Nature Search

Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

Liang Chen
Mengjia Hong
Dali Li
Research03 Jun 2025
Nature Biotechnology

P: 1-12
A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes

A mitochondrial disease is modeled using engineered base editors in rats.

Liang Chen
Changming Luan
Dali Li
Research03 Jun 2025
Nature Biotechnology

P: 1-5
Chemical Decoding of Spatial Biology

The spatial organization of biomolecules helps orchestrate a range of biological processes; however, links between spatial organization and regulation of physiological and pathological processes can be difficult to unravel. The development of innovative tools and recently uncovered insights were discussed at the ‘Chemical Decoding of Spatial Biology’ symposium.

Ziqi Liu
Yan Zhang
Peng R. Chen
News & Views08 May 2025
Nature Chemical Biology

Volume: 21, P: 983-984
How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Jie Tang
Jing Zhang
Yue Wu
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1005-1022
In situ lysosomal proteomics enabled by bioorthogonal photocatalytic proximity labelling

In situ profiling of lysosomal proteomes is impeded by the acidic and digestive environment of lysosomes. Now, a bioorthogonal photocatalytic system (CAT-Lyso) is developed that is compatible with these conditions, enabling the proximity labelling of lysosomal proteomes within living cells.

Yan Zhang
Ziqi Liu
Xinyuan Fan
Research13 Feb 2025
Nature Catalysis

Volume: 8, P: 162-177
Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Qiang Xu
Su Lui
Yue Wu
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 676-687
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen
Mengjia Hong
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Boron neutron capture therapy (BNCT) is a type of radiotherapy that induces cell damage through a localized nuclear reaction. Here the authors describe the design of a carborane-based covalent organic framework as a boron capsule loaded with immune adjuvants for concurrent BNCT and immunotherapy, promoting anti-tumour immune responses in preclinical cancer models.

Yaxin Shi
Zhibin Guo
Zhibo Liu
ResearchOpen Access05 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

Nam-Shik Kim
Zhexing Wen
Guo-li Ming
ResearchOpen Access03 Mar 2021
Nature Communications

Volume: 12, P: 1-11
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Dysregulation of mTOR signalling is a converging mechanism in lissencephaly

Cellular, transcriptomic and proteomic analyses of organoids derived from human induced pluripotent stem cells show that mTOR pathway hypoactivation is involved in two genetically distinct lissencephaly spectrum disorders.

Ce Zhang
Dan Liang
Kaya Bilguvar
ResearchOpen Access01 Jan 2025
Nature

Volume: 638, P: 172-181
Bioorthogonal photocatalytic proximity labeling in primary living samples

Studying subcellular proteomes in primary living cells is crucial for understanding health and disease. Here, the authors introduce CAT-S, a non-genetic method based on photocatalysis, enabling in situ deciphering of mitochondrial proteomes in primary cells from mouse tissues and human blood.

Ziqi Liu
Fuhu Guo
Xinyuan Fan
ResearchOpen Access28 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Population sequencing enhances understanding of tea plant evolution

Tea is an important beverage crop with a large and heterozygous genome. Here, the authors assemble the genome of the cultivar Longjing 43 and conduct a population genetics study to reveal divergent selection for disease resistance and flavor between the two variety groups.

Xinchao Wang
Hu Feng
Yajun Yang
ResearchOpen Access07 Sept 2020
Nature Communications

Volume: 11, P: 1-10
Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Jilian Fu
Quan Zhang
Yue Wu
Research29 May 2024
Nature Genetics

Volume: 56, P: 1110-1120
Federated benchmarking of medical artificial intelligence with MedPerf

Federated learning can be used to train medical AI models on sensitive personal data while preserving important privacy properties; however, the sensitive nature of the data makes it difficult to evaluate approaches reproducibly on real data. The MedPerf project presented by Karargyris et al. provides the tools and infrastructure to distribute models to healthcare facilities, such that they can be trained and evaluated in realistic settings.

