Nature Search

PPP2R1A mutations portend improved survival after cancer immunotherapy

Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathway may represent an effective startegy for improving responses to immunotherapy.

Yibo Dai
Anne Knisely
Amir A. Jazaeri
ResearchOpen Access02 Jul 2025
Nature

P: 1-10
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Maria Zanti
Denise G. O’Mahony
Kyriaki Michailidou
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-18
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations

Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Nilanjana Sadhu
Rinkoo Dalan
John C. Chambers
Research13 May 2025
Nature Cardiovascular Research

Volume: 4, P: 567-583
Structural plasticity broadens the specificity of an engineered protease

Roger Bone
Joy L. Silen
David A. Agard
Research18 May 1989
Nature

Volume: 339, P: 191-195
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Tissue factor-dependent colitogenic CD4⁺ T cell thrombogenicity is regulated by activated protein C signalling

Patients with inflammatory bowel disease (IBD) have increased risk for venous thromboembolism, but mechanistic insight is still lacking. Using both mouse experimental colitis models and IBD patient biopsies, here the authors implicate increased tissue factor activity on colitogenic T cells as a potential link.

Gemma Leon
Paula A. Klavina
Roger J. S. Preston
ResearchOpen Access16 Feb 2025
Nature Communications

Volume: 16, P: 1-14
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma

Shou-Jiang Gao
Lawrence Kingsley
Patrick S. Moore
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 925-928
Desiccation of Eggs of the Crane Fly (Tipula oleracea, L.)

ROGER LAUGHLIN
Research30 Aug 1958
Nature

Volume: 182, P: 613
The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation

Marc G Weisskopf
Robert A Zalutsky
Roger A Nicoll
Research01 Apr 1993
Nature

Volume: 362, P: 423-427
Correction: Corrigendum: Direct multiplexed measurement of gene expression with color-coded probe pairs

Gary K Geiss
Roger E Bumgarner
Leroy Hood
Amendments and Corrections01 Jun 2008
Nature Biotechnology

Volume: 26, P: 709
Microsatellite mapping of a gene affecting horn development in Bos taurus

Michel Georges
Roger Drinkwater
Jay Hetzel
Research01 Jun 1993
Nature Genetics

Volume: 4, P: 206-210
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

Citizen science taps the efforts of non-experts. Here, authors describe Drugit, an extension of the crowdsourcing game Foldit, and its use in designing a non-peptide binder of Von Hippel Lindau E3 ligase for use with proteolysis targeting chimeras.

Thomas Scott
Christian Alan Paul Smethurst
Rocco Moretti
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Creativity supports learning through associative thinking

Simone A. Luchini
James C. Kaufman
Roger E. Beaty
ResearchOpen Access01 Jul 2025
npj Science of Learning

Volume: 10, P: 1-12
Long-distance coherent quantum communications in deployed telecom networks

A twin-field quantum key distribution protocol based on optical coherence is deployed over a 254-kilometre commercial telecom network, demonstrating that coherence-based quantum communication can be aligned with existing telecommunication infrastructure.

Mirko Pittaluga
Yuen San Lo
Andrew J. Shields
Research23 Apr 2025
Nature

Volume: 640, P: 911-917
Loss of functional K_ATP channels in pancreatic β–cells causes persistent hyperinsulinemic hypoglycemia of infancy

Charlotte Kane
Ruth M. Shepherd
Mark J. Dunne
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1344-1347
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial

In a phase 1b trial, treatment of patients with muscle-invasive bladder cancer with intravesical oncolytic virus cretostimogene grenadenorepvec in combination with nivolumab was safe and led to encouraging preliminary clinical response rates.

Roger Li
Nancy Y. Villa
Jose R. Conejo-Garcia
Research09 Nov 2024
Nature Medicine

Volume: 31, P: 176-188
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Prevention of Rapid Immune Elimination of Anti-lymphocytic Globulin in Transplant Patients

WILLIAM T. BUTLER
ROGER D. ROSSEN
VERNON KNIGHT
Research29 Nov 1969
Nature

Volume: 224, P: 856-860
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Leming Shi
Wendell Jones
Weida Tong
ResearchOpen Access02 Jul 2007
Nature Precedings

P: 1
Understanding the genetic complexity of puberty timing across the allele frequency spectrum

A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

Katherine A. Kentistou
Lena R. Kaisinger
Ken K. Ong
ResearchOpen Access01 Jul 2024
Nature Genetics

Volume: 56, P: 1397-1411
The triple QSO PG1115 + 08: another probable gravitational lens

Ray J. Weymann
David Latham
J. Anthony Tyson
Research26 Jun 1980
Nature

Volume: 285, P: 641-643
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactivate BRISC, promoting interferon receptor ubiquitylation and degradation to dampen immune responses.

