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Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

Here the authors show that viral infections facilitate accumulation of cellular iron by degradation of iron exporter ferroportin (FPN1), and that high intracellular iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation.

The authors present a chip-less wearable sensor-processor integrated neuromorphic system that combines multimodal physicochemical sensing with neuromorphic processing for real-time, autonomous physiological monitoring.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Rehmannia chingii is a traditional Chinese medicinal plant that can produce iridoid glycoside. Here, the authors report its genome assembly and the elucidation of the iridoid biosynthetic pathway.

The authors demonstrate resonant excitation of phonon-polaritons based on THz-driven ZnO single crystals. This clarifies the generation mechanism of phonon-polaritons, enabling their observation for various nonlinear regimes.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

Song et al. report stochastic edge detection enabled by integrating memristor-based stochastic number encoders with logic gates to perform bitwise logic operations with statistical probabilities. A hardware Roberts cross operator achieves 95% less computational cost while withstands up to 50% bit-flip errors.

Gene isoforms are quantified with a machine learning method that optimally integrates long and short sequencing reads.

Developing robotic hands that can adapt to real-world dynamics remains a substantial challenge. The authors present an AI system that mimics human-like grasping using full-hand tactile sensing and a sensory–motor feedback mechanism.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

Many countries are relying on land-based strategies to meet the climate targets set out in the Paris Agreement, putting pressure on land resources. Here the authors show a global reduction in cropland area under current climate pledges, with implications for trade and food security.

Age-related hearing loss (ARHL) is a prevalent and complex disorder in older adults. Guo et al. identify human antigen R as a regulator of ARHL in aged mice and demonstrate that cochlear human antigen R overexpression alleviates ARHL, highlighting it as a therapeutic target for the condition.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Alpine plants exhibit phenological adaptations to germinate and complete their reproductive cycles during the most favorable growing seasons. Here, the authors show that allelic variation in the GA20ox3 gene is crucial for the adaptability of fruit length and seed germination timing in high-altitude ecotypes of A. thaliana.

This study evaluates bias in AI-generated medical text, revealing disparities across race, sex and age. An optimization method is proposed to enhance fairness without compromising performance, offering a step toward more equitable AI in healthcare.

Membranes which extract lithium are critical to developing sustainable technologies. Here, the authors report a covalent organic framework featuring randomly oriented channels, separating lithium from a mixture of cations.

APOL9a/b proteins coat mouse intestinal bacteria with high specificity, and genetic abolition of ceramide-1-phosphate synthesis pathways in the symbiote Bacteroides thetaiotaomicron significantly decreases this binding of APOL9a/b to the bacterium.

Rhizosphere viruses mediate arsenic (As) biogeochemistry by promoting lysogeny in As-oxidizing microbes. Metagenomics, metabolic modeling, and in vitro experiments estimate rhizosphere lysogenic viruses contribute to up to 25% of microbial As oxidation.

Kaposi’s sarcoma-associated herpesvirus changes mitochondrial architecture via vBcl-2 interaction with a host NDP kinase, which triggers mitochondrial fission and inhibition of MAVS allowing for virus production.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

The key challenge in liquid organic hydrogen carriers (LOHCs) is preventing catalyst poisoning by CO in crude H₂. Here the authors present a Pd/α-MoC catalyst that enables efficient N-LOHC hydrogenation under crude H₂ (CO > 5 vol%) below 150 °C, achieving activity 1–2 orders of magnitude higher than conventional Pd-based catalysts.

A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

Quantum speed limits are fundamental constraints on the speed of quantum state evolution. Here, the authors observe the known maximal quantum speed limits for few and many-body states on a superconducting quantum processor and identify the minimal quantum speed limits, which are less common than maximal ones.

The authors present a reference genome for Hordeum I-genome species. This work unravels genomic features that drive adaptation to salt and alkali environments and could aid in improving crop resilience.

Disorder has emerged as a promising tool to manipulate properties of superconducting circuits. Here the authors demonstrate the use of disordered spinodal superconductor for fluxonium qubit fabrication and reveal an interesting correlation between the material disorder and the 1/f-type flux noise.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

A non-contact wearable device that defines and modulates a microclimate adjacent to the skin can measure incoming and outgoing streams of vapourized substances, offering valuable insights into physiological health, wound healing and environmental exposures.