Nature Search

Natural variation in the promoter of qRBG1/OsBZR5 underlies enhanced rice yield

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

Qiuli Zhang
Renhong Wu
Fangming Zhao

ResearchOpen Access03 Oct 2024

Nature Communications

Volume: 15, P: 1-19

Rescuing dendritic cell interstitial motility sustains antitumour immunity

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

Haichao Tang
Zongfang Wei
Ting Zhou

Research25 Jun 2025

Nature

P: 1-10

Author Correction: The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid

Ting Zhou
Jie Cheng
Ding Ai

Amendments and Corrections20 Jun 2025

Nature Metabolism

P: 1

Author Correction: Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Defang Li
Jin Liu
Ge Zhang

Amendments and CorrectionsOpen Access19 Jun 2025

Nature Communications

Volume: 16, P: 1-3

Rapid formation of stable autotetraploid rice from genome-doubled F1 hybrids of japonica–indica subspecies

This study details a process of duplicated (homoeologous) chromosome ‘scrambling’ in newly formed rice polyploids, indicating the possibility of natural ‘allo-to-autopolyploid’ evolution, with implications for polyploid crop breeding.

Xu Han
Jiahao Li
Bao Liu

ResearchOpen Access31 Mar 2025

Nature Plants

Volume: 11, P: 743-760

The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang

Reviews02 Jul 2025

Nature

Volume: 643, P: 47-59

Extreme-ultraviolet spatiotemporal vortices via high harmonic generation

The generation of spatiotemporal optical vortices in the extreme-ultraviolet regime is demonstrated via high harmonic generation. Topologically coupled at the nanometre and attosecond domains, these light beams are attractive for exploring electronic dynamics in magnetic materials, chiral media and nanostructures.

Rodrigo Martín-Hernández
Guan Gui
Carlos Hernández-García

Research11 Jun 2025

Nature Photonics

P: 1-8

A mixed-methods study on negative psychological states of infertile women undergoing assisted reproductive treatment

Jia-Yu Hu
Yi-Dan Wu
Yu Zhang

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-14

Nuclear m⁶A modification regulates satellite transcription and chromosome segregation

Profiling nuclear N⁶-methyladenosine (m⁶A) modifications revealed enrichment of m⁶A on nuclear RNAs derived from chromosome pericentromeric γ satellite DNA II (GSATII), which regulates GSATII transcription and influences chromosome segregation during mitosis.

Chenyang Huang
Xiao Shu
Jianzhao Liu

Research22 May 2025

Nature Chemical Biology

P: 1-13

Effect of Thymectomy on Transplantation Resistance induced by Polyoma Tumour Homografts

R. C. TING

Research27 Aug 1966

Nature

Volume: 211, P: 1000-1001

Correlation of fibrinogen levels with acute myocardial infarction risk in the Chinese Han population

Jian-Ping Xu
Yang He
Yong-Ming He

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-10

Post-oxidation of all-organic electrocatalysts to promote O−O coupling in water oxidation

Metal-free catalysts offer a sustainable option for water oxidation but typically underperform compared to metal-based ones. Here, the authors report an all-organic catalyst that uses a rare oxide pathway to achieve high efficiency and long-term stability, comparable to metal-based systems.

Chun-Ting He
Li-Hong Yu
Xiao-Ming Chen

ResearchOpen Access12 May 2025

Nature Communications

Volume: 16, P: 1-11

Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Congmin Zhu
Linwei Wu
Jizhong Zhou

ResearchOpen Access29 Apr 2025

Nature Communications

Volume: 16, P: 1-14

International partnership for governing generative artificial intelligence models in medicine

Jasmine Chiat Ling Ong
Yilin Ning
Nan Liu

Correspondence30 Jun 2025

Nature Medicine

P: 1-4

Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial

As presented at the 2025 ASCO Annual Meeting, intracerebroventricular infusion of bivalent CAR T cells targeting EGFR and IL-13Rα2 in patients with multifocal, recurrent glioblastoma was feasible and well tolerated, with the maximum tolerated dose identified, one patient with a partial response and one patient with durable stable disease.

