shifts in subsistence strategy.

The inherent rigidity of the azaarene ring structure has made it challenging to achieve remote stereocontrol through asymmetric catalysis on these substrates. Now, through a photoenzymatic process, an ene-reductase system facilitates the production of diverse azaarenes with distant γ-stereocentres, highlighting the potential of biocatalysts for stereoselectivity at remote sites.

A benchmarking competition improves tools that predict how regulatory regions control gene expression.

Controlled growth of heterostructures within 10 nm scale is crucial for potential applications of transition metal dichalcogenides. Here, the authors report strain-driven synthesis of ultra-long MoS₂ nano-channels having several micrometers length and 2–30 nm width embedded within MoSe₂ monolayer.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

Fluorescent RNA aptamers could potentially be used as protein-independent reporters of transgene expression in plants. Here, the authors report that an optimized RNA aptamer, developed from Broccoli, can be used to detect transgene expression in stable and transiently transformed plant tissue.

Low thermal conduction and conformability of traditional rigid heat sinks limit their adoption in flexible electronics and soft robotics. Here, authors report a liquid metal skeleton-based active-cooling elastomer with high thermal conductivity, stretchability, and hydraulic-driven adaptable morphing.

Reversing the thermal induced sintering phenomenon and forming high temperature stable fine dispersed metallic centers is one of the ever-lasting targets in heterogeneous catalysis. Here the authors report the dispersion of metallic Ni particles into under-coordinated two-dimensional Ni clusters over γ-Mo₂N.

Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.

Single-site catalysts supported by ultrathin two-dimensional (2D) porous matrix are desirable for catalytic reactions, yet their synthesis remains a great challenge. Herein the authors report a cocoon silk chemistry strategy to synthesize isolated metal single-site catalysts embedded in ultrathin 2D porous N-doped carbon nanosheets.

Here, the authors exploit a photo-induced barrier-lowering mechanism in MoS₂/ α-MoO_3-x heterojunctions to realize two-dimensional phototransistors with enhanced performance and fast response at low bias voltage.

Single-molecule fluorescence resonance energy transfer imaging of conformational states of HIV-1 envelope glycoprotein trimers on intact virus and of trimers used in previous structural studies reveal the latter as downstream—rather than pre-triggered—conformations.