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DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

A Leptotrichia buccalis Cas13a diagnostic platform can be used to cleave and detect small concentrations of viral and human DNA.

Shen et al. established a strategy to screen for mutants showing altered mitochondrial transmission in Cucumis and cloned a nuclear endonuclease gene (MTI1) that controls paternal versus biparental mitochondrial inheritance.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Sun, Fu, Zheng, Hong, Liu et al. generate a single-nucleus transcriptomic atlas of the primate cochlear aging, identifying an age-related decline in Slc35f1 and showing that silencing Slc35f1 in mice induces hair cell degeneration and auditory deficits.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

By engineering the eukaryotic-derived Fanzor2-ωRNA system, Wei, Gao, Pan, Li and Chen developed a compact genome editor enNlovFz2, which demonstrated efficient genome-editing activity in vitro and in vivo, with a broad target-adjacent motif scope.

Proton-coupled electron transfer reactions are key steps in electrocatalysis. Here the authors introduce a computational method to model such processes including nuclear quantum effects under a grand canonical constant electric potential.

Chromosome-scale genome assembly of a vegetable-type elite pea cultivar ZW1 and population analyses using resequencing data of 314 accessions provide insights into the genetic basis of Mendelian and other agronomic traits.

The precise control and transition between multiple stochiometric phases is challenging. Here, the authors grow and characterize four wafer-scale stoichiometric phases of a Pd-Te binary compound through a sequential multi-step nucleation process.

By using liquid metal electrodes and selectively doped self-healing materials, the authors make devices with high performance, modular assembly, and application potential in wearable electronics.

The mechanisms by which tillandsioids adapt to elevated aerial habitats remain largely unexplored. Here, the authors report their evolution and link life history, diversification, comparative genomic, and functional changes to processes underlying the unique biology of air plants.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

Closed pores govern sodium-ion storage performance of hard carbon negative electrodes. Here, authors link pore mouth size evolution of the closed pores to the solvation structure and propose design principles for optimizing both closed pores and intrinsic defects.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

In two independent studies, Song et al. and Jiang, Dalgarno et al. present computational frameworks, perturbation-response score and Mixscale, respectively, to determine individual cellular variation in response to perturbation.

A nanoscale printing method is developed to fabricate three-dimensional high-refractive index photonic crystals whose bandgap spans in the entire visible range.

Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome engineering.

Here, the authors report the direct growth of periodic arrays of 2D semiconductor ribbons by exploiting the step edges of high-miller-index Au facets, showing potential for 2D electronic devices. The synthesized ribbons could also be merged to obtain wafer-scale single-crystal monolayers.

Using cryogenic electron microscopy, Gao et al. uncovered how CFTRInh-172 inhibits CFTR function by binding in its pore and allosterically inhibiting its gating. Their findings could pave the way for structure-based drug design for the treatment of secretory diarrhea and polycystic kidney disease.

Developing flexible, portable fluidic components for soft systems is challenging due to reliance on rigid, bulky parts. The authors present flexible electro-hydraulic power chips, fabricated via 3D printing, achieving high output density and demonstrating versatile applications.

A synthetic approach is described, for efficiently converting non-van der Waals solids into two-dimensional van der Waals transition-metal chalcogenide layers with specific phases, enabling the high-throughput production of monolayers.

Ultrafast diffraction is fundamental in capturing the structural dynamics of molecules. Here, the authors establish a variant of quantum state tomography for arbitrary degrees of freedom to characterize the molecular quantum states, which will enable the reconstruction of a quantum molecular movie from diffraction data.

Ultrahigh electromechanical response is accomplished by inducing extreme structural instability from competing antiferroelectric and ferroelectric orders.

Skeletal editing has emerged as an appealing strategy for scaffold-hopping-based drug discovery, but the enantioselective single-atom skeletal editing of N-heteroarenes is challenging. Now, using trifluoromethyl N-triftosylhydrazones as carbene precursors, the enantiodivergent dearomative skeletal editing of indoles and pyrroles has been achieved through asymmetric carbon-atom insertion.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

Multiple sclerosis and some other neuroinflammatory diseases are associated with aberrant CD4⁺ T cell differentiation and regulatory T cell function. Here authors show that the E3 ubiquitin ligase RNF213 is central to both physiological and pathologic CD4⁺ T cell differentiation, and finetunes IFN-β responses in multiple sclerosis.

MnBi₂Te₄ and Bi₂Te₃ can form natural superlattices, where the MnBi₂Te₄ layers are separated by multiples of Bi₂Te₃. The combination of these two materials offers a potential platform for the interplay of tunable magnetism and topology. Here, the authors show that MnBi₄Te₇ and MnBi₆Te₁₀ display a complex magnetic ground state with coexisting ferromagnetic and antiferromagnetic domains.

Guo and colleagues characterize an intact Carnegie stage 7 human embryo at single-cell resolution in a spatially resolved manner.

A cryogenic electron microcopy study of structures of a human receptor for bitter taste finds that cholesterol can activate the receptor, while the tastant molecule acts allosterically on the receptor.

Peach is an economically important fruit crop. Here, the authors carry out a large-scale population genomics analysis of peach, describing its demographic history as well as genes associated with domestication and edibility traits.

Developed on cytology images of hydrothorax and ascites from 57,220 cases at four hospitals, a deep-learning model shows high accuracy in tumor origin prediction and presents prognostic value when patient treatment is consistent with the cancer origin predicted by the model.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

It is challenging to create efficient and compact neuromorphic sensory system based on nano-scale nonlinear dynamics. Yang et al. present a capacitance-coupled VO2 oscillatory network, which serves as a continuous-time dynamic system for sensory pre-processing, enabling tasks such as touch and gesture recognition.

The application of pressure effectively suppresses the spin–charge order in trilayer nickelate La₄Ni₃O_10−δ single crystals, leading to the emergence of superconductivity.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Short prokaryotic Argonaute and Sir2 proteins function as an antivirus system. Here the authors describe structures of SPARSA (a heterodimer of Sir2-APAZ and prokaryotic Argonaute) with and without template DNA and guide RNA, providing structural basis of its assembly and activation by the recognition of the invading virus.

A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo.

The authors of this manuscript identify that Gpr54 activation by its natural ligand Kisspeptin-10 can abrogate bone resorption. Mechanistically, Gpr54 recruits both active Src and the Dusp18 phosphatase, which causes Dusp18 to dephosphorylate Src at Tyr 416.