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Scientific Reports (17)
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Showing 1–50 of 59 results

Advanced filters: Author: Yaqing Chen Clear advanced filters

A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Mingqing Tang
Guoxing Ma
Ruian Xu
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

Human leucocyte antigens are important in the adaptive immune response. Here, the authors use data from the UK Biobank linked to electronic health records to investigate the association between genetic variation in HLA alleles and antibody responses to SARS-CoV-2 vaccination and breakthrough COVID-19 outcomes.

Junqing Xie
Beatriz Mothe
Daniel Prieto Alhambra
ResearchOpen Access13 May 2024
Nature Communications

Volume: 15, P: 1-11
Chanoclavine synthase operates by an NADPH-independent superoxide mechanism

The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.

Chun-Chi Chen
Zhi-Pu Yu
Shu-Shan Gao
ResearchOpen Access05 Mar 2025
Nature

Volume: 640, P: 840-846
Waving potential in graphene

Attempts have been made in flowing liquids over carbon nanomaterials to generate electric voltages, but a convincing or significant voltage is yet to be obtained. Here, Yin et al.show an electrokinetic process in which an electric potential of 0.1 V is generated in graphene by a moving liquid–gas boundary.

Jun Yin
Zhuhua Zhang
Wanlin Guo
Research06 May 2014
Nature Communications

Volume: 5, P: 1-6
Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases

Glia abnormalities drive the progression of demyelinating diseases. Here, the authors show that reactivated astrocytes secrete clusterin to impede remyelination by blocking astrocytic removal of myelin debris and oligodendrocyte precursor cell differentiation in mouse models of demyelination.

Chen Chen
Yaqing Shu
Wei Qiu
ResearchOpen Access06 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Multi-omics data are readily integrated using quartet reference materials.

Yuanting Zheng
Yaqing Liu
Leming Shi
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1133-1149
X-ray based radiomics machine learning models for predicting collapse of early-stage osteonecrosis of femoral head

Yaqing He
Yang Chen
Leilei Chen
ResearchOpen Access20 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
A real-world multi-center RNA-seq benchmarking study using the Quartet and MAQC reference materials

Here the authors report on an RNA-seq benchmarking study that demonstrates greater inter-lab variations in detecting subtle differential expression. The study reveals the impact of experimental execution, experimental designs, low-expression gene filtering, and analysis tool selection.

Duo Wang
Yaqing Liu
Rui Zhang
ResearchOpen Access22 Jul 2024
Nature Communications

Volume: 15, P: 1-21
Correction: Publisher Correction: Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Hongsheng Zhang
Eunchai Kang
Zhiheng Xu
Amendments and CorrectionsOpen Access18 Jul 2018
Nature Communications

Volume: 9, P: 1
Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

A new RNA reference set improves detection of differential expression in clinical settings.

Ying Yu
Wanwan Hou
Yuanting Zheng
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1118-1132
Releasing a sugar brake generates sweeter tomato without yield penalty

A study identifies two genes that act as brakes controlling the sugar content of tomatoes and demonstrates their manipulation to generate sweeter tomatoes without affecting the fruit size and yield.

Jinzhe Zhang
Hongjun Lyu
Sanwen Huang
ResearchOpen Access13 Nov 2024
Nature

Volume: 635, P: 647-656
Chemical composition and mixing state of elemental carbon-containing particles from solid fuel combustion

Yajing Kong
Qiyuan Wang
Junji Cao
ResearchOpen Access27 May 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-9
Multimodal GPT model for assisting thyroid nodule diagnosis and management

Jincao Yao
Yunpeng Wang
Dong Xu
ResearchOpen Access03 May 2025
npj Digital Medicine

Volume: 8, P: 1-15
Author Correction: Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

Ying Yu
Wanwan Hou
Yuanting Zheng
Amendments and CorrectionsOpen Access02 Oct 2023
Nature Biotechnology

Volume: 42, P: 1150
Author Correction: Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

Peng Wang
Lin Jin
Jianhua Qin
Amendments and Corrections31 Oct 2023
Nature Biomedical Engineering

Volume: 8, P: 1499
Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.

Hongsheng Zhang
Eunchai Kang
Zhiheng Xu
ResearchOpen Access01 Jun 2016
Nature Communications

Volume: 7, P: 1-11
Analysis of the prevalence characteristics and risk factors of pulmonary tuberculosis combined with extrapulmonary tuberculosis in elderly patients

Tianshui Niu
Yaqing Li
Fei He
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats

The sympathetic nervous system can contribute to the development of hypertension, but the neurogenic mechanisms involved are incompletely understood. Here the authors report that afferent nerves in the perirenal adipose tissue (PRAT) contribute to the maintenance of high blood pressure, and PRAT ablation, denervation or upregulation of calcitonin gene-related peptide reduce blood pressure in hypertensive rats.

