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Developing streamlined methods that can offer highly branched chiral allylamine products from simple alkene substrates is an important goal within organic chemistry. Here, the authors use a sterically adaptable chiral N-heterocyclic-carbene/Ni(II) catalyst system to overcome some of the limitations associated with this class of reactions.

Triboelectric nanogenerators can harvest mechanical energy from the environment to power sensors. Here, the authors use a low-resistance shunt to cut off the impedance coupling between the triboelectric nanogenerator and sensors, achieving accurate multi-mode sensing.

ELD1, a CCHC-type zinc finger protein, is found to modulate alternative splicing of the core oscillator gene OsCCA1 and thereby regulate photoperiodic flowering in rice. This reveals additional links between light signaling and the circadian clock.

A machine learning force-field framework is proposed to predict the density, viscosity and ionic conductivity of liquid electrolytes with accuracy that is higher than classical force fields.

In two-dimensional semiconductors, light can generate spin polarisations, however this effect is typically limited to low temperatures. By combining Lead Iodide (PbI₂) with transition metal dichalcogenides (TMDCs), the authors demonstrate room temperature light induced near-unity spin polarisations.

The realization and control many-body quantum states in perovskites would extend their application to ultrafast quantum operation. Here, the authors generate a cooperative quantum state of excitons in a lead halide perovskite quantum dot ensemble and control the ultrafast radiation through optical microcavites.

Targeting Ceramide Transfer Protein (CERT) is known to sensitize solid cancer cells to chemotherapy. Here this groups reports targeting CERT can effectively inhibit the growth and promote apoptosis of acute myeloid leukemia cells carrying FLT3-ITD mutation.’

Aromatic compounds can be prepared via dehydrogenation of cyclic compounds. Here the authors report the dehydroaromatization of endocyclic and exocyclic olefins via chain-walking isomerization and transfer-dehydrogenation catalyzed by palladium N-heterocyclic carbene complexes in the presence of alkenes as sacrificial reagents.

Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.

The concept of neuromorphic completeness and a system hierarchy for neuromorphic computing are presented, which could improve programming-language portability, hardware completeness and compilation feasibility of brain-inspired computing systems

Optical gyromagnetic properties are not observed in natural or metamaterials to date. Here, the authors experimentally demonstrated optical gyromagnetic properties in a magneto-plasmonic metamaterial, realizing the long-sought bi-gyrotropic medium.

Methods for the wireless, continuous monitoring and analysis of activities directly from the throat skin have not been developed. Here, the authors present a stretchable device platform that provides wireless measurements and machine learning-based analysis of vibrations and muscle electrical activities from the throat.

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

It is still challenging to make accurate diagnosis of biliary atresia (BA) with sonographic gallbladder images particularly in rural areas without relevant expertise. Here, the authors develop a diagnostic deep learning model which favourable performance in comparison with human experts in multi-center external validation.

Genome-scale genetic screens identify the small RNA-binding protein La as a strong mediator of prime editing.

Although strategies for the automated assembly of compounds of pharmaceutical relevance is a growing field of research, the synthesis of small-molecule pharmacophores remains a predominantly manual process. Now, an automated six-step synthesis of prexasertib is achieved by multistep solid-phase chemistry in a continuous-flow fashion using a chemical recipe file that enables automated scaffold modification through both early and late-stage diversification.

Hu et al. study the role of hexokinase 2 in microglial metabolism and function, and show its dual role under physiological and pathological conditions in a mouse model of stroke-induced neuroinflammation

This study unravels an important daytime Cl₂ source in the extra-polar atmosphere and shows that photolysis of particle nitrate at high acidity produced unprecedented levels of Cl₂, boosting the oxidative power and air pollutants like O₃.

The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotypes.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

GTSE1 performs oncogenic functions in various tumors; however, its role in clear cell renal cell carcinoma (ccRCC) remains unknown. Here, the authors found that GTSE1 is overexpressed in ccRCC, and its high expression was positively relation with advanced clinical stages and worse prognosis. In additional, GTSE1 knockdown inhibited ccRCC cell malignant phenotype in vitro and vivo. Mechanistically, GTSE1 promotes ccRCC malignance progression by attenuating KLF4 expression.

Wang et al. report on the role of a novel E3 ubiquitin ligase, Plastid Protein Sensing RING E3 ligase 1 (PPSR1), during tomato fruit ripening and find that it interacts with phytoene synthase 1 (PSY1) precursor protein and mediates its degradation via ubiquitination. This affects the steady-state level of PSY1 protein, the key rate-limiting enzyme in the carotenoid biosynthetic pathway. This study may provide a strategy for developing carotenoid-enriched horticultural crops.