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Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

This manuscript evaluates forecasts of laboratory-confirmed influenza hospital admissions, a new target for influenza forecasting in the United States. Across two influenza seasons, the FluSight ensemble is robust compared to submitted models.

Berberine has lipid-lowering effects and other metabolic benefits, but it presents with poor bioavailability. Here the authors conjugate berberine to liver-targeting nanoparticles, and show increased accumulation of berberine in the liver, improved metabolic profiles and reduced atherosclerotic plaques in mice.

Dipterocarp trees are iconic but severely threatened species in Asian rainforests. This study assembles high-quality genomes of seven dipterocarp species to reveal the molecular basis of key adaptations and identifies a recent sharp population decline coinciding with local human activity.

Follicle-stimulating hormone (FSH) is involved in mammalian reproduction, but several studies have suggested a role of FSH and its receptor in extragonadal tissue. Here, the authors show that FSH orchestrates glucose-stimulated insulin secretion (GSIS) via its receptor on pancreatic β-cells, with pre-menopausal FSH levels dose-dependently promoting GSIS and postmenopausal FSH levels inhibiting this effect.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Using complementary cryo-electron microscopy and functional studies, the authors demonstrate that botulinum neurotoxins exploit the accompanying nontoxic bacterial proteins, OrfXs and P47, activated by host digestive proteases, to greatly enhance their oral toxicity.

Different approaches have been described for the transdermal delivery of drugs. Here the authors report the design of a fluorocarbon modified chitosan-based non-invasive transdermal platform for the delivery of biomacromolecules, such as viral antigens for vaccines or immune checkpoint inhibitors for melanoma immunotherapy.

In a randomized phase 2 trial comparing anti-PD-1 plus anti-VEGF plus an HDAC inhibitor versus anti-PD-1 plus an HDAC inhibitor in patients with MSS/pMMR colorectal cancer, the triplet combination led to significantly better 18-week progression-free survival.

During plant development, organ size is controlled by cell proliferation and expansion, but the molecular mechanisms involved are unclear. Here, Lu et al.show that leaf cell expansion is controlled by the KUA1 transcription factor that acts in a circadian manner and modulates the expression of genes encoding cell wall-localized peroxidases.

An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that berberine can promote insulin secretion in healthy men in a phase 1 clinical trial.

Cellulose is synthesized by cellulose synthase complexes (CSCs), which are trafficked and delivered from the Golgi apparatus to the plasma membrane. Here Liu et al. reveal a non-canonical route for CSCs exiting from the Golgi.

Deuterodeamination, analogous to hydrodeamination, presents greater difficulties due to its frequently slower deuteration rate, interference by hydrogenation and constraints in deuterated sources. Here, the authors report a reliable, robust and scalable hydro- and deuterodeamination method capable of handling various primary amines.

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.

Ancient DNA, stable isotopes and other archaeological methods establish that humans were living at extremely high elevation on the Tibetan Plateau 4,400 years ago, maintaining sedentary lifestyles that combined fishing, hunting and crop exchange.

Natal downs adapted for heat conservation transition to juvenile feathers that support simple flight during bird development. Here the authors characterize gene expression networks and epigenetic changes and use functional perturbations to characterize evolutionarily conserved regulatory switches that control this transition in birds.

Electrically powered solitons in out-of-equilibrium nematics face challenges due to their random generation and uncontrollable motion. The authors present a reconfigurable optoelectronic approach using multi-strategy digital light projection, which allows precise control over the soliton’s entire lifecycle, enabling tailored generation, velocity modulation, directional transformation, and on demand trajectory.

Ligand discovery against membrane proteins has been a major challenge, mainly due to the peculiar nature of their natural habitat. Here, the authors designed a new chemical proteomic probe that targets the lysines exposed on the cell surface and developed a chemical proteomic strategy for global analysis of surface functionality in living cells.

Genomic, transcriptomic and DNA methylation data from tissue samples from 208 Chinese patients with prostate cancer define the landscape of alterations in this population, and comparison with data from Western cohorts suggests that the disease may stratify into different molecular subtypes.

Energy density and cyclability are often a trade-off for lithium-ion batteries. The authors develop cobalt- and nickel-free cathodes with both good cycling stability and high energy density through the integration of polyanion units into rocksalt structures.

Repetto et al. provide an analysis of the genetic basis of variation of neuro-related protein levels in plasma and link this to human behaviour and disorders.

Direct, site-specific methods of protein functionalization are of interest, but challenging due to difficulty in chemically differentiating a single site within a large protein. Here, the authors develop a Copper Assisted Sequence-specific conjugation Tag (CAST) method to achieve rapid, site-specific protein backbone chemical modification with pinpoint accuracy, and prepare various on-demand modified recombinant proteins using CAST.

