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Rosmarinol quinone (RQ) induces β-catenin phase separation, suppressing Wnt/β-catenin signaling and tumorigenesis. Abroquinone (albumin–RQ complex) was developed for targeted delivery and improved biosafety.

Land plants diverged from streptophyte algae around 460 million years ago. Marine Charophyceae fossils from the Upper Ordovician confirm that morphological innovations key to the evolution of terrestrial flora predate the emergence of land plants.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Enantioselective C—C activation remains heavily underexplored and has been predominantly limited to intramolecular reactions. Here the authors report two categories of asymmetric intermolecular [4+2] annulations between benzocyclobutenones and unsaturated reagents, namely, alkynes and cyclic dicarbonyl compounds.

In plants and algae, isoamylases drive phytoglycogen-to-amylopectin conversion. Here, the authors show that ISA1 and ISA2 form a heterocomplex that coordinately trims glucan branches to promote starch granule formation, defining a key step in starch biosynthesis.

Structural vacancies in crystalline solids have potential in tuning optoelectronic properties. However, the random distribution of vacancies a problem when creating materials with completely reproducible functions. Here authors use vacancy engineering to improve electronic communication between cluster units in 3D orientationally ordered MOF crystals.

The coupling of ferroelectricity and magnetic order enables the tunability of material properties. Here, authors realize magnetic-field-enhanced ferroelectricity and electrical-field-controlled magneto-transport in non-magnetic moiré superlattices.

In a reverse-translational study followed by a clinical trial, the targeting of antigen-presenting mast cells was identified as a therapeutic approach to overcome anti-PD-1 resistance in patients with metastatic triple-negative breast cancer who experienced clinical benefit when treated with the mast cell stabilizer cromolyn.

RNAi therapies have potential to treat a range of diseases including liver fibrosis. Here, the authors report on the delivery of miR-325-3p in nucleic acid spheres, which can enter the liver sinusoidal endothelial cells, reversing their capillarisation, treating liver fibrosis in mice.

Electrolyzers operating efficiently at industrial current densities offer promise but face challenges for practical NO_x⁻ -to-ammonia conversion. Here, the authors report a full runner electrolyzer stack that enhances mass transfer in porous electrodes for NO_x⁻ reduction at high current densities.

Electroreduction of low-concentration NO₃⁻ to NH₃ is limited by NO₃⁻ mass transfer. Here, the authors propose a strategy for NO₃ ⁻ enrichment through charge rearrangement within the inner Helmholtz plane, achieving near-unity conversion of NO₃⁻ to NH₃.

Authors introduce an unsupervised framework for automatic modulation recognition. By using multi-___domain signal representation and contrastive learning, it extracts high-quality features from unlabelled data, outperforming existing methods and reducing the need for labelled samples in wireless communications.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The tissue-specific accumulation patterns of pathogenic mtDNA mutations during aging remain incompletely understood. In this study, the researchers developed three mouse models with distinct mitochondrial tRNA mutations, revealing age-dependent accumulation of these mutations in the kidneys, leading to mitochondrial kidney disease.

Acinetobacter baumannii is an opportunistic pathogen that causes nosocomial and community-acquired infections. Here, the authors determine that human neutrophil α-defensin HNP1 can promote A. baumannii biofilm formation.

Effectiveness of existing H5N1 vaccines against circulating influenza strains remains largely unknow. Here, the authors test neutralization activity of sera from individuals vaccinated with an inactivated H5N1 vaccine against 17 pseudoviruses and suggest that high vaccine-induced antibody level likely provide cross-protection against circulating H5N1 strains.

Nonreciprocal transmission of waves is crucial for transport and redistribution of energy, yet the architecture to break time-reversal symmetry is hard to realise. Here, the authors proposed elastic-wave circulator that could achieve this without breaking reciprocity, enabling mode transition and wave trapping concurrently.

Phytophthora secretes a conserved trypsin-like serine protease, PsTry1, that suppresses apoplastic immunity by cleaving the extracellular ___domain of the co-receptor BAK1, revealing a novel mechanism by which pathogens overcome apoplastic immune defences.

A strategy for engineering photon-avalanche nanoparticles is proposed such that they exhibit an unprecedentedly strong nonlinear optical response and their emissions scale by more than 500th power of the pump intensity.

The authors make local heterogeneous dipolar structures in PbHfO3-based antiferroelectric ceramics, which exhibit a recoverable energy density of 20.04 J cm⁻³ accompany with an efficiency of 90.5%.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

The introduction of sodium heparin passivates interface defects and enhances bonding between the electron transport layer and the perovskite layer in perovskite solar cells. The best-performing devices exhibit a certified PCE of 26.54% and maintain almost 95% of their initial performance after 1,800 h of maximum power point tracking.

Global aging emphasizes the exploration of frailty and depression in relation to incident CVD in middle-aged and older adults. Here, the authors show that frailty is associated with increased CVD risk, partially through depression, with the association influenced by frailty transitions and stronger in males, the elderly, and those with unhealthy lifestyles.

This study presents an optical cloud computing system that enables long-distance, high-speed AI processing and communication with low power consumption. The approach offers a scalable and secure alternative to electronic cloud computing, addressing key energy and privacy challenges.

The full exploitation of back contact silicon solar cells is crucial to achieve a high performance for potential industrialization. Here, authors incorporate a double-sided light management strategy to reduce optical losses, achieving a total-area efficiency of 27.03% for 350 cm2 solar cells.

Model simulations suggest that cropland expansion since industrialization has reduced atmospheric biogenic secondary organic aerosol by 10% and its associated radiative cooling effect by 11%.

Extending the endurance of mushroom-type phase change memory remains challenging. Here, the authors design a nano-confined cell with an embedded heater, achieving a 1000 × improvement and attributing failure to carbon-induced collapse of the switching volume.

TUG protein localizes to the endoplasmic reticulum-Golgi intermediate compartment, forms biomolecular condensates, and organizes and stabilizes these membranes to support their function in diverse secretory and degradative trafficking pathways.

A new asymmetric non-fullerene acceptor, P2EH-1V, is designed and synthesized for constructing devices demonstrating record-high efficiencies of 26.7% (certified at 26.4%) over an aperture area greater than 1 cm² in perovskite–organic tandem solar cells.

The authors achieve a high electrocaloric temperature change (ΔT = 3.9 K) in c-textured BaTiO₃-KNbO₃ ceramics via compositional tuning and grain orientation engineering. The ΔT variation remain within ±10% across 30–80 °C, demonstrating exceptional stability.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

ELD1, a CCHC-type zinc finger protein, is found to modulate alternative splicing of the core oscillator gene OsCCA1 and thereby regulate photoperiodic flowering in rice. This reveals additional links between light signaling and the circadian clock.

Asymmetric migratory cross-coupling reactions, which proceed with heteroatom-based group migration, are challenging. Now a nickel-catalysed coupling reaction of amino alcohol-derived sulfonates with a variety of carbon-based electrophiles is reported, enabled by a radical 1,2-amino migration process. Modified chiral Bilm ligands are the key factor in achieving high stereoselectivity and reactivity.

Training foundation models often requires a costly budget and excessive computational resources. In this study, a low-cost instruction learning framework is proposed that could enable the rapid adoption of visual-language pathology applications.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

Symmetry breaking in quantum many-body systems is pivotal for understanding phase transitions, yet its extension to mixed states remains underexplored. The authors introduce the Wightman correlator as a diagnostic tool, demonstrating its equivalence to the fidelity correlator in identifying strong-to-weak symmetry breaking, with implications for analyzing complex quantum phases.