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In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

The 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme complex regulating the TCA cycle. Here, the authors use cryo-EM and cryo-ET to discern native structures of the whole complex and reveal its assembly mechanism.

The preparation of high quality crystalline covalent organic framework (COF) films without polymer contamination and controllable thickness is desirable for optoelectronic applications. Here, the authors report a diffusion-limited synthesis strategy for wafer-scale COF films with a controlled structure, thickness, patterning, and crystallization degree based on the adjustment of the precursor building block films.

LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle changes in LC-MS status in large-scale quantitative proteomics experiments. They further prioritized 15 QC metrics and developed an AI model, implemented in a free software called iDIA-QC, for detecting LC-MS faults.

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

The distinction of liver lesions is critical for the accurate diagnosis and treatment of liver cancer. Here, the authors develop LiLNet, a deep learning-based system to identify focal liver lesions as well as benign and malignant liver tumours from CT images with high accuracy across multiple patient cohorts.

Sanguinarine is a plant-derived benzylisoquinoline alkaloid that exhibits diverse pharmacological activities. Here, the authors report the complete biosynthesis of sanguinarine and halogenated derivatives using engineered yeast strains through a temperature-responsive dynamic control strategy.

Hyperbolic metamaterials exhibit interesting optical phenomena that could provide useful functionalities, if the losses can be reduced. Here Caldwell et al.show that hexagonal boron nitride supports hyperbolic polaritons, presenting a natural alternative to metamaterial systems.

In a cluster-randomized trial performed in 48 residential elderly care facilities in China, use of a low-sodium salt substitute instead of regular salt decreased blood pressure and cardiovascular events, whereas an alternative strategy of restricting salt consumption was not successful and did not have these beneficial effects.

Using a mixture of 4-fluorophenethylamine and 4-trifluoromethyl-phenylammonium to create a tailored 2D perovskite layer reduces the inhomogeneity at the top interface of all-perovskite tandem cells and results in the highest efficiency reported so far.

The authors study transport in the superconducting state of infinite-layer nickelate Nd_0.8Sr_0.2NiO₂ films using a Corbino-disk configuration, finding that the magnetoresistance changes from isotropic to four-fold anisotropic with increasing magnetic field. At even higher field, an additional two-fold component emerges, which coincides with an anomalous upturn of the critical field.

The direct synthesis of light aromatics, particularly para-xylene (p-X), from syngas/CO₂ is gaining considerable attention, though enhancing the space-time yield (STY) of p-X remains a significant challenge. Here, the authors develop a dynamic ‘dual-engine-driven’ catalytic system that achieves a remarkably higher p-X STY by integrating ZnCr and FeMn with Z5@SiO₂ capsule zeolite.

The role of cations in the CO₂ electroreduction is crucial, but elusive. Here, the authors combine electrokinetic on a well-defined single-atom catalyst with grand canonical potential kinetics simulations to provide an in-depth study of the interaction of K ⁺ -ions with adsorbed CO₂⁻.

Authors uncover room-temperature skyrmions in 2D van der Waals material, attributing their presence to Fe-deficiency-induced symmetry breaking, enabling topological Hall effect and small Néel-type skyrmions with femtosecond laser writability.

This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.

Huanming Yang, Zhiming Cai, Jun Wang and colleagues report whole-exome sequencing of 10 clear cell renal cell carcinomas followed by a screen of ~1,100 genes in a total of 98 tumors. They found 12 new disease-associated genes and detected frequent alterations in the ubiquitin-mediated proteolysis pathway.

Ferroelectric topological defects show emerging exotic physical properties, which are important for future nanoelectronic devices. Here, the authors demonstrate conductive metallic conduction channels in two types of topological defects, namely vortex and center cores.

BES1 and BZR1 transcription factors are activated by the BRI1-BAK1 receptor complex during brassinosteroid signaling. Here the authors show that BES1-family members also act in anthers, downstream of another receptor-like kinase-mediated signaling pathway, EMS1-TPD1-SERK1/2, to promote tapetum development.

Robust, fast, and low-power hardware platforms are desirable for the implementation of real-time machine vision. Here the authors develop a computing-in-sensor network using ferroelectric photo sensors with remanent-polarization-controlled photo responsivities.

While reservoir computing can process temporal information efficiently, its hardware implementation remains a challenge due to the lack of robust and energy efficient hardware. Here, the authors develop an all-ferroelectric reservoir computing system, showing high accuracies and low power consumptions in various tasks like the time-series prediction.

In optimally doped Nd_0.8Sr_0.2NiO₂H epitaxial film, combined state-of-the-art experimental and theoretical approaches show abundant hydrogen with zero resistivity, and its critical role in superconductivity in epitaxial infinite-layer nickelates.

Platinum based drugs like cisplatin are common chemotherapy treatments for cancer. Here, the authors report on the in situ formation of platinum nanoparticles in patients and demonstrated how platinum nanoparticles can be synthesized using patients’ blood and provide effective drug delivery and cancer treatments.

Zhang et al. have data suggesting that, in the chicken embryo, monocytes foster a pro-angiogenic microenvironment in advance of angiogenesis by depositing migrasomes enriched in angiogenic factors.

2D and 3D conductive MOFs have performed well in the fields of energy and catalysis. Here, authors synthesise a 1D conductive MOF in which DDA ligands are connected by double Cu ions, forming nanoribbon layers with π-d conjugated nanoribbon planes and out-of-plane π-π stacking, which facilitates charge transport along two dimensions.

Cao et al. show that miR-122 encapsulated in breast cancer-derived extracellular vesicles targets PKM to downregulate β-cell insulin secretion, leading to dysregulated glucose homeostasis and enhanced tumour growth.

Solution-based synthesis of covalent organic frameworks (COFs) often leads to insoluble powders or fragile films on solution surfaces. Here, the authors report large-area two-dimensional (2D) COF films with controllable thicknesses via vapour induced conversion.

Existing apple genome assemblies all derive from Golden Delicious. Here, the authors combine different sequencing technologies to assemble a high quality genome of an anther-derived homozygous genotype HFTH1 and find the association of a retrotransposon and red fruit colour.

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and M. tuberculosis.