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Lithium-rich cathode materials face challenges due to the irreversibility of redox processes at high voltages, limiting their practical use. However, their significant potential is evident in applications like low-speed e-mobility, and their integration into solid-state electrolytes could pave the way for wider adoption in the future.

The retention of galactose-deficient IgA1 (Gd-IgA1) in the mesangium leads to pathogenesis in IgA nephropathy. Here the authors report that Gd-IgA1 is internalized by mesangial cells potentially via transferrin receptor 1, forming aggregates that disrupt lysosomal function and elicit inflammation.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

The precise control and transition between multiple stochiometric phases is challenging. Here, the authors grow and characterize four wafer-scale stoichiometric phases of a Pd-Te binary compound through a sequential multi-step nucleation process.

Lithium-ion batteries suffer from complicated degradation behaviours, posing challenges for recycling. This Review explores the failure mechanisms in state-of-the-art cathode materials from the particle to the cell scale and discusses how these insights can help to improve material extraction and direct regeneration to optimize recycling processes.

CRISPR-TO, a system for programmable control of spatial localization of cellular RNAs, is presented and enables functional investigation of endogenous RNA localization in diverse living cells.

The transition between yeast and hyphae is crucial for the pathogenicity of Candida albicans. Here, Liu et al. show that vacuole fusion is active during hyphal extension and that large vacuoles increase the mechanical forces of hyphae penetrating into organs.

Chen et al. present a deep learning-based lead optimization model that combines generative artificial intelligence with structure-based approaches. The method is successfully applied to the design of drug-like molecules targeting the recently identified LTK protein target with high potency and selectivity.

Rosacea is a common chronic inflammatory skin disorder mainly affecting the central face. Here, a single-cell atlas of facial skin from rosacea patients and healthy individuals reveals the molecular and cellular changes in skin-resident cell populations and identifies fibroblasts as a determinant in rosacea development.

Constructing organic fluorophosphines via direct fluorination of alkyl phosphonates is challenging. Herein, the authors show that alkyl phosphonates are electrophilically activated with triflic anhydride and N-heteroaromatic bases, enabling nucleophilic fluorination at room temperature to form fluorophosphines via reactive phosphine intermediates.

Mechanisms and consequences of the acclimation of soil respiration to warming are unclear. Here, the authors combine soil respiration, metagenomics, and functional gene results from a 7-year grassland warming experiment to a microbial-enzyme decomposition model, showing functional gene information to lower uncertainty and improve fit.

A Ca–O₂ battery that relies on a highly reversible two-electron redox to form chemically reactive calcium peroxide as the discharge product is reported to be stable in air and rechargeable for 700 cycles at room temperature.

Rosacea is a common, multi-factorial chronic inflammatory skin disorder. Here authors provide evidence of genetic predisposition by whole genome sequencing and whole exome sequencing of samples from familial cases, and by recapitulating a recurrent mutation in the LRRC4 gene in a mouse model, they find that neuron-derived vasoactive intestinal peptide is an important pathogenic factor for neurogenic inflammation in rosacea.’

The authors investigate the response of Archaea to experimental warming in a tallgrass prairie ecosystem. Warming was linked to reduced diversity and convergent succession, with further links to changed ecosystem function. Stochastic processes dominated community changes but decreased over time.

Understanding plant–microbe–soil interactions enables the design of effective solutions for agriculture under suboptimal conditions. This study reports the identification of aluminium-resistant bacteria and their potential contribution to increased rice yields in acidic soils.

Non-precious metals used at the anode of anion-exchange-membrane fuel cells to catalyse hydrogen oxidation are prone to self-oxidation. Here Zhou and colleagues report that a quantum well-like catalytic structure containing Ni nanoparticles within a C-doped MoO_x/MoO_x heterojunction can mitigate such degradation by a gating operation.

Luminescent materials with narrowband emissions are vital for optoelectronic applications. Here, the authors achieve room temperature phosphorescence with a FWHM of 30 nm through the multiple resonance effect and showcase its practical application in X-ray imaging.

Here, the authors target intratumoral T_reg cells to enhance antitumor immunity without affecting systemic T_reg cell function and identify JMJD1C as a critical epigenetic regulator of tumor T_reg cell fitness.

Phosphoantigen-mediated BTN2A1 association drives BTN3A1 intracellular fluctuations outwards in a thermodynamically favourable manner, thereby enabling BTN3A1 to push off from the BTN2A1 ectodomain to initiate T cell receptor–mediated γδ T cell activation.

Tang et al. utilized proximity labelling to assemble the Arabidopsis nuclear pore-associated proteome and revealed the nuclear pore as an integrated platform coupling multiple steps in gene expression regulation, beyond its conventional transport role.

Moro et al. discover an Argonaute 2 (Ago2)-dependent miRNA network that, in response to substrate stiffness, regulates genes involved in tissue mechanics, and show that Ago2 restrains stiffness and contributes to regeneration in the zebrafish fin fold.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

End capping of oligonucleotides is crucial for enhancing their stability and therapeutic efficacy by resisting 3’ exonuclease degradation, yet the underlying mechanisms remain elusive. Here, the authors design an epimer of threose nucleic acid by replacing deoxyribose with an α-D-erythrofuranosyl moiety, demonstrating its superior stability and resistance by affecting the binding positions of terminal nucleotides in the phosphodiesterase active site.

ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Delivering the correct concentration of drugs to the correct ___location is a challenge in cancer therapy. Here, the authors generate a drug loaded nanoparticle that enlarges following contact with the internal tumour cell environment, resulting in the retention of the nanoparticle and loaded drugs in cancer cells.

The formation of the pre-metastatic niche enables the colonisation of disseminated cancer cells in distant organs. Here, the authors show that Th2 cytokines induce Complement 3 production in lung mesenchymal stromal cells, which recruits neutrophils and promotes the formation neutrophil extracellular traps, facilitating breast cancer cell metastasis to the lungs.

Xu Tan, Yong Yang and colleagues identify patients with epidermolysis bullosa harboring mutations in KLHL24, which encodes a cullin 3–RBX1 ubiquitin ligase substrate receptor. They find that truncating mutations stabilize the protein by abolishing autoubiquitination, leading to enhanced ubiquitination and degradation of KRT14, the target substrate of KLHL24.

Nitrate electroreduction to ammonia can decrease pollutants and produce high-value ammonia. Here, the authors design a Fe/Cu diatomic catalyst on nitrogen-doped graphene, which exhibits high catalytic activities of and selectivity for ammonia.

Primary tumors “spread the spark” by establishing a pre-metastatic niche. Here the authors develop an in-situ assembled peptide FR17 to serve as a “flame-retarding blanket” to extinguish the “fire” of the pre-metastatic microenvironment.

A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV-2 variants, combined with small molecule drugs for an enhanced antiviral effect in human primary cells.

Ancestral avian influenza A viruses are used to identify adaptive changes in viral polymerase and nucleoproteins that enable efficient replication and transmission in pigs.

Lower- and middle-income countries are disproportionately impacted by the reduction of winter cereals yields and fragmentation of the food trade due to the Russia-Ukraine war, according to an analysis that uses satellite cropland data, meteorological and trade data, and network approach.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Using a multifactorial global change experiment, the authors show that warming grassland plots by +3 °C over 6 years accelerates the scaling rate of both taxonomic and phylogenetic diversity in soil bacterial and fungal communities.