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NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

Spatiotemporally activating DC cells in lymph nodes (LN) for cancer vaccine therapy remains a challenge. Here the authors combine antigen loaded STING nanoadjuvants with LN-confined laser or ultrasound stimulation to activate DC cells, sequentially enhances antigen-specific CD8⁺ T cell response and reduces tumor size.

Ion transport properties are critical to some emerging technologies. Here, the authors show the controllable 2D movement and redistribution of Li-ions in metal oxides such as WO₃ by a magnetic field. The success is based on a current-driving model which also works for other cations including H⁺, Na⁺, Zn²⁺ and Ca²⁺.

Stable inorganic solid-state electrolytes are crucial for reliable all-solid-state battery development. Here, the authors report a Li-In|Li_6.8Si_0.8As_0.2S₅I|Ti₂S lab-scale cell with a long cycle life of almost 62500 cycles at 2.44 mA cm⁻², 30 °C and 30 MPa.

Sensing of cytosolic RNA or DNA can lead to innate responses, but little information is available for RNA/DNA dual sensors. Here the authors find SAMD9 as a potential dual sensor linked to pro-inflammatory responses, interferon induction and resistance to viral infection, as evidenced by in vitro overexpression and in vivo knockout mouse data.

Ion trapping has been found to be responsible for the performance degradation in electrochromic oxide thin films. This paper visualizes ion trapping and detrapping dynamics, and provides a general picture of electrochromism in amorphous WO₃.

Polymer electrolytes based on poly(vinylidene fluoride) with residual solvents are appealing for room-temperature battery operations. Here, the authors present a phase regulation approach to achieve a dense electrolyte and enhance ionic conductivity through the incorporation of MoSe₂ sheets.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Solid-state electrolytes lie at the heart of the development of solid-state batteries that offer a promising storage technology. Yong-Sheng Hu and colleagues report a class of viscoelastic inorganic glass featuring merits of both inorganic crystalline electrolytes and organic polymer electrolytes and demonstrate pressure-less Li- and Na-based solid-state batteries.

LiCoO₂ is a cathode material widely used in lithium-ion batteries but suffers from solubilization of cobalt and structural disorder when the voltage is increased to release more capacity. Here the authors show a ternary Li, Al and F-modified LiCoO₂ and battery cells with stable cycling behavior over 4.55 V.

Myocardial infarction treatment strategies remain challenged in effectiveness. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles near the disease area for in situ localized treatment.

In this work, authors present a supramolecular fluorescent sensor array that enables the accurate discrimination of intracellular bacteria, also demonstrating that this can be modified as a host-guest drug delivery system to combat these bacteria.

Transition metal dichalcogenides exhibit diverse and tunable electronic states. Here the authors reveal a cascade of phase transitions upon increasing hydrostatic pressure in the few-layer 1T’-WS₂, including a re-entrant superconducting phase emerging from a normal state exhibiting anomalous Hall effect.

In-phase/quadrature (IQ) electro-optic modulators are underpinning devices for coherent transmission technology. Here the authors present IQ modulators in the lithium-niobate-on-insulator platform, which provide improved overall performance and advanced modulation formats for future coherent transmission systems.

Whether topologically protected electron moving and photon moving can couple each other remains an interesting question. Here, Luo et al. report reversion of photon spin and the direction of the photocurrent in a topological insulator by changing light propagation direction.

Cost-efficient electrolytes are important for the development of multivalent metal batteries, but expensive precursors and complex synthesis hinder progress. The authors present a cation replacement method for low-cost, high-reversibility magnesium and calcium electrolytes, advancing high-energy-density multivalent metal batteries.

Orbital-angular-momentum (OAM) beams have great potential for multiplexing signals in optical communication, but creating a compact source is challenging. The authors integrate a chip-scale optical vortex emitter and DFB laser into a single monolithic device for direct electrically pumped production of OAM beams.

Prosthetic knees face challenges in meeting user ambulation and comfort needs, with soft materials offering potential solutions but being constrained by their limited load-bearing capacity. Here, the authors innovate a soft prosthetic knee for transfemoral amputees.

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Qu et al. report a self-assembled material with π-expanded conjugation to form hydrophilic ordered bilayer as hole selective layer for inverted perovskite solar cells. The enhanced interfacial charge extraction and transport enable certified efficiency of 26.39% and 25.21% for 7.15 mm² - and 99.12 mm² -devices, respectively.

Silencers play a critical role in gene transcription regulation. Here, the authors developed the Ss-STARR-seq technique to identify tens of thousands of silencers in human cells. These silencers possess unique epigenetic features and are capable of influencing cellular phenotypes.

Low-loss, high-speed and efficient optical modulators on a silicon platform are demonstrated.

Factors that determine the cellular tropism of SARS-CoV-2 beyond the host cell receptor, ACE2, are poorly defined. Here, the authors show that tonic activation of the cGAS-STING sensing pathway potently blocks SARS-CoV-2 replication in a subset of ACE2-expressing airway-derived cells.

A genome-wide study based on three-dimensional facial images identifies new loci associated with facial morphology in East Asian populations. Comparison with data from European populations identifies variants related to facial shape differences between these populations.

Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.

The recent observation of superconductivity in nickelate thin films has attracted a lot of attentions. Here, authors report single particle tunneling spectra on the superconducting nickelate thin films revealing two types of gap feature with one V-shape and the other a full gap.

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

The amino acid transporter complex LAT1-4F2hc is considered a major drug target for many cancers. Here, the authors apply native mass spectrometry-based approaches to decode a complete LAT1-4F2hc assembly. To do this, they connect post-translational modification and endogenous phospholipid binding to super-dimerization, function and localisation of LAT1-4F2hc.

Generic synthesis of metal-N4 moieties is interesting but challenging. Here the authors report an interfacial-fixing strategy to prepare neighboring metal-N4 sites, such as Fe2-N6, for oxygen reduction reaction.

Jiang et al. document an abundance of neutrophil-derived migrasomes in the blood of mice and humans and show that migrasomes are enriched in coagulation factors, accumulate at sites of injury and trigger platelet activation and clot formation.

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Disturbing the redox balance in anaerobic bacteria presents a promising but underdeveloped strategy for the treatment of difficult-to-cure diseases caused by anaerobic bacteria. Here, the authors report a photocatalytic system to perturb the redox balance in oxygen-free conditions, achieving photocatalytic therapy to treat periodontitis.

Osteocytes are the key cellular components of cortical bone. Here they show that osteocytes transfer mitochondria to the endothelial cells of transcortical vessels (TCVs), which promotes angiogenesis and increases function of the TCV network.

Liquid biopsy assays are important to prognosticate outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients treated with androgen receptor (AR) inhibitors. Here this group reports detecting circulating tumor DNA in limiting plasma cell-free DNA of mCRPC patients as prognostic marker of poor survival after AR treatment.

A two-dimensional perovskite, Sr₂Nb₃O₁₀, can be integrated with a range of other two-dimensional materials and act as a photoactive high-κ dielectric in the resulting phototransistors.