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Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

Understanding past warming events is essential to project the consequences of anthropogenic carbon emissions. Here, carbon and hydrological cycle changes of the Carnian Pluvial Episode are revealed, offering insights into Earth System functioning.

Concise and enantioenriched synthesis of chiral carbocyclic and heterocyclic spirane scaffolds is a significant objective in both academic and industrial fields. Here, the authors report the kinetic resolution of racemic spirocyclic 1,3-diketones and their analogues via catalytic asymmetric hydrogenation with the SPA-PNN ligands.

This study reports the design of heterogated nanoprobes for interval-based pH imaging in biological systems, including cellular endocytic organelles and tumours. The modular design allows for fine-tuning of pH transition point and fluorescent emission.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Nanotwinned ceramic chromium nitride (NT-CrN) is prepared by precisely controlling the deposition ion energy, which demonstrates high hardness (>36 GPa) with room-temperature compressive plasticity exceeding 40% without brittle fracture.

Compiling data on floral introductions and European colonial history of regions worldwide, the authors find that compositional similarity of floras is higher than expected among regions once occupied by the same empire and similarity increases with the length of time the region was occupied by that empire.

The study of isotopes away from the beta stability valley is crucial for the understanding of nuclear structure, especially for neutron-deficient heavy nuclei. Here, the authors report the observation of the alpha-decay isotope 210-protactinium (Pa), extending the alpha-decay systematics of underexplored regions of the nuclides chart.

Comprehensive single-cell transcriptomic analysis of 35 human tissues reveals 12 cross-tissue coordinated cellular modules that exhibit intramodule communication and dynamic changes with ageing, and whose organization is perturbed during cancer progression.

Transition metal compounds provide a versatile platform for tailoring Mott physics. Here, the authors reveal that hybridization between the lower Hubbard band and the chalcogen band stabilizes the Mott state through bandwidth tuning in the 1T-MX₂ (M = Nb, Ta; X = S, Se) family.

A universal, high-resolution printing technology for metal oxide thin-film transistors is still lacking. A plasmonic printing technology is reported to fabricate high-performance, solution-processed all-metal oxide thin-film electronics under room temperature and ambient conditions.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

High mobility group A1 (HMGA1) has been identified to play a role in tumour progression but its involvement in anti-tumour immunity of esophagael squamous cell carcinoma (ESCC) remains unclear. Here the authors report that the inhibition of STING-mediated anti-tumour immunity by HMGA1 results in promotion of ESCC tumorigenesis.

Efficient CO₂ electroreduction to C₂₊ products at high current densities remains a significant challenge. Here, the authors develop inherently hydrophobic and hierarchically porous Cu supraparticles with enhanced mass transfer and abundant C-C coupling sites for ampere-level CO₂-to-C₂₊ synthesis.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Li et al. demonstrate the critical role of skeletal muscle stem cells (MuSCs) in actively shaping their niche in dystrophic muscle through YY1-CCL5-CCR5 axis mediated cellular interaction with macrophages.

Light at low power densities can be used to manipulate ferromagnetic domains in the two-dimensional van der Waals ferromagnet Fe₃GeTe₂. This capability could be used to engineer the behaviour of Fe₃GeTe₂-based devices.

In superconductors with sign-preserving pairing symmetries, Cooper pairs break when they scatter off magnetic impurities but not non-magnetic impurities. An observation of pair breaking by copper impurities in Na(Fe_0.96Co_0.03Cu_0.01)As demonstrates that its pairing symmetry is sign-reversed.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Humans have altered plant biogeography by introducing species from one region to another, but an analysis of how naturalized plant species affect the uniqueness of regional floras around the world was missing. This study presents an analysis using data from native and naturalized alien floras in 658 regions, finding strong taxonomic and phylogenetic floristic homogenization overall.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

Plasma cell differentiation is governed by a gene expression program, for which transcriptional regulators are mostly known but other regulatory elements, such as RNA-binding proteins remain lesser explored. Here authors show that an RNA-binding protein complex, Csde1-Strap, regulates the window of Bach2 expression, a transcription factor necessary for the transient expansion of B cells preceding plasma cell differentiation, via coupling its translation to its decay.

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

C–C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecular structures. Herein, the authors report a method to achieve amidation of aryl C(sp2)–H bonds by cleavage and recombination of C–C triple bonds with the participation of nitrous acid esters.

The role of the low velocity-high conductivity zones (LV–HCZs) in developing the Tibetan Plateau has remained controversial. Here, Wang et al.present new geochemical and petrological data that show the LV–HCZs are sources of partial melt thus giving insight into the development of the Tibetan Plateau.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

An annually resolved 3476-year tree-ring record from the Tibetan Plateau reveals severe 20^th century droughts and highlights the interplay between the Asian Monsoon and Westerlies. Droughts are often linked to the collapse of dynasties.

Moiré patterns and flat bands usually occur in multilayer materials with a small interlayer twist angle, but this can cause detrimental lattice reconstruction. Now, flat bands are shown in a bilayer with large twist angle and structural rigidity.