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Natural products populate areas of chemical space not occupied by average synthetic molecules. Here, an analysis of more than 180,000 natural product structures results in a library of 2,000 natural-product-derived fragments, which resemble the properties of the natural products themselves and give access to novel inhibitor chemotypes.

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

This study shows that brain connectivity changes in Huntington’s disease begin decades before symptoms, shifting from hyper- to hypoconnectivity, with links to specific neurotransmitter systems specially in granular and infragranular cortical layers.

Atomic-scale simulations and microscopy experiments reveal copper surfaces restructure during CO₂ electroreduction, driven by CO adsorption, forming active sites adjacent to defects that are crucial for catalyst activity and product selectivity.

Integration of color centers in wide-band semiconductors with electronic and photonic devices is required for their applications in quantum technologies. Here the authors report electronic, optical and spin control of a single vacancy center in a 4H-SiC Schottky diode integrated with optical microstructures.

Encasing a single atom within a fullerene (C₆₀) cage can create a robustly packaged single atomic spin system. Here, the authors perform electron paramagnetic resonance on a single encased spin using a diamond NV-center, demonstrating the first steps in controlling single spins in fullerene cages.

The authors present a theoretical treatment demonstrating that NMR experiments on chiral molecules can reveal enantioselective nuclear J-couplings due to bond polarization and spin-orbit interaction. This also aids in understanding chirality-induced phenomena more generally and their applications.

The spindle assembly checkpoint protects cells from chromosome missegregation. Here, the authors use sophisticated biochemical reconstitutions to address how kinetochores, the microtubule-binding structures of chromosomes, regulate this checkpoint.

Sodium-ion batteries face challenges due to electrode degradation and interphase instability. Here, authors develop a smart gel polymer electrolyte for hard carbon||NaNi_1/3Fe_1/3Mn_1/3O₂ batteries via in situ polymerization of specific monomers in conventional electrolytes.

This Perspective highlights the important role of energy metabolism in psychiatric disorders and sets the groundwork for future studies in the emerging field of metabolic psychiatry.

Detecting the magnetic spins of a small number of atoms is important for applications such as magnetic resonance imaging. Here, Steinert et al.demonstrate that nitrogen-vacancy defect centres in diamond allow spin detection at room temperature at length scales smaller than human cells.

Recently, there has been significant effort in combining spin qubits in silicon with an optical interface for increased efficiency and scalability. Here the authors demonstrate the optical initialization, coherent control, and single-shot readout of a single erbium spin in a nanophotonic silicon resonator.

Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interactions and the role of cofactors.

Ion implantation is used to introduce spin defects in solids, but it inflicts residual lattice damage, degrading performances. Here the authors demonstrate that the charge state of induced defects influences such damage, and that charging vacancies leads to improved coherence times and yield of centres.

X-ray spectroscopy offers element-selective probes of diverse (bio)chemical systems. Close coupling of experiment with ab initio calculations unveils the rich electronic structural information available and facilitates practical, chemical interpretation of spectra, as discussed in this Review.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Using cryo-EM, SAXS and HDX–MS, the authors mechanistically delineate dimerization-induced autoinhibition of the HECT-type ligase HACE1 and the selectivity of the active ligase monomer for GTP-bound RAC1.

Clock transitions, typically observed in arrays of trapped atoms, can now be observed for electron spins in silicon doped with bismuth.

By extracting non-Gaussian cosmological information on galaxy clustering at nonlinear scales, a framework for cosmic inference (SimBIG) provides more precise constraints for testing cosmological models.

The human cortex displays an anterior-to-posterior asymmetry, identified via both post-mortem and in vivo microstructural measurements. Microstructural asymmetry is heritable, varies across cortical layers and between sexes, and relates to functional asymmetry and behavior.

Here, the authors demonstrate that cortical microstructure in young adults shows marked sex bias, which is most pronounced in paralimbic areas. The effects are put into context with variations in sex hormones and local cytoarchitecture.

This study shows atomic-scale observations of geometric reconstruction in a fluorine-intercalated infinite layer nickelate superlattice, highlighting how fluorine influences the material’s structure and electronic properties.

External driving of Rabi oscillations is a first step in the coherent manipulation of spin systems. Here the authors use ultrafast optical pulses to produce classical Rabi oscillations in ferromagnetic CoFeB, enabling the exploration of coherent phenomena in dense ferromagnetic ensembles.

Pompe disease (PD) is a rare disorder that leads to progressive muscle weakness if left untreated. Here, the authors use multispectral optoacoustic tomography (MSOT) to map and quantify the composition of affected muscle tissue to determine disease severity and potentially monitor future therapies.

Coherent transfer of an optical photon polarization state to a single nuclear spin in a nitrogen–vacancy defect centre in diamond is demonstrated without a high-finesse cavity. A storage time of 10 s is achieved with a transfer fidelity of 98%.

Here the authors combine a multimodal imaging-snRNAseq transcriptomics strategy to provide insight into the distribution of a neurotropic tick-borne flavivirus in the brain, and show that absence of interferon signaling increases infection of resident microglia.

Adolescence is a period of considerable brain remodelling. Here the authors demonstrate that behavioural adaptation to adverse environmental influences links to the microstructural and functional maturation of the adolescent brain.

Cyclopalladation of a covalent organic framework based on azobenzene allows the extension of light absorption into the near-infrared region. The framework is catalytically active for the photoreduction of oxygen to hydrogen peroxide under 810 nm irradiation.

The organization of electrolytes at the air/water interface affects the structure of interfacial water and therefore numerous natural processes. It has now been demonstrated that the surface of an electrolyte solution is stratified and consists of an ion-depleted outer surface and an ion-enriched subsurface layer, jointly determining the water interfacial structure.

Observations of teraelectronvolt-energy γ-rays starting about one minute after the γ-ray burst GRB 190114C reveal a distinct component of the afterglow emission with power comparable to the synchrotron emission.

The authors show the RNA-induced droplet formation by a component of Cajal bodies and reveal the large nanoseconds mobility of glycine residues inside droplets as a molecular factor potentially contributing to the large dynamics of Cajal bodies.

It is generally assumed that CO₂ production is coupled to ferredoxin reduction during anaerobic alkane oxidation in archaea. Here, Lemaire et al. use biochemical and structural techniques to study native enzymes purified from an ethane-oxidising enrichment culture, showing that the enzymes deliver electrons to the F₄₂₀ cofactor rather than to ferredoxin.

Diract imaging of supercurrent flow at a Josephson junction has been inaccessible in experiment. Here, using nanoscale magnetometry, the authors find large kinetic inductance of thin film superconductors can lead to competing Josephson vortex states hidden below the critical current, and also provide a new route towards the Josephson diode effect.

Nitrogen-vacancy centers in diamond offer a promising platform for quantum applications but their optical and spin properties can be hampered by imperfections of the host crystal. Here, nitrogen-vacancy centers are created in high-pressure high-temperature diamond of high crystalline quality, demonstrating a small inhomogeneous broadening of the spin and optical transitions.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.