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The development of vertical p-i-n junctions has been hindered by complex fabrication techniques and performance trade-off between responsivity and speed. Here, authors employ WSe₂ thin layers to construct photodiode, reporting responsivity of 0.388 A/W and response time down to sub-10 picoseconds.

This work introduces DeepTernary, a deep learning method for rapid and accurate prediction of PROTAC and molecular glue-induced ternary complex structures, achieving state-of-the-art results by learning from a curated dataset, TernaryDB.

In a reverse-translational study followed by a clinical trial, the targeting of antigen-presenting mast cells was identified as a therapeutic approach to overcome anti-PD-1 resistance in patients with metastatic triple-negative breast cancer who experienced clinical benefit when treated with the mast cell stabilizer cromolyn.

Chai et al. use cryo-electron microscopy to systematically interrogate the conformational landscape of motor protein dynein. The reported structures reveal intermediate states in the mechanochemical cycle of dynein, the role of adenosine triphosphate and the communication mechanism with microtubules.

In-sensor computing offers a promising solution for image processing with reduced data transfer. Here, the authors report programmable and multifunctional van der Waals optoelectronic sensors, showing their application for snapshot compression and recognition of dynamic videos and 3D spectral data.

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Human vesicular polyamine transporter underpins learning and memory formation by loading polyamines into secretory vesicles. Here, the authors decipher the transporter structure and suggest an antiport mechanism involving both direct and indirect competition between protons and polyamine.

Controlling phase transitions in MoOx semiconductors is challenging. Here, the authors develop a lab-on-device system to modulate proton intercalation, achieving conductance modulation and enabling electrochemical memory and neural network applications.

Neural crest cells differentiate into distinct fates during craniofacial morphogenesis, though how these are acquired remains unclear. Here they show that mesenchymal progenitors in the mouse maxilla are committed to specific fates before they arrive at their final anatomical locations.

The authors report the large low-field-driven electrocaloric effect in the novel organic-inorganic hybrid TMCM-CdCl₃, underlyingly from the disordering of organic cations and the low-symmetry interaction induced two-step meta-electric transition.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Liu et al. report the multi-site chelate effect using quercetin for Sn²⁺ and retarding crystallisation in FASnI₃-based optoelectronic synapse. 12 × 12 real-time NIR imaging array enables spatiotemporal information fusion for object recognition, enhancement, and motion perception in complex conditions.

The historically independent evolution of bioinspired and biointegrated vision is increasingly showing a trend of convergence. This Review discusses each technological framework emphasizing visual devices that mimic the structures of the natural eyes and the information-processing capabilities of biological visual systems.

To maintain the efficacy of drugs metabolized by CYP3A4, pan-CYP3A inhibitor is often co-administered, but the high homology between CYP3A4 and CYP3A5 has hampered the development of selective CYP3A4 inhibitors. Here, the authors report a series of selective CYP3A4 inhibitors and show that differential C-terminal loop conformations and two distinct ligand binding surfaces disfavour the binding of selective CYP3A4 inhibitors to CYP3A5.

Skyrmions, a type of topological spin texture, have garnered interest for use in spintronic devices. Typically, these devices necessitate moving the skyrmions via applied currents. Here, Yang et al demonstrate the driving of skyrmions by surface acoustic waves.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Based on an immunogenicity screen of monkeypox virus (MPXV) surface proteins, the authors develop an mRNA vaccine with 12 antigens, which they combine with T cell epitope-rich regions to achieve protection through coordinated activation of humoral and cellular immune responses.

Pan-genome analysis of 24 alfalfa accessions identifies key structural variations associated with salt tolerance and quality traits and provides resources for genomics-assisted breeding in alfalfa.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

Visual adaptive devices show promise for simplifying circuits and algorithms in machine vision systems. Here, the authors report a visual adaptive transistor with tunable avalanche effects and microsecond-level bionic vision capabilities, recognizing images in dim and bright conditions with over 98% accuracy.

Adult human hearts exhibit restricted regenerative ability, where cardiomyocyte loss leads to dysfunction, while neonatal hearts can regenerate, though the molecular mechanisms remain poorly understood. Here, the authors show that N-cadherin plays a crucial role in driving cardiomyocyte self-renewal by stabilizing β-catenin, representing a unique opportunity to promote cardiac regeneration and restore contractile function in the injured adult heart

Yang and colleagues have previously reported a clinically guided culture method to generate allogeneic CAR-NKT cells by engineering human hematopoietic stem and progenitor cells. As potential application, here the authors describe the design and characterization of allogeneic CD33-targeting CAR-NKT cells, showing anti-tumor activity in preclinical models of bone marrow-resident myeloid malignancies.

Retinitis pigmentosa (RP) is the most common type of inherited retinal dystrophy without effective treatments. Here, authors apply prime editing (PE) system to correct the point mutation in a preclinical RP mouse model. In vivo treatment achieves genome editing and restores mice vision.

Genomic analyses of Citrus species including haplotype-resolved genomes of Citrus sinensis and Citrus aurantium highlight the origin of sweet orange and provide a strategy for de novo domestication of perennial crops.

Chen et al. present a deep learning-based lead optimization model that combines generative artificial intelligence with structure-based approaches. The method is successfully applied to the design of drug-like molecules targeting the recently identified LTK protein target with high potency and selectivity.

In magnetic materials, geometry-defined competing interactions between spins combined with quantum fluctuations can present the possibility of quantum liquid states which do not order even as 0K is approached. Here, the authors present an analogue built from electric dipoles on a triangular lattice.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

A natural pathway in rice and in seven other major crop species degrades 57–89% of accumulated methylmercury and releases Hg into the air. The MeHg demethylation within rice mitigates Hg flux into human food webs, diminishing human cognitive damage and generating global economic benefits of US$30.7–84.2 billion.

Phase-switchable preparation of two-dimensional WS₂ is achieved through an electrochemical Li⁺ intercalation-based exfoliation strategy. A low discharge current density with high cutoff voltage produces pure semiconducting 2H phase WS₂ bilayers, while a higher discharge current density with a lower cutoff voltage favours semimetallic 1T′ phase WS₂ monolayers.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.