Stephen J. Bagley
Arati S. Desai
Donald M. O’Rourke

Research01 Jun 2025

Nature Medicine

P: 1-10

A foundation model for generalizable cancer diagnosis and survival prediction from histopathological images

Yang et al. developed a new method, BEPH, a foundation model trained on TCGA WSI images. BEPH improves cancer recognition, classification, and survival prediction across subtypes, potentially reducing reliance on expert annotations.

Zhaochang Yang
Ting Wei
Zhangsheng Yu

ResearchOpen Access10 Mar 2025

Nature Communications

Volume: 16, P: 1-16

The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by rapid motor neuron (MN) degeneration, with unclear causes in sporadic cases. Here, the authors showed that N6-methyladenosine (m6A) RNA modification drives ALS, and restoring it may protect MNs and lessen motor issues.

Ya-Ping Yen
Ting-Hsiang Lung
Jun-An Chen

ResearchOpen Access30 Apr 2025

Nature Communications

Volume: 16, P: 1-23

RNA Dependent DNA Polymerase of Human Acute Leukaemic Cells

ROBERT C. GALLO
STRINGNER S. YANG
ROBERT C. TING

Research05 Dec 1970

Nature

Volume: 228, P: 927-929

Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis

Guoqiang Wang
Xuan Ye
Hui Xiao

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-16

NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT

Liaoliao Zhu
Ting Zhao
Yang Song

ResearchOpen Access17 Jun 2025

Oncogenesis

Volume: 14, P: 1-12

Printed document layout analysis and optical character recognition system based on deep learning

Dong-Lin Li
Shih-Kai Lee
Yin-Ting Liu

ResearchOpen Access03 Jul 2025

Scientific Reports

Volume: 15, P: 1-15

CF₂H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines

The difluoromethyl group is a crucial fluorinated moiety, and the synthesis of chiral CF₂H-containing analogs is a powerful strategy in drug design and screening. Here, the authors report a strategy for the asymmetric construction of carbon stereocenters featuring a difluoromethyl group via nickel-catalyzed Negishi cross-coupling.

Peng Liu
Yan He
Xi-Sheng Wang

ResearchOpen Access11 Jan 2025

Nature Communications

Volume: 16, P: 1-8

Research on horizontal nonlinear sub-harmonic vibration characteristics and stability control of rolling mill roll system

Li Jiang
Ting Yang
Jiaquan Xie

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-17

Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement

CNS injuries cause persistent deficits. Here, the authors show that regenerated axons in an optic tract injury model form functional synapses, restoring the pupillary light reflex, and highlight neuronal types and presynaptic activity in recovery.

Xin Zhang
Chao Yang
Kai Liu

ResearchOpen Access04 Mar 2025

Nature Communications

Volume: 16, P: 1-20

Polymer effects on microjet impact and cavitation erosion

R. Y. TING

Research12 Aug 1976

Nature

Volume: 262, P: 572-573

Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C

Adipose-secreted SERPINA3C in exercised dams protects their offspring from high-fat diet-induced metabolic disorders by promoting KLF4-mediated anti-inflammatory effects in adipose tissue.

Yang Li
Ruo-Ying Li
Liang Guo

Research31 Jan 2025

Nature Metabolism

Volume: 7, P: 401-420

Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis

Ting Cheng
He-Yi Zhang
Sheng-Xiao Zhang

ResearchOpen Access02 Jul 2025

Scientific Reports

Volume: 15, P: 1-11

The construction of HMME-PDT efficacy prediction model for port-wine stain based on machine learning algorithms

Hongxia Yan
Yixin Tan
Xiangning Qiu

ResearchOpen Access02 Jul 2025

Scientific Reports

Volume: 15, P: 1-13

Preparation of an exogenous additive from Psoralea corylifolia fruit and its flavor-modifying effects on cigar tobacco leaves

