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A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

A multi-layer wafer-scale 2D gate-all-around system with an atomically smooth interface fabricated via epitaxial monolithic 3D integration shows good performance and power efficiency, holding promise for the forthcoming ångström technology node.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

This Review explores Bi₂O₂Se as a promising 2D semiconductor for next-generation computing, highlighting its high mobility, suitable bandgap and native high-κ oxide, which enables wafer-scale integration and compatibility with industrial processes, while addressing key challenges in the lab-to-fab transition and proposing a roadmap for ultra-scaled, energy-efficient electronics.

High-quality, non-layered 2D β-Bi₂O₃ crystals are grown using a vapour–liquid–solid–solid growth technique. These crystals demonstrate promising properties for p-channel field-effect transistors.

An atomically thin high-κ gate dielectric of Bi₂SeO₅ can be formed via layer-by-layer oxidization of an underlying two-dimensional semiconductor, allowing high-performance field-effect transistors and inverters to be fabricated.

Carbon capture technologies often consume substantial amounts of heat and require multiple steps to release CO₂ and regenerate the absorbent. Here the authors report one-step electrochemical regeneration of CO₂ and alkaline absorbent from (bi)carbonate solutions using a porous solid electrolyte reactor.

Few-layer-thick 2D materials offer desirable electronic, thermal and mechanical properties, but their large-scale layer-controlled synthesis is still challenging. Here, the authors report an edge-feeding synchronous epitaxial growth method to synthesize homogeneous A3-sized graphene films with controlled thickness between 2 and 7 layers.

The authors present Compressed Ultrafast Planar Polarization Anisotropy Imaging, capturing real-time, wide-field, non-invasive measurements of molecular size in liquids and gases. The method could enable scientists to visualize dynamic processes like drug binding and nanoparticle formation.

Transparent conductive electrodes are widely used in modern optoelectronic devices, but they are rarely transparent in the near-infrared, limiting their use. Nanostructured bismuth selenide, a topological insulator, is now shown to be a flexible near-infrared transparent electrode.

In Bi₂O₂Se thin films, the local inversion-symmetry breaking in two sectors of the [Bi₂O₂]²⁺ layer yields opposite Rashba spin polarizations, which compensate each other and give rise to the hidden Rashba effect. Hence, the films exhibit only even-integer quantum Hall states, but there is no sign of odd-integer states.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Liu et al. developed a framework called ARNLE to explore host tropism of SARS-CoV-2 and found a shift from weak to strong primate tropism. Key mutations involved in this shift can be analysed to advance research on emerging viruses.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

Magnetization reversal in magnetic topological insulators drives quantum phase transitions between quantum anomalous Hall, axion insulator, and normal insulator states. Using novel analysis protocol, the authors investigate critical behaviours of these transitions and establish their electronic origin.

Two-dimensional (2D) bismuth oxyselenide crystals with suitable electronic band-gap and ultrahigh carrier mobility enable near-infrared photodetection. Here, the authors report an infrared photodetector based on 2D-bismuth oxyselenide with high responsivity, ultrafast photoresponse of ~ 1 ps at room temperature and a detectable frequency limit of up to 500 GHz.

Su et al. report that the super-enhancer K5aSE orchestrates Klf5andadditional targets via 3D chromatin interactions in ES cells, with CTCF-mediated chromatin domains maintaining this regulatory network essential for ES cell identity.

The ultraviolet-assisted intercalative oxidation of high-mobility two-dimensional semiconductor Bi₂O₂Se can be used to create a single-crystalline native oxide dielectric—β-Bi₂SeO₅—that can yield top-gated transistors with an equivalent oxide thickness of 0.41 nm.

The long-term stability of perovskite solar cells remains a critical challenge for the commercialization of the technology. Here, the authors adopt a non-noble metal/metal oxide/polymer multiple-barrier to suppress device degradation, achieving long-term stability in encapsulated p-i-n devices.

Here the authors identify genetic loci for asthma in East Asians using multi-trait GWAS. A CD36 missense variant shows protective effects and is validated through multi-omics, offering insights into asthma mechanisms and precision therapy.

Here, trace detection of NO2 is achieved with a 2D Schottky-junction Bi₂O₂Se gas sensor. Simultaneous signals allow for detection in the ppt range, and impedance angle analysis allows for molecular specificity.

