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Zhang, Peng, and colleagues benchmark metabolic RNA labelling chemistries for time-resolved single-cell RNA sequencing, improving in vivo detection of newly synthesized RNA during zebrafish embryogenesis.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Cropland area—and associated carbon dioxide emissions—in 110 studied countries is 6% higher than it would be without declines in agricultural productivity caused by climate change, according to a comparison of models with and without climate impacts.

Formation of a stable self-assembled monolayer for high-efficiency perovskite solar cells remains a challenge. Here uniform and stable SAM anchoring is achieved on a hydroxylated indium tin oxide surface, leading to highly efficient and stable perovskite solar cells.

The authors make local heterogeneous dipolar structures in PbHfO3-based antiferroelectric ceramics, which exhibit a recoverable energy density of 20.04 J cm⁻³ accompany with an efficiency of 90.5%.

Universal properties have previously been observed mostly in the equilibrium physics of many-body systems in the low-energy and low-temperature regime. Now universality is observed at high temperature in the spin dynamics of a solid-state nuclear magnetic resonance system.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

Multi-species acute systemic toxicity assessment is fundamental for chemical classification, labelling and risk management. Here, the authors propose a machine learning paradigm, Adjoint Correlation Learning, yielding significant improvements for data-scarce endpoints and offering a useful computational tool for regulatory applications.

Local shear stress from an atomic force microscope tip can control the crystal directions in thin oxide films. This approach enables the manipulation of local magnetic anisotropy in ferromagnetic metals.

There is interest in methods to extend products shelf-life to reduce food waste. Here, the authors report on an amyloid-like protein coating that extends fruit shelf-life 2-5 times by blocking microbes and moisture loss, preserving nutrients, cutting waste and reducing the need for cold chain storage and transport.

Weakly space-confined, large-grained crystals of all-inorganic perovskite were used to fabricate light-emitting diodes with a high external quantum efficiency and operational stability.

Protein structures are predicted by integrating deep learning potentials with iterative threading fragment assembly simulations.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Heavy metals and plastics are two major environmental pollutants. Here, the authors engineer microbial platforms capable of endogenously biosynthesizing phosphomelanin for simultaneously heavy metals adsorption and plastics degradation.

Observations indicating the chiral nature of superconducting states in five rhombohedral tetralayer and pentalayer graphene devices without moiré superlattice effects are reported, establishing a pure carbon material for the study of topological superconductivity.

The grain boundary diffusion of tungsten is sluggish under the Earth’s core-mantle boundary conditions, and is inefficient in modifying the tungsten isotopic compositions of the deep mantle and the associated terrestrial rocks.

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-purpose dyes for fluorescence biomaging.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Catalysts synthesized by current methods for CO₂ electroreduction to CO exhibit limited activity and selectivity over broad potentials. Here, the authors report an in situ etching method to create NiN₂ sites with uniform-large vacancies that achieve high activity across a wide potential window.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Mapping enhancer-target gene pairs with single-cell multimodal data is challenged by the data’s unique characteristics and computational demands. Here, the authors propose scMultiMap, a statistical method with high statistical power and computational efficiency for inferring their associations.

Flexible distribution networks with soft open points present a promising way to accommodate distributed generators and increasing loads. Here, authors present a multi-resource dynamic coordinated planning method, allowing allocation strategies to be determined over long-term planning periods.

The transfer of 2D semiconductor films remains a challenging step in the fabrication of industry-compatible 2D electronics. Here, the authors report a method based on a Se intermediate layer to facilitate the transfer of wafer-scale MoS₂ monolayers with nearly 100% film intactness and superior surface/interface cleanness, leading to an improved electrical performance of the devices.

The trade-off between dexterity and payload capacity has limited the broad application of advanced aerial manipulation systems. Here, the authors introduce the Aerial Elephant Trunk, an aerial continuum manipulator, capable of performing operations in constrained and densely clustered environments.

Toxic chemicals can transform in the environment, often forming more harmful products. This study provides evidence for the aqueous formation of organophosphate esters (OPEs) in aerosols, highlighting their fate and implications for risk assessment.

Mechanoelectric energy conversion is a potential solution for the power supply of soft devices, but the low current output for low frequency motions limits its applicability. Here, the authors report a hydrogel generator with mechanoionic current generation amplified by orders of magnitudes and its application as controlled drug-releasing system for wound healing.

As a major source of reactive oxygen species, mitochondria face a challenge to maintain their redox state. Here the authors show that ROMO1 overexpression prevents deleterious oxidation of the mitochondrial cysteinome and exerts beneficial effects on mitochondrial function.

Chen et al. introduce an AI-driven method that generates 3D small-molecule drug candidates and outperforms existing approaches by leveraging ligand shape information.

A size-sieved complex precipitation in Sc-added Al–Mg alloys achieves a high-density dispersion of both fine Al₃Sc nanoprecipitates and in situ formed core-shell Al₃(Mg, Sc)₂/Al₃Sc nanophases with high hydrogen-trapping ability.

Magnetization reversal in magnetic topological insulators drives quantum phase transitions between quantum anomalous Hall, axion insulator, and normal insulator states. Using novel analysis protocol, the authors investigate critical behaviours of these transitions and establish their electronic origin.

Solar-powered desalination is a sustainable approach to generate clean water for our society. Here, authors report lightweight, flexible, and fluidic-diode membrane-based evaporators to allow directional water transport and optimized heat localization. This Janus evaporator design enables high performance interfacial solar water evaporation, as well as hydrovoltaic applications.

An acceptor–donor–acceptor organic semiconductor enables near-infrared organic light-emitting diodes with reduced efficiency roll-off over six orders of magnitude of excitation current density, enabling a maximum luminance of 2,000 W sr⁻¹ m⁻².

Transfer hydrogenation is challenging to apply to aryl halide reductive cross-couplings because of competing hydrogenolysis. Now aryl halide cross-couplings mediated by sodium formate have been developed. These processes display orthogonality to Suzuki and Buchwald–Hartwig couplings as pinacol boronates and anilines are tolerated and, owing to chelated intermediates, effective for challenging 2-pyridyl systems.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.