Tianxiao Li
Dayuan Zhang
Xianghua Zeng

ResearchOpen Access02 Jul 2025

Scientific Reports

Volume: 15, P: 1-16

Assessment of iris vasculature in type 2 diabetes mellitus patients without diabetic retinopathy using anterior segment optical coherence tomography angiography

Yue Zhou
Ting Wang
Xiaoyu Zhu

ResearchOpen Access30 May 2025

Scientific Reports

Volume: 15, P: 1-8

Benchmarking large language models for biomedical natural language processing applications and recommendations

Baseline performance, benchmarks, and guidance for LLMs in biomedicine are limited. The authors assess four LLMs on 12 tasks, establish baselines, examine hallucinations, and provide recommendations for optimal LLM use.

Qingyu Chen
Yan Hu
Hua Xu

ResearchOpen Access06 Apr 2025

Nature Communications

Volume: 16, P: 1-16

Correction: Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition

Pu-Ting Dong
Mengdi Yang
Xuesong He

Amendments and CorrectionsOpen Access25 Jun 2025

International Journal of Oral Science

Volume: 17, P: 1

E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21

Chen-xing Jin
Ting-ze Feng
Ji-wei Liu

ResearchOpen Access01 Jul 2025

Scientific Reports

Volume: 15, P: 1-16

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

A common East Asian-specific defect of an alcohol metabolizing enzyme (ALDH2) causes glucose abnormality, obesity, and fatty liver. Here, the authors show an ALDH2 activator can treat these metabolic disorders in mice.

Yi-Cheng Chang
Hsiao-Lin Lee
Lee-Ming Chuang

ResearchOpen Access25 Sept 2023

Nature Communications

Volume: 14, P: 1-16

Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1

Zhi-Bin Ke
Jia-Yin Chen
Ning Xu

ResearchOpen Access23 May 2025

Cell Death & Disease

Volume: 16, P: 1-19

Legionella effector LnaB is a phosphoryl-AMPylase that impairs phosphosignalling

An effector protein called LnaB from Legionella pneumophila catalyses a unique type of AMPylation, and LnaB and its homologues represent a distinct family of AMPylases with specific structural features.

Ting Wang
Xiaonan Song
Yongqun Zhu

Research22 May 2024

Nature

Volume: 631, P: 393-401

Long-range transport of 2D excitons with acoustic waves

Excitons in 2D semiconductors suffer from a weak response to in-plane electric fields, inhibiting their transport beyond the diffusion length. Here, the authors demonstrate the directional, long-range transport of interlayer excitons in bilayer WSe₂ driven by the propagating potential traps induced by surface acoustic waves.

Ruoming Peng
Adina Ripin
Mo Li

ResearchOpen Access14 Mar 2022

Nature Communications

Volume: 13, P: 1-7

EGFRvIII-positive glioblastoma contributes to immune escape and malignant progression via the c-Fos-MDK-LRP1 axis

Feng Yuan
Yingshuai Wang
Hongwei Cheng

ResearchOpen Access17 Jun 2025

Cell Death & Disease

Volume: 16, P: 1-16

Genetically encoding ε-N-methacryllysine into proteins in live cells

It is challenging to purify and prepare large amount of methacrylated proteins from cells. Here, the authors develop genetic code expansion technology to site-specifically incorporate ε-N-Methacryllysine into proteins and identify the post-translational modification ε-N-methyl-ε-N-methacrylation.

Tian-Yi Zhu
Shi-Yi Chen
Bing Yang

ResearchOpen Access17 Mar 2025

Nature Communications

Volume: 16, P: 1-13

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial

Ting and colleagues report the safety and efficacy of combined radiation and immunotherapy in a phase II trial on patients with MSS colorectal or pancreatic cancer and observe that disease control correlates with higher repetitive RNA transcription.

