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The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Crop scientist whose high-yield hybrid rice fed billions.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The study of isotopes away from the beta stability valley is crucial for the understanding of nuclear structure, especially for neutron-deficient heavy nuclei. Here, the authors report the observation of the alpha-decay isotope 210-protactinium (Pa), extending the alpha-decay systematics of underexplored regions of the nuclides chart.

Multiple resonance (MR) emitters with narrowband luminescence typically suffer from inadequate frontier molecular orbital levels. Here, authors incorporate cyano motifs at peripheral sites of the MR backbone to adjust the energy levels, realizing device efficiency of over 23% for stable devices.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

In situ mechanical testing and simulations unveil a reversible shuffle twinning mechanism enabled by bond switching, which gives rise to anisotropic tensile superelasticity in GeSe ceramics.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Lilies are perennial plants with ornamental flowers and large genomes. The authors assemble genomes of two Liliales species, analyze lily phylogeny, flower and stem development (bulbs in lilies, rhizomes in flame lilies), bulb growth transitions, and colchicine biosynthesis.

The clinical significance of inferring cell spatial profiles from histology images from cancer patients remains to be explored. Here, the authors develop a weakly-supervised deep-learning method, HistoCell, for the direct prediction of super-resolution cell spatial profiles from histology images at the single-nucleus-level.

The underlying mechanism of lithium dendrite penetration through ceramic electrolytes is debated. Here, authors employ MD simulations to enable atomic-scale investigation in the process of dendrite penetration and the concurrent development of cracks during solid state lithium battery operation.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

On-surface synthesis of two-dimensional polymers is a useful strategy for designing the lattice, orbital and spin symmetries of materials, but controlling their layer stacking remains challenging. Now, a method to synthesize bilayer two-dimensional covalent organic frameworks at a liquid–substrate interface through monomer condensation has been developed; large-area moiré superlattices emerge from the twisted bilayer stacking.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The interfaces between ferromagnets and superconductors receive many attentions due to emergent relativistic spin-orbit coupling. Here, the authors provide possible evidence for spin triplet Andreev reflection at the interface between a van der Waals ferromagnet Fe_0.29TaS₂ and a s-wave superconductor NbN.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Fibers derived from non-silk proteins hold potential for various biomedical applications, but mechanically-balanced and highly-biocompatible regenerated protein fibers are elusive. Here, the authors report an entanglement-reinforced strategy to fabricate keratin/albumin bio-fibers that show high strength and toughness, along with favorable biocompatibility, degradability and immunocompatibility.

Wang et al. develop data-independent acquisition activity-based protein profiling, a quantitative chemoproteomic method to globally profile protein dopamination in the mouse brain, and identify a protective role of dopamine in regulating the function of microtubule-associated protein Tau.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

In two cohorts of patients with glioblastoma who received anti-PD-1, Sonabend and colleagues show that ERK1/2 phosphorylation, detected by immunohistochemistry, provides a biomarker for MAPK/ERK pathway activity and better survival on this therapy.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Ferroelectric field-effect transistors based on molybdenum disulfide can be used to build an in-memory sparsity architecture in which index memory is moved next to individual synapses, creating a sparse neural network without external memory indexing.

A diffusion-mediated synthesis strategy for organic–inorganic hybrid perovskite nanocrystals is reported, which can substantially slow down the reaction kinetics, improving size uniformity and achieving near-unity photoluminescence quantum yield.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Quantum teleportation has found important applications in quantum technologies, but pushing it to macroscopic objects is challenging because of the fragility of quantum states. Here, the authors demonstrate teleportation of states from light beams to the vibrational states of a macroscopic diamond sample.

Multiferroic BiFeO₃ is promising for applications where electric and magnetic fields need to be coupled, for example, in magnetic data storage. Here, combining theory and experiment the authors provide a microscopic insight into the switching of magnetization by electric fields in BiFeO₃.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Lattice stability related to the structural response is the basis for understanding mechanical and physical behavior of crystalline solids. Here, the authors show a manifestation of elastic instability in high-entropy alloys via elastic strain induced amorphization.

Hydrogen-doping driven metal to ferroelectric phase transition in a complex oxide NdNiO₃ is demonstrated. Transient negative differential capacitance and implementation of polarization decay into neural network for learning are then presented.