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In this work, authors show that deletion of FprB enhances the antibacterial activity of gallium against Pseudomonas aeruginosa, revealing a combination strategy and demonstrating the utility of CRISPRi-seq for therapeutic target discovery.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

Patients with gastric cancer often present with poor performance status, limiting both quality of life but also treatment options as they are often excluded from clinical trials. Here, the authors report a phase II trial investigating anlotinib (multi-TKI) plus toripalimab (anti-PD-L1 monoclonal antibody) in treatment-naïve advanced gastric cancer patients with performance status 2.

C=O cleavage of formamides and full transfer of the resulting fragments into final products are highly appealing, particularly in multi-component reactions for the synthesis of structurally complex molecules. Now three-component reactions of diazo compounds with allylic substrates and formamides are presented, giving extensively reorganized products via multi-step relay.

Here, using samples from 146 mother-infant pairs and multi-omics, the authors characterize the dynamics of the gut microbiome, metabolome, and antibiotic resistance gene profiles during the first year of life in association with prenatal exposure to trace elements.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

(Hetero)aryl sulfoximines are useful bioisosteres of (hetero)aryl sulfones in medicinal chemistry as they have improved aqueous solubility and metabolic stability. Here, the authors report a synthesis of (hetero)aryl sulfoximines via copper-catalysed coupling of (hetero)aryl iodides and sulfenamides.

Although dry reforming of methane can convert CO₂ to valuable chemicals, the reaction requires near-equivalent amounts of CH₄. Now it has been demonstrated that an electro-thermocatalytic CH₄ reforming process, when combined with the reverse water–gas shift and H₂O electrolysis reactions, can efficiently catalyse CO₂-rich natural gas into syngas.

This study elucidates that d-galacturonic acid and d-glucuronic acid regulate apple fruit softening by repressing MdHb1 expression through the MdMYB2/MdNAC14/MdNTL9-MdHb1 regulatory module, offering new insights into postharvest fruit quality control.

The direct electro-reduction of diluted CO₂ in acidic media can circumvent CO₂ purification and reduce carbon loss. Here, the authors use an ionomer coating layer to enrich the diluted CO₂ and block proton transport, thereby achieving high carbon utilization in diluted CO₂ in an acidic electrolyte.

Understanding precise structures of two-/three- dimensional covalent organic polymers through single-crystal X-ray diffraction analysis is interesting however, to grow high-quality single crystals of these materials is challenging. Here, the authors incorporate tellurium into the backbones covalent organic polymers as a concise and fast method to grow large single crystals.

Clinical trials of CD47 blocking antibody in human cancer patients have not yielded ideal results. Here the authors show that USP2 stabilizes CD47 through deubiquitination, whereas USP2 inhibition enhances macrophage phagocytosis, reprograms tumor microenvironment and synergizes with anti-PD-1 treatment.

Electrostatic effects of separators under internal electric field is crucial for Li metal batteries. Here, authors develop a high dielectric constant fiber separator that shows substantial polarization under electric field to facilitate a robust and low-resistance solid-electrolyte interphase.

For electrochemical CO₂ reduction to CO, there exists a trade-off between selectivity and activity for noble metal catalysts. Here, authors report a Cu-based trimetallic catalyst that is selective to CO, challenging the monopoly of noble metals in CO₂-to-CO conversion.

The partial replacement of the A-site by divalent methylenediammonium cations inhibits ion migration and photoinduced halide segregation in wide-bandgap perovskites. Single-junction devices achieve a certified power conversion efficiency of 22.71%, whereas perovskite/Cu(In,Ga)Se₂ tandem devices exhibit an efficiency of 30.13% in a four-terminal architecture.

Metal-free catalysts offer a sustainable option for water oxidation but typically underperform compared to metal-based ones. Here, the authors report an all-organic catalyst that uses a rare oxide pathway to achieve high efficiency and long-term stability, comparable to metal-based systems.

Pan-genome analysis of 24 alfalfa accessions identifies key structural variations associated with salt tolerance and quality traits and provides resources for genomics-assisted breeding in alfalfa.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

The interplay between electronic topology and superconductivity is of great current interest in condensed matter physics. Here, the authors unveil an unconventional two-dimensional superconducting state accompanied by a van Hove singularity in the recently discovered Dirac nodal line semimetal ZrAs₂, which is exclusively confined to the top and bottom surfaces.

Non-invasive approaches for risk stratification and screening remain crucial for colorectal cancer (CRC). Here, the authors develop a model for CRC risk stratification by integrating plasma proteomics data with polygenic risk score and QCancer-15 risk score, which could guide recommendations for earlier screening of high-risk populations.

Recent advancements in biological technologies have enabled the measurement of spatially resolved multi-omics data. Here, the authors present COSMOS and demonstrate its superior performance compared to existing methods for integrating spatially resolved multi-omics data.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Enantioconvergent cross-electrophile coupling of non-redox-active alcohol derivatives is challenging. Now, taking advantage of Ni–C bond homolysis, enantioconvergent coupling of non-redox-active propargylic esters with chlorogermanes enables the synthesis of chiral propargyl germylation products.

The complete biosynthetic pathway of Prim-O-Glucosylcimifugin and 5-O-Methylvisamminoside in Saposhnikovia divaricata is resolved and their de novo biosynthesis is reconstructed in Nicotiana benthamiana leaves. The evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants is further analyzed.

Phylogenetic origin of the Y haplome present in allopolyploid Triticeae species is unclear. Here, the authors report the genome assembly of allohexaploid Elymus nutans, reveal the all likely combinations of St, Y, and H haplomes during the allopolyploid origins, and identify gene responsible for UV-B radiation adaptation.

Pancreatic ductal adenocarcinoma (PDAC) cells can utilise the tumour microenvironment to metastasise to the liver. Here the authors show that hepatoctyes overexpress SLIT2 to enable premetastatic niche formation for ROBO1-positive PDAC cells to support the survival of these tumour cells in the liver.

Tang, Yue, Xu and colleagues map the proteome of several thousand individuals over a 9-year period to identify potential biomarkers of ageing and of age-associated diseases.

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

Diatoms are crucial marine microorganisms, but the molecular mechanisms underlying their temperature tolerance remain unclear. This study identifies the heat shock transcription factor PtHSF2 as a key regulator of thermal tolerance and cell size plasticity in Phaeodactylum tricornutum, revealing its role in gene regulation and stress response.

In situ mechanical testing and simulations unveil a reversible shuffle twinning mechanism enabled by bond switching, which gives rise to anisotropic tensile superelasticity in GeSe ceramics.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.