Peng Li
Boxun Liu
Xiangqing Kong
ResearchOpen Access06 Jun 2022
Nature Communications

Volume: 13, P: 1-13
Unraveling the causal genes and transcriptomic determinants of human telomere length

Variation in human telomere length has been well studied, but most previous studies have used adult telomere length. Here, the authors explore the genetic basis of telomere length in the placenta and find suggestive causal genes modulating human telomere length.

Ying Chang
Yao Zhou
Dandan Huang
ResearchOpen Access21 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Transcriptomes shed light on transgenerational and developmental effects of ocean warming on embryos of the sea urchin Strongylocentrotus intermedius

Dongtao Shi
Chong Zhao
Yaqing Chang
ResearchOpen Access13 May 2020
Scientific Reports

Volume: 10, P: 1-7
Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors

Improving the imaging of cancer may enhance the treatment of patients, Here, the authors develop a Mn(II) based nanoparticle contrast agent for MRI imaging and show that the nanoparticles can cross the brain barrier and image glioma cells.

Ruixue Qin
Shi Li
Hongmin Chen
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Strong and high-conductivity hydrogels with all-polymer nanofibrous networks for applications as high-capacitance flexible electrodes

Huimin He
Yaqing Chen
Lizhi Xu
ResearchOpen Access09 Sept 2024
npj Flexible Electronics

Volume: 8, P: 1-11
Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

Integrated alveolus and blood–brain barrier tissue chips recapitulate neuropathogenesis associated with infection by SARS-CoV-2.

Peng Wang
Lin Jin
Jianhua Qin
Research22 Jun 2023
Nature Biomedical Engineering

Volume: 8, P: 1053-1068
Study on plasma metabolomics profiling of depression in Chinese community-dwelling older adults based on untargeted LC/GC‒MS

Jiangling Guo
Peipei Han
Qi Guo
ResearchOpen Access05 May 2024
Scientific Reports

Volume: 14, P: 1-15
Plasma biomarkers in patients with familial cavernous malformation and their first-degree relatives: a cross-sectional study

Chunwang Li
Shuna Huang
Fuxin Lin
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Mechano-regulated metal–organic framework nanofilm for ultrasensitive and anti-jamming strain sensing

High performance flexible strain sensors with accurate signal detection and noise screening are key to the development of smart sensing systems. Here, the authors demonstrate metal–organic framework based strain sensors that are ultrasensitive, robust, and non-responsive to environmental noise.

Liang Pan
Gang Liu
Run-Wei Li
ResearchOpen Access19 Sept 2018
Nature Communications

Volume: 9, P: 1-10
Atypical behaviour and connectivity in SHANK3-mutant macaques

The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.

Yang Zhou
Jitendra Sharma
Shihua Yang
Research12 Jun 2019
Nature

Volume: 570, P: 326-331
Individualized therapy guided by single-cell sequencing in anti-GABA_AR encephalitis

Yaqing Shu
Yu Huang
Wei Qiu
ResearchOpen Access08 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-8
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities

Shao and colleagues present a multiomic analysis of breast tumor samples from Chinese patients, consisting of genomic, transcriptomic, proteomic, metabolomic, radiomic and digital pathology data.

Yi-Zhou Jiang
Ding Ma
Zhi-Ming Shao
Research12 Feb 2024
Nature Cancer

Volume: 5, P: 673-690
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study

Ying Yu
Yuxi Li
Shuhua Yi
ResearchOpen Access12 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-8
Insulating phase at low temperature in ultrathin La_0.8Sr_0.2MnO₃ films

Yaqing Feng
Kui-juan Jin
Guozhen Yang
ResearchOpen Access01 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

A multivalent bi-specific nanoconjugate can promote immune cells to recognize and eradicate cancer cells in a receptor targeted manner, leading to the generation of potent and durable anti-tumour immunity.

Hengfeng Yuan
Wen Jiang
Betty Y. S. Kim
Research01 May 2017
Nature Nanotechnology

Volume: 12, P: 763-769
Identification of INHBA as a potential biomarker for gastric cancer through a comprehensive analysis

Fang Liu
Jiayi Liu
Lei Yang
ResearchOpen Access01 Aug 2023
Scientific Reports

Volume: 13, P: 1-23
Assembly and maintenance of phyllosphere microbial diversity during rubber tree leaf senescence

Leaf senescence has significant impacts on the composition, diversity, assembly, and functions of phyllosphere microbiomes, especially impacting endophytic bacterial communities.

