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Spin-waves have a variety of advantages for information processing, and here, Chen, Xu and coauthors demonstrate the deterministic switching of antiferromagnetic spin textures using non-linear spin-waves. The switching process is progressive, mirroring weighted sum operations in neuromorphic computing.

This study presents an ultradeep analysis of the N-glycoproteome in mouse tissues, establishing the largest dataset to date. The resource enhances AI models for glycopeptide prediction, provides insights into tissue-specific glycosylation patterns, and reveals distinct pathological signatures in neurodegenerative diseases. To facilitate access to mouse and human N-glycoproteome, the authors establish a comprehensive database resource N-GlycoMiner.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

The mechanism of lipoprotein sorting to the bacterial cell surface is still unclear. Here, authors determine the crystal structures of paLptDE-LptM and apo-paLptDE, providing insights into how SLPs are transported to the cell surface via LptDE.

The regulation of perovskite crystallization is essential for achieving efficient solar cells. Here, authors introduce K₂SnO₃ to induce formation of KI and PbSnO₃ with an ABX₃ structure to enhance film uniformity, achieving efficiency of 28.81% for four-terminal all-perovskite tandem solar cells.

Intracellular copper concentration has been linked to cell proliferation. Here, the authors demonstrate that copper binding to both Cyclin-dependent kinase 1 (CDK1) and CCNB1 is essential for activating CDK1 and promoting the G2/M transition in the cell cycle.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Photocages are crucial for applications in bioimaging and controlled drug release, yet expanding their structural diversity remains a challenge. Here, the authors introduce a class of hydrazone-based photocages that release fluorescent aldehydes upon light exposure, enabling precise sub-organelle imaging and efficient light-controlled drug delivery, with significant implications for biomedical research.

The various binding models of the GH57 family amylopullulanase with its substrate reveal a dual catalytic mechanism for glycosidic bond cleavage and a broad substrate recognition capability.

Current brain-targeted delivery strategies using orthosteric sites of receptors is highly susceptible to cross-reactions limiting efficiency. Here, the authors report on the allosteric targeting of receptors to avoid this and demonstrate application in drug delivery across the blood brain barrier.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

O3-type sodium anion-redox cathodes show promise but are hard to synthesize due to unclear mechanisms. Here, authors elucidate the role of oxygen conditions, enabling O3-Na[Li_1/3Mn_2/3]O₂ synthesis and developing Ti-substituted with capacities >190 mAh·g^-1.

Due to high bond dissociation energies of C(sp2)–F bonds, using fluorinated compounds in C(sp2)–C(sp3) cross-coupling is difficult. Here the authors report a protocol for enantioselective C(sp2)–C(sp3) coupling of dienyl fluorides with aldimine esters, enabled by synergistic copper and palladium catalysis.

[n]Peri-acenes have attracted interest as promising candidates for nanoelectronics and spintronics but the synthesis of large (n > 4) [n]peri-acenes is extremely challenging due to their intrinsic open-shell radical character and high reactivity. Herein, the authors report the synthesis and isolation of a derivative of peri-hexacene in crystalline form.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Macrophages play a key role in atherosclerosis through lipid uptake and inflammation. Here, the authors show that RNF128 promotes atherosclerosis by stabilizing scavenger receptor B1 (SRB1) via polyubiquitination, enhancing foam cell formation and inflammation, while its ablation reduces plaque formation in hyperlipidemic mice.

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

Determining glioma types directly from whole-slide images (WSIs) would be of great diagnostic utility. Here, the authors develop a deep learning model to identify diffuse glioma types from WSIs according to the 2021 WHO classification across multiple cohorts and with interpretable features.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles, but the role of ER-phagy in viral replication process remains poorly understood. Here, the authors show Zika virus targets key ER-phagy receptor to inhibit ER-phagy process and physiologically elucidate the basic mechanisms and viral pathogenicity by regulating ER-phagy.

Xu, Yu, Zhang, Ma, He and colleagues show that SHP-1 inhibition causes increased glycolysis and oxidative phosphorylation through PFKP in leukaemia stem cells, thereby promoting immunosurveillance and chemosensitivity in acute myeloid leukaemia.

Untargeted metabolomics reveals that 11,12-epoxyeicosatrienoic acid released from macrophages via gasdermin G pores has a key role in promoting fibroblast growth factor-dependent muscle regeneration following injury.

Mitochondrial DNA or retrotransposon cDNA released into the cytoplasm is degraded to prevent sterile inflammation. In this study, the authors demonstrate that nucleolytic degradation of these DNA species in a yeast model organism prevents their transfer to the nucleus and genome instability.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

A cereal-specific transcription factor, ZmICE1a, positively regulates storage in the central part of the endosperm while negatively regulating defence in its peripheral region, revealing the molecular mechanism underlying the antagonism between resistance and yield, which is crucial for cereal crop improvement.

An efficient molecular nanojunction photocatalyst for hydrogen evolution is identified from a combinatorial molecular library, assisted by a materials acceleration platform, which is then scaled-up to the litre scale using flow synthesis.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Potassium channels and membrane potential may influence macrophage function during inflammation. Here the authors show that the Kir2.1 potassium channel affects macrophage metabolism by altering cell surface retention of nutrient transporters and subsequently regulates inflammatory disease responses.

A multimodal model for the stratification of breast cancer risk based on clinical metadata, mammography and trimodal ultrasound images performed as well as or better than radiologists at tumour classification and at differential diagnosis.

A proteogenomic profiling analysis of single cells from the blood and lymph nodes of individuals living with HIV-1 reveals that CD4⁺ memory T cells harbouring intact provirus show signatures associated with resistance to immune-mediated killing and cell survival.

Nanosizing covalent organic frameworks using surfactants provides greatly improved water dispersibility and light-harvesting properties, leading to dramatically enhanced photocatalytic hydrogen production performance. Here the authors observe a reverse concentration-dependent photocatalytic phenomeno, whereby a higher photocatalytic activity is found at a lower catalyst concentration.

Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to be involved in autoimmunity but it is not clear how it functions in psoriasis. Here the authors show that CaMK4 is increased in psoriasis and promotes inflammatory responses in mouse models of psoriasis mediated through macrophages and keratinocytes.

Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients.

Despite essential roles in adult nervous systems, how heteromeric Cys-loop receptors work is unclear in the absence of an open state structure. Here, the authors report closed/open state structures and functional experiments, detailing an asymmetric gating mechanism driven by differing contributions from each subunit type.

Life is homochiral, and prior work posited that D-RNA may interact preferentially with L-amino acids. Here, the authors show that self-aminoacylating D-RNAs do not have an intrinsic preference for L-amino acids, suggesting that either handedness could emerge from early living systems.

Inspired by the idea of mimicking virus entry to host cells and macrophage-mediated virus clearance, the authors developed a lysosomal “TRAP”, which could efficiently capture, internalize, and degrade viruses and variants.

Orzya meridionalis is a wild rice species that has reproductive isolation with Asian cultivated rice. Here, the authors report the cloning of the second locus controlling hybrid male sterility between the two species and show the encoded toxin-antidote system provides stacked reproductive isolation for maintaining species identity.

Chloroplasts are ancient prokaryotes that divide by constriction of a ring-like division machinery. Structural determination of the intermembrane region of the ARC6–PDV2 complex helps to understand the coordination between inner and outer rings.