The epitaxial synthesis of high-density, vertically aligned arrays of two-dimensional (2D) fin-oxide heterostructures is described, enabling the fabrication of 2D fin field-effect transistors with high electron mobility and desirable low-power specifications.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Xu et al. report reconfigurable phototransistors based on MAPbI₃/Bi₂O₂Se heterostructure, with momentum conservation promotes hot carrier extraction and interlayer carrier transport. Heterotransistor array enables traffic light signal detection under dim light, assisted by YOLOv4 neural network.

Hofmann and colleagues describe the mechanism underlying the therapeutic benefit of combinatorial use of SOS1 and KRAS-G12C inhibitors in the context of KRAS-G12C mutant-driven lung and colorectal cancer.

Here, the authors report the ledge-guided epitaxial growth of high-density 2D Bi₂O₂Se fin arrays and their application for the realization of 2D multi-channel fin field-effect transistors, showing improved on-state currents as the number of integrated channels is increased.

Observation of charge order in the overdoped (Bi,Pb)₂Sr₂CuO_6+δ superconductor using resonant X-ray scattering and angular-resolved photoemission spectroscopy, over a wide temperature range.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

There is interest in methods to extend products shelf-life to reduce food waste. Here, the authors report on an amyloid-like protein coating that extends fruit shelf-life 2-5 times by blocking microbes and moisture loss, preserving nutrients, cutting waste and reducing the need for cold chain storage and transport.

Formation of a stable self-assembled monolayer for high-efficiency perovskite solar cells remains a challenge. Here uniform and stable SAM anchoring is achieved on a hydroxylated indium tin oxide surface, leading to highly efficient and stable perovskite solar cells.

The authors find subtype-specific influenza cross-reactivity patterns, including rapid declines for A(H3N2) within 6 years, sustained responses for A(H1N1)pdm09 and increased cross-reactive responses in humans after repeated A(H3N2) exposure.

The design of active sites in single-atom photocatalysts has a large impact on the catalytic reactivity. Here single-atom Pd–O catalytic sites are engineered by regulating their coordination environments. The Pd–O₃ sites exhibit enhanced activity and selectivity for photocatalytic oxidation of toluene to benzaldehyde.

The authors demonstrate quantum Hall effect in semiconducting layered oxide Bi₂O₂Se. Its unique low mass among the oxides of 0.14 m_e and pronounced layered structure makes Bi₂O₂Se highly susceptible to the quantum confinement effects.

Many of the most sensitive X-ray detectors are based on toxic elements such as lead, limiting their safe applications. Here, the authors report the realization of sensitive X-ray detectors based on solution-grown thick BiI/BiI3/BiI van der Waals heterostructures, showing a detection limit down to 34 nGy s⁻¹ and high stability.

By introducing Ni dopants into monolayer Bi₂WO₆, Bi/O frustrated Lewis pairs, unsaturated W atoms, and Ni active units are formed. The authors show that these units facilitate oxygen species transfer and enhance photocatalytic toluene oxidation.

Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

Achieving both high efficiency and narrow emission in organic light-emitting transistors (OLETs) remains a challenge. Here the authors demonstrate laterally integrated OLETs with an intrinsic microcavity that achieve both enhanced efficiency and narrow emission.

This research establishes a theoretical link between far-field polarization geometry and band topology in non-Hermitian systems, enabling Berry curvature observation through polarimetry. Experimental results from a honeycomb photonic crystal slab confirm the method’s effectiveness in determining valley Chern numbers.

The authors synthesise a Bi-based halide and use it as a photosensitive control gate in a floating-gate transistor, enabling a non-volatile optoelectronic memory with ultra-low energy consumption and large resistive state numbers, for high-accuracy machine learning.

In this work, we introduce programmable memory elements embedded within III-V/Si light sources which facilitate non-volatile wavelength tuning for fast memory search and in-memory computing functions.

Bi₂Te₃ materials suffer from brittleness, limiting their application for thermoelectric harvesting. By depositing ordered nanocrystals onto single-wall carbon nanotubes, a flexible material is formed that achieves ZT of 0.89 at room temperature.

Controlling the spin Hall angle is significant to tunable and energy-efficient spintronic devices. Here, the authors demonstrate that the spin Hall angle in Bi₂Se₃ can be tuned and even enhanced about 600% reversibly by the electric field.