Alexandros Karargyris
Renato Umeton
Peter Mattson
ResearchOpen Access17 Jul 2023
Nature Machine Intelligence

Volume: 5, P: 799-810
Author Correction: Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

Nam-Shik Kim
Zhexing Wen
Guo-li Ming
Amendments and CorrectionsOpen Access30 Apr 2021
Nature Communications

Volume: 12, P: 1
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

A base editor for precise adenine transversions is demonstrated in mouse embryos.

Liang Chen
Mengjia Hong
Dali Li
Research15 Jun 2023
Nature Biotechnology

Volume: 42, P: 638-650
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Nana Liu
Longjiang Zhang
Yue Wu
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1126-1137
Author Correction: Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Yaxin Shi
Zhibin Guo
Zhibo Liu
Amendments and CorrectionsOpen Access04 Sept 2023
Nature Communications

Volume: 14, P: 1
Author Correction: Neural synchronization and its impact on intergroup attitudes in dynamic interactions

Yatian Lei
Siyuan Liu
Fangfang Wen
Amendments and CorrectionsOpen Access25 Mar 2025
Communications Biology

Volume: 8, P: 1
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.

Fei Li
Ming Han
Dong Gao
ResearchOpen Access08 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Functional genetic encoding of sulfotyrosine in mammalian cells

Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.

Xinyuan He
Yan Chen
Wei Niu
ResearchOpen Access24 Sept 2020
Nature Communications

Volume: 11, P: 1-10
Pre-oxidized ultramicroporous carbon cloth with ultrahigh volumetric capacity and ultralong lifespan for capacitive desalination

Xinyuan Zhao
Yongshuo Zheng
Wei Wen
ResearchOpen Access31 Oct 2023
npj Clean Water

Volume: 6, P: 1-8
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue

Electromagnetic devices involving a vibratory actuator and a soft strain-sensing sheet can dynamically measure the Young’s modulus of skin and of other soft biological tissues at depths of millimetres.

Enming Song
Zhaoqian Xie
John A. Rogers
Research27 May 2021
Nature Biomedical Engineering

Volume: 5, P: 759-771
Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines

2-Fluoroindoles are an important structural scaffold in many bioactive or therapeutic agents, but efficient constructions of 2-fluoroindole derivatives are very sparce. Here the authors report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity.

Jianke Su
Xinyuan Hu
Qiuling Song
ResearchOpen Access17 Aug 2021
Nature Communications

Volume: 12, P: 1-10
Synaptic dysregulation in a human iPS cell model of mental disorders

Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology of mental disorders; this approach was used with samples from a family with a schizophrenia pedigree and a DISC1 mutation, revealing synaptic abnormalities and large-scale transcriptional dysregulation.

Zhexing Wen
Ha Nam Nguyen
Guo-li Ming
Research17 Aug 2014
Nature

Volume: 515, P: 414-418
Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor

Photodynamic therapy has attracted interest in treating cancer but it is limited in hypoxic tumors due to a lack of oxygen. Here, the authors describe a nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer.

Shuting Xu
Xinyuan Zhu
Deyue Yan
ResearchOpen Access24 May 2018
Nature Communications

Volume: 9, P: 1-9
Neural synchronization and its impact on intergroup attitudes in dynamic interactions

The influences of competition and cooperation on intergroup attitudes are underpinned by distinct neural processes, while the interaction sequence exerts a carryover effect

Yatian Lei
Siyuan Liu
Fangfang Wen
ResearchOpen Access26 Feb 2025
Communications Biology

Volume: 8, P: 1-11
Associations between soft drinks intake and primary dysmenorrhea among Chinese undergraduate female students

Lijiao Wang
Shuo Wen
Peng Lu
ResearchOpen Access11 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Fas signaling-mediated T_H9 cell differentiation favors bowel inflammation and antitumor functions

Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated T_H9 cell differentiation, while p38 activation by PKC-β antagonizes this effect, thereby supporting a synergy between p38 inhibitor and Fas for T_H9 differentiation.

