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Diabetic wounds are a prevalent type of chronic wound that is challenging to treat due to the dynamic and complex wound microenvironment. Here, Cong et al. presents a dimeric copper peptide incorporated hydrogel for multifunctional treatment of diabetic wounds.

Schizophrenia exhibits significant variability in brain structures, traditionally viewed as static due to heterogeneous subgroups. Here the authors use magnetic resonance imaging data from 1,792 individuals with schizophrenia to reveal that gray matter volume variability is greater in early stages and decreases over time, highlighting dynamic brain alterations with implications for understanding disease progression.

Rhombohedral-stacked (R-stacked) transition metal dichalcogenide bilayers exhibit remarkable properties, but their large-area epitaxial growth remains challenging. Here, the authors report the remote epitaxy of centimetre-scale single-crystal R-stacked WS₂ bilayer films on sapphire substrates.

Rapid detection of diverse biomarkers is crucial for public health. Here, the authors develop NAPTUNE, a versatile platform that identifies multiple nucleic acids and proteins targets within 45 minutes using a nuclease cascade.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Although the hetero-Diels–Alder reaction is a staple of organic chemistry, catalytic asymmetric versions of the inverse-electron demand variant often require specially engineered substrates for the reaction to work. Here the authors cyclize non-activated alkenes with α,β-unsaturated ketones or aldehydes to form chiral fused heterocycles using a chiral phosphoric acid catalyst.

Comprehensive molecular characterisations could shed light on the high heterogeneity and poor prognosis of gliomas. Here, the authors perform proteomic profiling of 188 glioma patients, revealing immune and metabolic neuron-related subgroups as well as metabolic biomarkers linked to prognosis.

Dysfunction in the hippocampal circuitry in individuals with first-episode schizophrenia and delusions is linked to deficits in behavioral pattern separation and recognition memory.

Tungsten trioxide (WO₃) is considered the most promising photocatalyst for the highly selective oxidation of methane to formaldehyde, though the origins of its catalytic activity and reaction mechanism are still debated. Here, the authors use WO₃ with {001} and {110} facets as model photocatalysts, demonstrating that the photocatalytic oxidation of methane to formaldehyde in WO₃ depends on the surface structure, leading to different formaldehyde selectivity.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Rice and potato plants are more productive after epitranscriptome engineering.

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Su, Chen et al. show that sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4/ROS/NLRP3/caspase 1 pathway, leading to the release of ox-mtDNA contributing to neutrophil extracellular traps (NET) formation. NET in turn release S100A8/A9 and accelerate platelet pyroptosis, forming a positive feedback loop, thereby amplifying the production of proinflammatory cytokines. GSDMD deficiency in platelets or pharmacological inhibition of S100A9 using Paquinimod can break this detrimental feedback loop, thus ameliorating excessive NET-mediated inflammation in mouse models of severe sepsis.

The polarization of distinct scaffold-signaling hubs at opposite cell poles constitutes the basis of asymmetric cell division. Here, the authors show that phase separation serves as a general mechanism to regulate the assembly and dynamics of a new-pole scaffold-signaling hub.

Zhang and colleagues found that Omicron RBD binding to Siglec-9 impaired phagocytosis and antigen presentation in macrophages, an effect abrogated by an F375S mutation in the spike protein of Omicron.

MISAR-seq combines spatial-ATAC-seq and RNA-seq for spatial profiling of both chromatin accessibility and gene expression, as demonstrated in the developing mouse brain.

Whole-exome sequencing analyses in a cohort of 1,030 patients with premature ovarian insufficiency identify new likely pathogenic variants and reveal distinct genetic architectures between primary and secondary amenorrhea.

MyoD is a transcription factor expressed in skeletal muscle that plays a critical role in determining myogenic cell fate. Here, Hu et al. reveal a metabolic role of MyoD in orchestrating systemic energy homeostasis by mediating muscle-fat crosstalk through the muscle-secreted lipokine DLPC.

Previous work suggested that histone demethylase JMJD3 is detrimental to somatic cell reprogramming. Here, the authors show that while JMJD3 has a context-independent detrimental effect on early stages of reprogramming, during late stages it activates epithelial and pluripotency genes together with Klf4.

Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.

Developing hybrid rice cultivars requires time consuming random crossing. Here, the authors develop a new next generation sequencing-based quantitative trait locus mapping method to dissect heterotic gene OsMADS1 and demonstrate the feasibility of pyramiding two genes to achieve large heterotic effect.

IL-17 mediated inflammation in the lung is mediated by different effector molecules. Here the authors show that the epigenetic regulator epithelial sirtuin 6 (Sirt6) is associated with lung inflammation in asthma patients and that Sirt6 contributes to promotion of inflammation in mouse asthma models.

Chen et al. report that the YTHDF family of m⁶A-RNA-binding proteins can be differentially regulated by the post-translational modification O-GlcNAcylation, leading to differential regulation of the YTHDF proteins on translation and phase separation.

A graph-theoretical programmable quantum photonic device composed of about 2,500 components is fabricated on a silicon substrate within a 12 mm × 15 mm footprint. It shows the generation, manipulation and certification of genuine multiphoton multidimensional entanglement, as well as the implementations of scattershot and Gaussian boson sampling.

Despite lung adenocarcinoma having a high global mortality, the genetic mutations present in Asian patients are uncharacterized. Here the authors use genomic and transcriptomic analysis to identify thirteen significantly affected genes, including RHPN2, GLI3, MRC2, TP53 and IQGAP3.

The critical temperature of single-layer FeSe films is much higher than the bulk of other iron-based superconductors, but the mechanism for this is unclear. Adding to the puzzle, Liu et al.show that it is much more difficult to induce superconductivity in a double-layer FeSe film than a single layer.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Gastrulation entails a series of events that are highly coordinated in space and time. Here they construct a spatiotemporal molecular atlas of lineage trajectories in the gastrulating mouse embryo by mapping single cells to spatial coordinates in the germ layers with reference to positional data in the transcriptome.

The conversion of methane to target one-carbon oxygenates relies on a two-step process that is carbon and energy intensive. Direct oxidation offers a sustainable alternative pathway. Here, the authors report on the selective photocatalytic oxidation of methane at room temperature using bismuth vanadate catalyst, realizing high methanol and formaldehyde selectivity.

Community-weighted mean foliar stable carbon isotope signatures are mainly affected by environmental factors in meadow and typical steppes, and by leaf traits in desert steppes, according to field measurements in three steppe types along a moisture gradient in Inner Mongolia.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.