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The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

A Co-doped ZnO catalyst is developed to break charge symmetry at active sites, promoting the activation of peroxymonosulfate to generate nonradical species for efficient removal of electron-rich pollutants in complex water environments.

Sequence-based algorithms to identify T cell antigens often miss targets that are activating the immune response. Here authors show that a computational method they developed, which uses atomic level features as input, can identify antigens that trigger cytokine release in cognate T cells.

The authors make local heterogeneous dipolar structures in PbHfO3-based antiferroelectric ceramics, which exhibit a recoverable energy density of 20.04 J cm⁻³ accompany with an efficiency of 90.5%.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

White-light emission from materials and devices usually occurs omni-directional through space. Here, the authors show that sintering carbon dots with TiO₂ forms a microlens-shape surface that enables directional emission with 1/60 solid angle.

Acetylation is a posttranscriptional modification widely distributed across RNA types. Here, the authors uncover the role of tRNA ac⁴C12 for translational efficiency and tRNA quality control in both normal and heat stress conditions in mammalian cells.

The authors report an ultra-broadband ptychography method, suitable for dispersive samples, by exploiting structured illumination and a novel joint deconvolution algorithm.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Dong et al. achieve Sb₂(S,Se)₃ solar cells with 10.7% efficiency by increasing charge generation with a textured electrode and reducing charge recombination and transport loss with a conformal electron-selective layer.

Drought, fires, and human activities have reversed the accumulation of live biomass carbon in the Northern Hemisphere, with total biomass shifting from a positive to a negative trend around 2016.

Here they identify a selective PRC1.1 inhibitor, iBP, that treats bone loss by improving osteoblast function. iBP releases repression of Wnt/β-catenin signaling, enhancing bone formation and repair in aging, trauma, and disease models.

AI applications on mobile devices are constrained by the high resource demands of large models. Here, the authors developed an efficient on-device multimodal embedding system.

Xue et al. report self-powered photoelectrochemical photodetectors based on CuOx decorated AlGaN nanowires with staggered energy band structure. High-energy photons can be absorbed by CuOx to trigger the multiexciton generation effect, enabling an external quantum efficiency of 131.5% at 255 nm.

Although Brønsted base-mediated [1,2]- phospha-Brook rearrangements have garnered considerable attention in the development of new methodologies, the strict reliance on pentavalent phosphonates imposes strong limitations on new reaction types. Here, the authors disclose a Lewis acid-mediated trivalent [1,2]- phospha-Brook rearrangement with carbonyl compounds to rapidly access tertiary phosphine oxides.

This study reveals that over half of China’s steel units lack sufficient renewable energy for hydrogen-based direct reduced iron technology. Aggressive deployment would increase carbon emissions, economic costs, and water usage in the steel sector.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

The RNA binding protein hnRNPL is recruited to chromatin by the PIK3CB promoter-transcribed non-coding RNA and forms phase-separated condensates, which activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression.

The phenol industry faces a pressing sustainability challenge from the production of acetone as a by-product at a level far beyond its market. Here the authors develop an electro-biosystem that can efficiently convert such surplus acetone into valuable long-chain commodity chemicals.

Understanding the dynamic evolution of heterogeneous catalysts is crucial yet challenging. This work uncovers the transformation of amorphous PtIn clusters into ultrafine Pt₃In intermetallics, driven by propylene during propane dehydrogenation, highlighting the pivotal role of product-induced changes in revealing the true active sites.

Polygenic scores aim to capture genetic risk but may miss nonlinear genetic and environmental interactions. Here, the authors show that neural networks detect limited nonlinearity and do not outperform linear models, highlighting constraints in current deep-learning approaches.

Mapping the N⁶-methyladenosine (m⁶A) transcriptome in prostate cancer has established its clinical potential value as a prognostic biomarker for this disease. A multidisciplinary approach that integrates genomics, transcriptomics, epitranscriptomics, proteomics and clinical oncology is essential to translate the intricacies of m⁶A modification into tangible benefits for patients

Doping of Nb₂O₅ materials without phase changes has been proven difficult, with successful doping depending on different factors such as ionic radius similarity. In this work, the authors introduce a high-entropy-doping approach to Nb₂O₅ without phase change with rapid-charging capabilities as a negative electrode for lithium-ion batteries.

Land surface modelling suggests that preserving woody debris in managed forests could remove 769–937 GtCO₂ from the atmosphere between 2025 and 2100.

Electrostatic effects of separators under internal electric field is crucial for Li metal batteries. Here, authors develop a high dielectric constant fiber separator that shows substantial polarization under electric field to facilitate a robust and low-resistance solid-electrolyte interphase.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

Broadband terahertz emission from a two-dimensional van der Waals ferroelectric semiconductor, NbOI₂, offers opportunities towards nanoscale near-field terahertz spectroscopy and in situ probing of quantum collective excitations in two-dimensional materials.

The Mass Spectrometry Query Language (MassQL) is an open-source language that enables instrument-independent searching across mass spectrometry data for complex patterns of interest via concise and expressive queries without the need for programming skills.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

This study presents an anionic high-entropy doping strategy, elucidating the intricate charges state regulation to drive dipole polarization-dominated dielectric loss and efficient electromagnetic wave absorption in thin graphite framework.

The acetylene hydrogenation activity and stability of a palladium single-atom catalyst are both controlled by the lowest unoccupied molecular orbital of the oxide support.

Chromogranin A (CgA) ablation in Tauopathy mice reduces toxic Tau buildup, reverses cognitive decline and improves lifespan. Mechanistically, the deletion of CgA normalizes the adrenergic signaling axis in the brain.

Olefin-linked covalent organic frameworks are materials with potential application as organic semiconductors, but their synthesis remains challenging. Now, single-crystal sp²-carbon-linked covalent organic frameworks have been prepared through an imine-to-olefin transformation strategy; the resulting materials feature enhanced room-temperature metal-free ferromagnetism.