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Perovskite manganites exhibit intriguing but poorly understood properties, including multiferroicity. Here, the authors synthesize a Ce₃Mn₈ cluster that structurally resembles a perovskite repeat unit, and use this molecular analogue to elucidate mechanisms driving bulk perovskite properties.

Realizing metasurfaces with reconfigurability, high efficiency, and control over phase and amplitude is a challenge. Here, Li et al. introduce a reprogrammable hologram based on a 1-bit coding metasurface, where the state of each unit cell of the coding metasurface can be switched electrically.

The feasibility of satellite-assisted quantum communication is demonstrated by a field test on the ground. To supress noise due to sunlight the wavelength of 1,550 nm is chosen, and spectrum and spatial filtering technology developed.

Realizing conversion between microwave and optical signals in free space is a challenge. Here, the authors propose and demonstrate a programmable metasurface that can achieve wireless microwave-laser interconversion for bidirectional air-water cross-media wireless communications.

The mechanisms underlying vascular smooth muscle cell reprogramming in abdominal aortic aneurism (AAA) remain unclear. Here they show that FAM3A, a metabolic cytokine, serves as a cell fate-shaping regulator of smooth muscle cells to protect against AAA formation.

Emulsion gels have several attributes desirable for biomedical applications including large-amount encapsulation and storage, but the preparation method is usually specific and complicated. Here, the authors report a simple method for fabricating bridged emulsion gels by employing a polymer to regulate the assembly of commercial silica nanoparticles at the water/oil interfaces.

Rose is one of the most popular ornamental plants with crucial ecological, cultural and economic value. Here, the authors generated a high-quality telomere-to-telomere genome for the ancestor of tea rose, as well as investigated the release rhythm and regulatory networks of the special tea scent.

Tigecycline is widely used to treat complex bacterial infections. Here, authors present cryo-EM structures of tigecycline-bound eukaryotic ribosomes, revealing how it also targets the human mitoribosome with distinct binding properties.

Quantum speed limits are fundamental constraints on the speed of quantum state evolution. Here, the authors observe the known maximal quantum speed limits for few and many-body states on a superconducting quantum processor and identify the minimal quantum speed limits, which are less common than maximal ones.

Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold selectivity for GluN2C/2D compared to GluN2A.

The authors report a Yin-Yang balance between α-Synuclein and β-Synuclein via regulating phase separation in physiological states and Parkinson’s disease. AI-designed peptides mitigate the symptoms and prolong the lifespan of C. elegans PD models.

Shi et al. show that neuregulin-4 derived from brown adipose tissue can reduce endothelial injury and inflammation and alleviate atherosclerosis in male mice, via Akt and nuclear factor-κB signaling

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

A study demonstrates that metabolic signalling and inflammatory cues associated with obesity selectively induce expression of PD-1 on tumour-associated macrophages to suppress anti-tumour immunity.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

Cuticular wax is crucial for plant development and environmental interaction. This study reveals the negative impact of nitrogen on cuticular wax via MdBT2–MdMYB106–MdCER2L1, thus uncovering a novel pathway for N-mediated wax biosynthesis in apple.

The genetic and epigenetic predisposition of bilateral Wilms tumour remains to be investigated. Here, the authors perform multiomics analysis and identify the predominant genetic and epigenetic events associated with bilateral Wilms tumour predisposition.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

Human RNA binding protein Musashi-1 binds various host transcripts as well as Zika virus RNA in neural progenitor cells. Here, Chen et al. characterise the interactions between Musashi-1 and its binding site using a combination of molecular and biophysical methods to shed light on its role in viral neurotropism.

Multiomics joint analyses based on a structural variant (SV) map from 16 genome assemblies and 2,105 resequenced accession genomes shed light on the regulatory effect of SVs on gene expression and trait variation in Brassica napus.

Accurate molecular representation of compounds is a fundamental challenge for drug discovery. Here, the authors present a molecular video-based foundation model pretrained on 120 million frames of 2 million molecular videos, and apply it to molecular targets and properties prediction.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

An antiferromagnetic diode effect was observed in a centrosymmetric crystal without directional charge separation. This effect could be used to create in-plane field-effect transistors and microwave-energy-harvesting devices.

Understanding if lasting immune responses can be induced by SARS-CoV-2 infection is important for controlling the COVID-19 pandemic. Here, the authors show, in a cohort of 25 patients, that IgG and T cell responses, as well as neutralising antibody, are still detectable against various SARS-CoV-2 proteins 3 months post-symptom onset, while IgM levels largely wane at this time.

Using gold nanorods and 3D-SPORT to track dynamin-induced fission in live cells, Cheng et al. show that endocytic vesicles undergo a rapid, large rotation before fission, which requires dynamin’s GTPase activity.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Moderate disorder can induce topologically nontrivial phases. Liu et al. report the experimental observations of the competition and interplay between Thouless pumping and disorder on a 41-qubit superconducting quantum processor.

Although methodologies to modify the cores of numerous heterocycles have recently been investigation, studies of deconstructive ring-openings of the pharmaceutically important pyrazole structure are scarce. Here, the authors present a methodology using iodine and heat to reformat substituted pyrazoles into fused tricyclic azaheterocyclic (pyrazolopyridopyridazin-6-one) scaffolds.

Effective surveillance of respiratory virus particles in air requires highly sensitive tools that can produce timely and accurate results. Here, the authors develop a device for detection of four respiratory viruses in air with high spatial viral resolution and test it in different settings.

China’s afforested forests have higher tree densities and slower aboveground carbon accumulation rates than naturally regenerated forests, but they currently store more carbon because of their larger covered areas, according to an analysis of national forest inventory and remote sensing data.

Predicting the properties of a molecule from its structure with high accuracy is a crucial problem in digital drug design. Instead of sequence features, Zeng and colleagues use an image representation of a large collection of bioactive molecules to pretrain a model that can be fine-tuned on specific property prediction tasks.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Cryo-EM structures covering full-length yeast Smc5/6 in three states and the accompanying mutagenesis data reveal multiple new structural and functional features of this unique SMC complex.

The cause of overactive bladder is largely unknown and there is currently no effective therapy. Gaoet al. show that a membrane protein Pirt controls bladder emptying by inhibiting the neuronal purinergic receptor P2X3 and that treatment with a small Pirt fragment prevents bladder overactivity in mice.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

How the position of conspecifics is represented in the brain is not fully understood. Here authors show that the position of conspecifics is represented relative to self-position in the hippocampus of female mice, which is modulated by context and identity and improved through learning.

Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.