Plant-beneficial bacteria provide multiple benefits to plants. This study constructs a database to couple microbial taxonomy with their plant-beneficial traits, and predicts that fossil-fuel-dependent scenarios could potentially lead to a marked decline of plant-beneficial bacteria abundance in global soils.

In this paper, the E3 ubiquitin ligase IPI7 is found to fine-tune the transactivation activity of IPA1 through non-hydrolyzed K29-ubiquitination chain, thereby timely regulating rice disease resistance during Magnaporthe oryzae infection.

Human serum albumin (HSA) can be used as a drug delivery material for cancer therapy. Here, the authors report an HSA-based photothermal platform that improves drug loading and photothermal therapeutic performance in breast cancer mouse models.

Phytopathogenic fungi threaten global food security but their global diversity and biogeography are underexplored. Using more than 20,000 globally distributed samples, this study builds a global atlas of phytopathogenic fungi, and predicts that that their diversity and invasion potential will increase globally by the end of this century, especially in forest and cropland ecosystems.

DNA methylation data of whole blood from Han Chinese individuals are used to map mQTLs, finding that cis- and trans-mQTLs show distinct patterns of East Asians (EA) ancestry-specific colocalization with complex trait variation.

It has been challenging to perform super-resolution imaging in large volumes due to aberrations encountered. Here, the authors combine single-wavelength Bessel lightsheet localization microscopy with tissue clearing techniques and image neurons across the whole brain of adult fruit flies.

A Bessel vortex modulated metalens is used for wide-band, multiple-order radial differential operations by presetting the order of the corresponding Bessel vortex. This enables synchronous spatial differential operations, with applications in optical data processing, machine vision and bio-imaging.

The mechanisms of stalled fork degradation in BRCA1/2-deficient cells remain unclear. UFL1, an UFM1-specific E3 ligase, was found to catalyze PTIP UFMylation at lysine 148, promoting stalled fork degradation by the MRE11 nuclease.

Faecal metagenomes and machine learning reveal a panel of 31 multikingdom microbiome markers and microbiome functions that are associated with autism spectrum disorder in male and female children.

DNMT3A-nucleosome interaction underpins the genomic DNA methylation landscape. Here, the authors investigate how an N-terminal fragment of DNMT3A recognizes the H2AK119ub1-marked nucleosome, providing insights into the chromatin-targeting mechanism of DNMT3A.

Here, the authors show a causal role for gut bacteria-derived metabolites tryptamine and phenethylamine in contributing to insulin resistance and the development of metabolic syndrome in patients with irritable bowel syndrome and type 2 diabetes.

Exercise and diet interventions are treatments for nonalcoholic fatty liver disease (NAFLD). Here the authors report that in randomized, controlled trial in patients with NAFLD exercise and diet intervention were associated with diversified gut microbiome keystone taxa. Exploratory analysis suggests gut microbial network may be used to predict the individual liver fat response to exercise intervention, if validated in future studies.

The complex and diverse molecular architectures along with broad biological activities of ent-kauranoids natural products attract increasing interest from synthetic chemists. Herein, the authors report the enantioselective total syntheses of C-19 oxygenated enmein-type ent-kauranoids, including (–)-macrocalyxoformins A and B and (–)-ludongnin C.

An effector protein called LnaB from Legionella pneumophila catalyses a unique type of AMPylation, and LnaB and its homologues represent a distinct family of AMPylases with specific structural features.

Uplift of the Gangdese arc in the southern Tibetan Plateau occurred independently of the India-Asia collision and was driven instead by lower crustal foundering, according to a geodynamic model developed with machine learning.

Producing vigorous seeds that can germinate and establish seedlings is vital for plant propagation. Here, the authors report the critical function of histone variant H3.3 in establishing chromatin accessibility and seed vigour in Arabidopsis.

2D Weyl semimetals are spin-polarized analogues of graphene that promise access to various topological properties of matter. Here, the authors evidence spin-polarized Weyl cones, Weyl nodes, and Fermi strings in monolayer bismuthene.

Here the authors measure viral load in samples from skin lesions, saliva, oropharynx, and rectum of 77 patients with acute monkeypox virus infection as well as from environmental fomite swabs and show a high seropositivity rate for antibodies against A29L and H3L.

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

Here, we present TP-DB; a pattern-based search engine based on 1.67 million helices from the Protein Database (PDB). We demonstrate the utility of TP-DB in identifying microbe-specific antigens, as well as the design of antimicrobial peptides and Protein-protein interaction blockers.