Guoyu Lan
Yaqing Wei
Fangliang He
ResearchOpen Access27 Sept 2024
Communications Biology

Volume: 7, P: 1-12
Myeloid-derived itaconate suppresses cytotoxic CD8⁺ T cells and promotes tumour growth

Itaconate is a metabolite with immune-modulatory effects in myeloid cells. In this study, Zhao, Teng et al. report an additional role for itaconate in CD8⁺ T cells, with implications for immune surveillance and anti-tumour immunity.

Hongyun Zhao
Da Teng
Bin Zheng
Research14 Nov 2022
Nature Metabolism

Volume: 4, P: 1660-1673
Effects of the brown algae Sargassum horneri and Saccharina japonica on survival, growth and resistance of small sea urchins Strongylocentrotus intermedius

Fangyuan Hu
Mingfang Yang
Yaqing Chang
ResearchOpen Access27 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Low-dose arsenic trioxide inhibits pancreatic stellate cell activation via LOXL3 expression to enhance immunotherapy in pancreatic cancer

Yue Zhao
Yunlong Li
Yuzhou Huang
Research05 Nov 2024
British Journal of Cancer

Volume: 131, P: 1928-1941
Designing nanomedicine for immuno-oncology

Drawing from recent successes in cancer immunotherapy, this Perspective discusses that effective cancer-nanomedicine therapies can be designed to prime antitumour immunity far from the site of disease.

Wen Jiang
Christina A. von Roemeling
Betty Y. S. Kim
Reviews10 Feb 2017
Nature Biomedical Engineering

Volume: 1, P: 1-11
Time dynamics of COVID-19

Cody Carroll
Satarupa Bhattacharjee
Jane-Ling Wang
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-14
Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization

Li Zhang, Zhimin Cui, and Qianqian Li et al. compare the infectivity, host tropism, and antigenicity of 10 SARS-CoV-2 variants using a VSV-based pseudovirus system. Their results suggest that variants carrying E484K display the most significant reduction in sensitivity to neutralization, and may provide further insight into the development of relevant therapeutics for SARS-CoV-2 infection.

Li Zhang
Zhimin Cui
Youchun Wang
ResearchOpen Access13 Oct 2021
Communications Biology

Volume: 4, P: 1-10
Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model

Kangli Cui
Yaqing Wang
Jianhua Qin
ResearchOpen Access13 Jul 2020
Microsystems & Nanoengineering

Volume: 6, P: 1-14
Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis

Jing Wang
Jie Liu
Chunjian Li
ResearchOpen Access11 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Yaqing Qie
Hengfeng Yuan
Betty Y.S. Kim
ResearchOpen Access19 May 2016
Scientific Reports

Volume: 6, P: 1-11
Analysis of the factors influencing moderate to poor performance status in patients with cancer after chemotherapy: a cross-sectional study comparing three models

Ke Xi
Lin Jingping
Liu Dun
ResearchOpen Access09 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Actinomycetes-derived imine reductases with a preference towards bulky amine substrates

Imine reductases can catalyze reductive amination reactions to produce chiral amines, however, transformation of bulky amines has been challenging. Here, by using an increasing-molecule-volume-screening method, the authors identify a group of imine reductases that can accept bulky amines and achieve an efficient gram-scale synthesis of an API sensipar analogue.

Jun Zhang
Xin Li
Chengsen Cui
ResearchOpen Access08 Oct 2022
Communications Chemistry

Volume: 5, P: 1-9
Network evolution of regional brain volumes in young children reflects neurocognitive scores and mother’s education

Yidong Zhou
Hans-Georg Müller
Jane-Ling Wang
ResearchOpen Access20 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
Acclimatization of photosynthetic apparatus and antioxidant metabolism to excess soil cadmium in Buddleja spp.

Weichang Gong
Bruce L. Dunn
Yunmei Shen
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-10
HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer

Xingyue Weng
Hao Liu
Jianzhen Shan
ResearchOpen Access07 Jul 2022
Cell Death Discovery

Volume: 8, P: 1-10
Correction: Corrigendum: Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

Yaqing Qie
Hengfeng Yuan
Betty Y. S. Kim
Amendments and CorrectionsOpen Access01 Aug 2016
Scientific Reports

Volume: 6, P: 1
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

Peng Wang
Ronghua Luo
Jianhua Qin
ResearchOpen Access08 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-17

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