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A sort-in-memory system that relies on digit reads on one-transistor–one-resistor memristor arrays can offer improved throughput, energy efficiency and area efficiency compared with conventional sorting systems.

Some rhizosphere microbes protect plants from phytopathogens through unclear molecular mechanisms. Here, Zhang et al. show that a rhizosphere bacterium displays antimicrobial activity against phytopathogenic fungi by reducing the activity of the fungal NatA acetyltransferase complex, thus inducing protein degradation and apoptosis.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

The heterogeneity of HSPCs in response to IR stress remains poorly characterized. Here, the authors provide insights into the molecular intricacies of IR-induced BM injury and reveal the roles of BMP4-BMPR2 signaling in radiation resistance of HSCs.

The effects of non-reacting components on polyatomic reactions are still largely unclear. Here, the authors show through a combined experimental and theoretical study of the D + CH₄ reaction that the CH₃ umbrella bending mode serves as a reporter mode, revealing how the D atom dynamically approaches CH₄.

Emerging in-memory computing using memristors promises better energy efficiency but often focuses on existing AI algorithms. Here, the authors report a distinct and computation-efficient AI algorithm based on memristor drift-diffusion kinetics for pattern classification, implemented on 180 nm memristor chips.

Electronic metal-support interaction within Pd/TiO₂ are optimized for photocatalytic H₂O₂ evolution and furfural oxidation to furoic acid, realizing the simultaneous utilization of photogenerated electrons and holes for dual value-added products.

Acetylation is a posttranscriptional modification widely distributed across RNA types. Here, the authors uncover the role of tRNA ac⁴C12 for translational efficiency and tRNA quality control in both normal and heat stress conditions in mammalian cells.

To push the boundary of sol-gel chemistry towards high quality organic membrane construction is challenging. Here, the authors show a controlled nanocrystal suturing strategy in sol-gel solutions to afford highly crystalline and free-standing covalent organic framework membranes.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Tao et al. study the role of TRMT6 in colorectal cancer, where it is upregulated and show that TRMT6 supports histone biosynthesis by stabilizing tRNA-Lys-TTT-1-1. Targeting TRMT6 reduced histone mRNA translation in a codon-biased manner.

The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Spin–orbit torques in a geometrically asymmetric device made from a perpendicularly magnetized ferromagnet can switch its magnetization without the assistance of an applied magnetic field.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

A deep-learning algorithm that removes patient-identifying information from facial images, while retaining sufficient information for accurate disease diagnosis, has the potential to protect patient privacy and facilitate public acceptance of facial imaging for use in digital medicine.

The phenol industry faces a pressing sustainability challenge from the production of acetone as a by-product at a level far beyond its market. Here the authors develop an electro-biosystem that can efficiently convert such surplus acetone into valuable long-chain commodity chemicals.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Land surface modelling suggests that preserving woody debris in managed forests could remove 769–937 GtCO₂ from the atmosphere between 2025 and 2100.

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

Cui et al. report analogue photoelectronic reservoir computing with IGZO synaptic transistors as the reservoir and TaOX-based memristor array as the output layer. A receptive field inspired encoding scheme is implemented to simplify the feature extraction for dynamic vision processing.

Polygenic scores aim to capture genetic risk but may miss nonlinear genetic and environmental interactions. Here, the authors show that neural networks detect limited nonlinearity and do not outperform linear models, highlighting constraints in current deep-learning approaches.

The practicality of memristor-based computation-in-memory (CIM) is limited by the specific hardware design and the manual parameters tuning process. Here, the authors develop a full-stack CIM system with both hardware and software design for improved flexibility and efficiency.

The RNA binding protein hnRNPL is recruited to chromatin by the PIK3CB promoter-transcribed non-coding RNA and forms phase-separated condensates, which activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression.

Abnormal T cell proliferation often triggers autoimmune disorders. Here the authors show that T cell-specific deficiency of the enzyme N-acetyltransferase 10 ameliorates experimental autoimmune encephalitis potentially by RACK1-mediated regulation of T cell metabolism and expansion.

Current noble metal catalysts enable efficient proton exchange membrane water electrolysis but suffer from instability. Here, the authors report an agglomeration and smelting strategy to create ruthenium-based nanoarray catalysts, enabling water electrolysis for over 500 hours at 1 A cm⁻².

Gold redox catalysis is an attractive synthetic method but challenging due to the high redox potential of Au(I)/Au(III). Now, a bidentate N-ligand-assisted gold redox catalysis using H₂O₂ as oxidant has been developed. It can be applied to various coupling reactions, including C(sp)–C(sp) cross-coupling, alkynylative cyclization and bicyclization coupling.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Base editing of the pathogenic trinucleotide repeat expansions underlying Huntington’s disease and Friedreich’s ataxia introduces repeat interruptions that reduce somatic expansion in patient cells and mice.

Drought, fires, and human activities have reversed the accumulation of live biomass carbon in the Northern Hemisphere, with total biomass shifting from a positive to a negative trend around 2016.

While entangled networks can offer improved mechanical performance in synthetic materials, these can be challenging to achieve in polymer materials. Here, the authors report a co-initiating system for fabrication of printable entangled networks.

Precise control over both sequence and chirality remains a challenge in polymer chemistry. Here sulfur–fluoride exchange and sulfur–phenolate exchange reactions are used to create chiral oligosulfonimidates with tunable sulfur-centred chirality. This strategy enables precise three-dimensional structural control over oligomers and polymers, marking a step towards fully nature-mimicking macromolecules.