Yingying Shen
Zhengbo Song
Jianli Wang
ResearchOpen Access02 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis

Hongyun Wang
Feizhou Li
Jun Yuan
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-22
Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders

Xinyuan Wang
Fei Ye
Guo-li Ming
Research23 Aug 2019
Molecular Psychiatry

Volume: 26, P: 1346-1360
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation

Xinyuan Li
Xiang Peng
Xin Gou
Research02 Aug 2023
Cell Death & Differentiation

Volume: 30, P: 2167-2186
Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma

Songsong Wang
Yan Li
Zhongmin Zhang
ResearchOpen Access25 May 2024
Scientific Reports

Volume: 14, P: 1-19
Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis

Yujia Fan
Xiaohan Huo
Huili Hu
ResearchOpen Access23 Feb 2022
Cell Death & Differentiation

Volume: 29, P: 1673-1688
Antibody-based binding ___domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

Zhao Chen
Changyou Lin
Runqiang Chen
ResearchOpen Access22 Jun 2023
Oncogenesis

Volume: 12, P: 1-12
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis

Guo Chen
Xinyuan Li
Yuanbin Jiang
ResearchOpen Access20 Mar 2024
Scientific Reports

Volume: 14, P: 1-16
No impact of transgenic cry1Ie maize on the diversity, abundance and composition of soil fauna in a 2-year field trial

Chunmiao Fan
Fengci Wu
Xinyuan Song
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis

Yuting Chen
Chenchen Guo
Hongbin Ji
CorrespondenceOpen Access04 Jun 2024
Cell Discovery

Volume: 10, P: 1-4
Engineered chimeric insecticidal crystalline protein improves resistance to lepidopteran insects in rice (Oryza sativa L.) and maize (Zea mays L.)

Yang Liu
Siping Han
Dongyun Hao
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Antibiotic resistance patterns in soils across the Scottish landscape

Elevated levels of metals, polychlorinated biphenyls, and selenium can lead to the increase of antimicrobial resistance gene richness and abundance in Scottish soils, according to a national-scale high-spatial resolution assessment.

Eulyn Pagaling
Rupert Hough
Charles W. Knapp
ResearchOpen Access01 Nov 2023
Communications Earth & Environment

Volume: 4, P: 1-13
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

Hongshuang Yu
Wanlin Yang
Min Jin
ResearchOpen Access16 Dec 2021
Cell Death & Disease

Volume: 13, P: 1-15
High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote

Haidi Chen
Jingwen Xue
Cheng Deng
ResearchOpen Access10 Feb 2022
Scientific Reports

Volume: 12, P: 1-14
Deciphering molecular details in the assembly of alpha-type carboxysome

Yilan Liu
Xinyuan He
Wei Niu
ResearchOpen Access10 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells

Jie Zhang
Jiefang Huang
Yanyun Zhang
ResearchOpen Access03 Jan 2020
Cellular & Molecular Immunology

Volume: 18, P: 1476-1488
Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS

Jifang Gao
Zhaoyu Qin
Shilian Liu
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Downregulation of TMEM220 promotes tumor progression in Hepatocellular Carcinoma

Ting Li
Lei Guan
Huqin Zhang
Research28 Jul 2021
Cancer Gene Therapy

Volume: 29, P: 835-844
The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation

Honghong Sun
Mei Lin
Youhai H. Chen
ResearchOpen Access20 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing

Hai-Jun Hu
Xiu Liang
Xin-Yuan Liu
ResearchOpen Access30 Nov 2020
Cell Death & Disease

Volume: 11, P: 1-21
Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model

Wen Lei
Hong-bin Liu
Yi-gang Wang
Research18 Mar 2013
Acta Pharmacologica Sinica

Volume: 34, P: 531-540

Search

Filter By:

Search

Quick links