Francesca Chandler
Poli Adi Narayana Reddy
Elton Zeqiraj
ResearchOpen Access17 Mar 2025
Nature Structural & Molecular Biology

P: 1-13
Radio caustics from localized interstellar medium plasma structures

Roger W. Romani
Roger D. Blandford
James M. Cordes
Research23 Jul 1987
Nature

Volume: 328, P: 324-326
Effectiveness of bioremediation for the Exxon Valdez oil spill

James R. Bragg
Roger C. Prince
Ronald M. Atlas
Research31 Mar 1994
Nature

Volume: 368, P: 413-418
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Leming Shi
Wendell Jones
Weida Tong
ResearchOpen Access03 Jul 2007
Nature Precedings

P: 1
Increasing the presence of BIPOC researchers in computational science

Nature Computational Science asked a group of scientists to discuss strategies for increasing the presence of Black, Indigenous, People of Color (BIPOC) researchers in computational science, as well as the various considerations to be made for improving education and methods design.

Christine Yifeng Chen
Alan Christoffels
Karaitiana Taiuru
Reviews24 Sept 2024
Nature Computational Science

Volume: 4, P: 646-653
The contribution of de novo coding mutations to meningomyelocele

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

Yoo-Jin Jiny Ha
Ashna Nisal
Joseph G. Gleeson
Research26 Mar 2025
Nature

Volume: 641, P: 419-426
Swimming rats and human depression (reply)

ROGER PORSOLT
MAURICE JALFRE
Research03 Aug 1978
Nature

Volume: 274, P: 512-513
Non-rejoining DNA breaks and cell inactivation

DUDLEY T. GOODHEAD
JOHN THACKER
ROGER COX
Research01 Mar 1978
Nature

Volume: 272, P: 379-380
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Fertile addition

Roger Gosden
Books & Arts04 Apr 1996
Nature

Volume: 380, P: 402
Cancer risk and electromagnetic fields

Adam Lacy-Hulbert
Roger C. Wilkins
James C. Metcalfe
Research04 May 1995
Nature

Volume: 375, P: 23
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
C2 ___domain conformational changes in phospholipase C-δ1

Jay A. Grobler
Lars-Oliver Essen
James H. Hurley
Research01 Sept 1996
Nature Structural Biology

Volume: 3, P: 788-795
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs

Barry J. Cooper
Nena J. Winand
James E. Sylvester
Research14 Jul 1988
Nature

Volume: 334, P: 154-156
Realization of a three-dimensional spin–anisotropic harmonic honeycomb iridate

The spin–orbit interaction and the two-dimensional honeycomb structure of iridium-based oxides are promising for exotic electronic states. Here, the authors find an iridium oxide with a three-dimensional structure that preserves the features of the honeycomb systems, creating new material possibilities.

K. A. Modic
Tess E. Smidt
James G. Analytis
Research27 Jun 2014
Nature Communications

Volume: 5, P: 1-6
Cell biology: An unfolding story of protein translocation

James E. Rothman
Roger D. Kornberg
News & Views17 Jul 1986
Nature

Volume: 322, P: 209-210
Highs and hopes

Roger Guillemin
Books & Arts05 Jan 1989
Nature

Volume: 337, P: 26-27
Localized Areas of High Alkaline Phosphatase Activity in Endothelium of Arteries

FLAVIU C. A. ROMANUL
ROGER G. BANNISTER
Research11 Aug 1962
Nature

Volume: 195, P: 611-612
Maximize the impacts of space science

Put research goals first when prioritizing and managing national and international projects, urge Ji Wu and Roger Bonnet.

Ji Wu
Roger Bonnet
Comments & Opinion20 Nov 2017
Nature

Volume: 551, P: 435-436
Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Veronica Torrano
Lorea Valcarcel-Jimenez
Arkaitz Carracedo
Amendments and Corrections29 Jun 2017
Nature Cell Biology

Volume: 19, P: 873

Search

Filter By:

Search

Quick links