Aparna R. Parikh
Annamaria Szabolcs
Theodore S. Hong

Research18 Nov 2021

Nature Cancer

Volume: 2, P: 1124-1135

Connectome-driven neural inventory of a complete visual system

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Aljoscha Nern
Frank Loesche
Michael B. Reiser

ResearchOpen Access26 Mar 2025

Nature

Volume: 641, P: 1225-1237

Metallaphotocatalytic triple couplings for modular synthesis of elaborate N-trifluoroalkyl anilines

The trifluoromethyl group can confer advantageous properties to biologically relevant molecules, but methods for its incorporation into aliphatic carbons that are more embedded within the core of the structure are less available. Here, the authors present a multicomponent coupling to synthesize carbon skeletons with a branched trifluoromethyl group via iridium metallaphotoredox catalysis.

Ting Zhou
Zhong-Wei Zhang
Chi Wai Cheung

ResearchOpen Access15 Nov 2024

Nature Communications

Volume: 15, P: 1-13

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

In this work, the authors present novel PLpro inhibitors, with lead compound GZNL-P36 showing potent activity against SARS-CoV-2 variants, improving survival and reducing lung viral loads in a mouse model, offering promise for COVID−19 therapies.

Yongzhi Lu
Qi Yang
Jinsai Shang

ResearchOpen Access23 Nov 2024

Nature Communications

Volume: 15, P: 1-16

Layer-edge device of two-dimensional hybrid perovskites

The edge of the thin sheets of two dimensional organic-inorganic hybrid perovskite crystals shows exotic physical properties that remain unexplored. Here Cheng et al. make electronic devices and study their transport properties, photoresponses and humid sensitivities which show large anisotropy.

Bin Cheng
Ting-You Li
Jr-Hau He

ResearchOpen Access05 Dec 2018

Nature Communications

Volume: 9, P: 1-7

Identification of a Fusobacterial RNA-binding protein involved in host small RNA-mediated growth inhibition

Pu-Ting Dong
Mengdi Yang
Xuesong He

ResearchOpen Access11 Jun 2025

International Journal of Oral Science

Volume: 17, P: 1-13

Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma

Linyu Yang
Qiang Qiu
Ting Niu

ResearchOpen Access23 Jun 2025

Signal Transduction and Targeted Therapy

Volume: 10, P: 1-14

MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition

Proteolytic targeting chimera (PROTAC) methodology is promising for cancer therapy but limited by the insufficient distribution and accumulation in most tumors. Here the authors assemble Ce6 and mitochondrial-targeting peptide into PROTAC agent dBET6 to achieve enhanced accumulation in tumor cells and subsequent BRD4 degradation, apoptosis induction thereby elicit its anti-cancer treatment.

Fan Tong
Yufan Wang
Huile Gao

ResearchOpen Access29 Nov 2024

Nature Communications

Volume: 15, P: 1-20

Observation of anomalously large Nernst effects in conducting polymers

The Nernst effect of transverse thermoelectric flow is usually small in less ordered systems with low charge mobility. Here, the authors show that conjugated polymers defy this expectation with Nernst effects orders of magnitude larger than predicted.

Yingqiao Ma
Xinglong Ren
Daoben Zhu

ResearchOpen Access07 Feb 2025

Nature Communications

Volume: 16, P: 1-10

ETV7 limits the antiviral and antitumor efficacy of CD8⁺ T cells by diverting their fate toward exhaustion

Jiang and colleagues identify ETV7 as a transcriptional node that skews CD8⁺ T cell transcriptional profiles toward exhaustion, consequently limiting antiviral and antitumor efficacy, and show that it can be targeted in CAR T cells to enhance efficacy.

Jie Cheng
Yifeng Xiao
Peng Jiang

Research13 Jan 2025

Nature Cancer

Volume: 6, P: 338-356

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling

Lu et al. perform systematic functional analyses using data from the TRACERx cohort of patients with non-small-cell lung cancer and delineate how FAT1 regulates homologous recombination repair, chromosomal instability and whole-genome doubling with distinct mechanisms.

Wei-Ting Lu
Lykourgos-Panagiotis Zalmas
Charles Swanton

ResearchOpen Access30 Dec 2024

Nature Cell Biology

Volume: 27, P: 154-168

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