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This study reveals that the varying responses of plant biomass to phosphorus addition across plant functional groups align with the leaf economics spectrum, with plants characterized by more acquisitive traits exhibiting stronger responses to phosphorus addition.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

Microwave-assisted tumour-derived microparticles enhance antitumour activity, safety and drug delivery, outperforming traditional ultraviolet-derived methods.

Emerging applications of steam electrolysis and electrochemical synthesis for future hydrogen technologies at intermediate temperatures set stringent requirements on the stability of protonic ceramic cells. Now a sintering approach enables densified Ce-free protonic zirconate cells with enhanced Faradaic efficiency and exceptional stability under harsh operating conditions.

Currently, intestinal ischemia/reperfusion injury lacks ideal diagnostic markers and effective therapeutic targets. Here, the authors show exosomal circEZH2_005 is an intestinal injury biomarker and protects the intestine from ischemia/reperfusion injury by promoting crypt cell proliferation via affecting hnRNPA1- mediated Gprc5a stability.

Colorectal cancer patients with mismatch repair-deficient, but not MMR-proficient tend to benefit from immune checkpoint blockade therapy. Here, the authors identify interactions among tumor and immune cells that are associated with the responsiveness to immunotherapy in colorectal cancer.

One effector of wheat disease pathogen is found to prevent the entry of thioredoxin into chloroplast. This disrupts the thioredoxin-mediated monomerization of STAYGREEN, a key regulator of senescence, and thereby suppresses plant defense responses.

Development of synthetic load bearing materials is important, but it can be challenging to achieve all the required properties. Here, the authors report the development of an organohydrogel from biobased materials, with favourable compressive strength and toughness.

Glucocorticoids and glucocorticoid receptor (GR) signalling can suppress anti-tumour immunity. Here the authors show that GR activates PD-L1 expression and represses MHC-I expression in pancreatic cancer cells, while GR inhibition enhances anti-tumour immunity and sensitises the cancer cells to immunotherapy.

Single-molecule techniques can shed light on biochemical dynamics with high precision, but they require a significant photon number per frame and are hampered by the limited number of photons emitted by each fluorophore before photobleaching. Here, the authors introduce MUFFLE, a deep-learning denoising tool that enables single-molecule FRET with up to 10-fold reduction in photon requirement per frame.

roX (RNA on the X) are crucial for male development in Drosophila. Here, the authors propose a role for roX RNAs in regulating gene expression at specific autosomal loci, working in coordination with Polycomb repressive complexes (PRCs).

The development of methods for conversion and utilization of amides has attracted much attention in organic synthesis and drug discovery. Herein, the authors report a divergent alkynylative difunctionalization of amides in a single transformation to generate either amines or alcohols through C–O or C–N cleavage.

The regulation of oncogenic protein sulfiredoxin-1 (SRX) remains to be understood. Here the authors show that SRX is targeted for ubiquitination and degradation by Keap1, the substrate-specific adaptor of the Cullin3 RING E3 ubiquitin ligase complex. Inactivation of Keap1 leads to accumulation of SRX and progression of colorectal cancer.

The nucleosome is one of the hallmarks of eukaryotes, a dynamic platform that supports many critical functions in eukaryotic cells. Here, the authors engineer the in vivo assembly of the nucleosome core in E. coli, forming nucleosome arrays that have profiles resembling those in eukaryotic cells, and are viable to have sustained growth under a condition for moderate histones expression.

Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize pluripotency.

Excessive inflammatory responses contribute to severe malaria. Here, Du et al, show that the protein tyrosine phosphatase PRL2 contributes to neutrophil activation and extracellular trap release in an experimental model of severe malaria.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

The SEED study is a phase 3 clinical trial demonstrating a beneficial effect on glycemic control of dorzagliatin, a glucokinase activator, in drug-naive patients with newly diagnosed type 2 diabetes.

Wheat E3 ubiquitin ligase TaPIR1-mediated ubiquitination and degradation of an atypical transcription factor TaHRP1 alters PhANGs expression to disrupt chloroplast function and ROS accumulation, increasing plant susceptibility to wheat stripe rust.

Setaria pan-genome constructed using genome assemblies of 110 representative accessions and variation analyses provides insights into foxtail millet domestication and the genetic basis for crop improvement.

Polo-like kinase 3 (Plk3) has a tumor suppressive role through the induction of apoptosis, however, the mechanism underlying its activation is unclear. Here, in pancreatic cancer, the authors show that activation of Plk3 is dependent on its cleavage into p41Plk3, by the metalloendopeptidase nardilysin.

Transposable elements (TEs) fulfill essential but poorly understood roles in genome organization and gene expression control. Here the authors show that the regulation of TEs occurs through overlapping epigenetic mechanisms that control the expression and chromatin signatures at TEs.

To understand the anomalous electronic transport properties of ZrTe₅ remains an elusive puzzle. Here, Zhang et al. report direct electronic evidence to the origin of the resistivity anomaly and temperature induced Lifshitz transition in ZrTe₅, indicating it being a weak topological insulator.

Zhuang et al. demonstrate that suppression of NCoR/SMRT enhances OSKM reprogramming efficiency, and that the barrier mechanism depends on the recruitment of HDAC3 to pluripotency loci by c-MYC.

While Ru-based electrocatalysts are among the most active for acidic water oxidation, they suffer from severe deactivation. Now, Yuen Wu, Wei-Xue Li and co-workers report a core–shell Ru₁–Pt₃Cu catalyst with surface-dispersed Ru atoms for a highly active and stable oxygen evolution reaction in acid electrolyte.

High-resolution structures of mammalian prions have remained elusive. Here, Manka et al. report the cryo-EM structure of infectious RML prion fibrils from mice. Structural similarity with recently reported infectious 263K prion fibrils from hamsters now suggests a common prion architecture.

Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.

The interplay between fungal pathogens and the innate immune system remains incompletely understood. Here, Wang et al. show that a small protein secreted by Candida albicans induces a TLR2- and TLR4-mediated inflammatory response in a mouse infection model.

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

The development of selective ClpP activators targeting only the MRSA isolates without interfering with the human variant is currently challenging. Here, the authors report on the structure-based design of enantiomers of ZG197 and identify the discriminator factor between the proteins.

TRPCs, nonselective cation channels, are involved in cardiac contraction and conduction. Here, the authors show that Trpc1/6 deficiency or pharmacological inhibition improves endotoxemic cardiac dysfunction and prolongs survival by prominently suppressing cardiac inflammation and ER Ca²⁺ release.