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A facile light-triggered doping strategy involving a series of inactive photoactivable dopants is described that facilitates tunable regionally controlled n-doping of organic semiconductors, resulting in stable patterning of the doping profile at record high resolutions.

Visible light-induced glycosylation reactions are achieved by either photoactivating a photosensitizer or using a stoichiometric activator, while glycosylation via a photoactive glycosyl donor was so far not reported. In this study, the authors develop a photosensitizer free visible-light-mediated glycosylation approach using photoactive 2-glycosyloxy tropone as the donor, obtaining a wide range of O-glycosides or oligosaccharides.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

Although most patients achieve complete response after standard-of-care treatment, residual disease in patients with nasopharyngeal carcinoma is associated with poor prognosis. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus capecitabine for patients with residual nasopharyngeal carcinoma.

While the conversion of CO₂ to high-value products provides a promising means to remove and utilize atmospheric carbon, few materials can do so without wasteful, sacrificial reagents. Here, authors prepare single-atom Co on Bi₃O₄Br nanosheets as CO₂ reduction catalysts using water and light.

A Janus photocatalytic structure can orient and move either towards or away from an external light source, mimicking the behaviour of phototactic microorganisms.

Fault-tolerant manipulation of quantum bits is demonstrated experimentally on an eight-photon cluster state using topological error correction.

Solid-state pressure sensors have performance limitations in liquid environments. Here, the authors design a pressure sensor using solid–liquid–liquid–gas multiphasic interfaces where a trapped air layer modulates capacitance changes with pressure to achieve near-friction-free contact line motions for near-ideal pressure sensing.

Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.

Implanted bioelectronic devices have proven useful for health sensing and therapy, while the interconnection of distributed implants remains challenging. Here, the authors demonstrate direct implant-to-implant wireless networking at the scale of the human body using metamaterial textiles.

Innate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.

Genome structural variation can play an important functional role in phenotypic diversity. Here the authors use the SCRaMbLE system on a ring synthetic chromosome V to generate complex rearrangements distinct from a rearranged linear chromosome.

TRPCs, nonselective cation channels, are involved in cardiac contraction and conduction. Here, the authors show that Trpc1/6 deficiency or pharmacological inhibition improves endotoxemic cardiac dysfunction and prolongs survival by prominently suppressing cardiac inflammation and ER Ca²⁺ release.

The conductivity of protonic ceramic electrolytes for fuel cells is unsatisfactory due to poor sintering. Here, the authors report the adverse effects of dynamic Y3+ displacement on high-temperature membrane sintering and propose a new strategy for pre-doping Y into A-site to inhibit its further displacement.

This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.

Electronic textiles should maintain performance against repeated mechanical, thermal and chemical stresses during daily activities. Here, authors demonstrate digital embroidery of robust liquid metal-based fibres with wireless functionalities.

We discovered that liquid metal endowing negative mixing enthalpy with other elements could provide a stable thermodynamic condition and act as a desirable dynamic mixing reservoir, realizing the synthesis of high-entropy alloy nanoparticles.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

Legumain is a protease found expressed in tumour cells and may be useful in the specific targeting of chemotherapeutics to tumour cells. Here, the authors design nanoparticles that are loaded with doxorubicin and contain a legumain cleavage site; once the nanoparticles enter tumour cells legumain activity results in the release of doxorubicin.

Hepatitis B infection is a risk factor for hepatocellular carcinoma. Here, the authors characterise viral infection in a cohort of hepatocellular carcinoma patients and find viral integration is more frequent in males than females.

Tessa, a Bayesian model, integrates TCR sequencing data with gene expression data to analyze the effect of the TCR repertoire on T cell functionality.

The ability to direct microwimmers along a particular trajectory is advantageous for targeted drug delivery and manufacturing at the microscale. Here Zheng et al. use different types of light-absorbing dyes to enable selective activation of different microswimmers independently from each other.

Electrophoretic microswimmers aren’t well suited to function in vivo because electric-field screening reduces their speed in higher ionic-strength solutions. Here the authors propose a microswimmer that exploits high surface conductance to improve this ion tolerance to enable operation in a high salt environment.

RIG-I-MAVS signalling pathway is involved in mediating antiviral response to RNA viruses. Here the authors report that insulin receptor tyrosine kinase substrate (IRTKS) mediates MAVS degradation and thus acts as a negative regulator of the innate antiviral response.

The SCRaMbLE system integrated into Sc2.0’s synthetic yeast chromosome project allows rapid strain evolution. Here the authors use a genetic logic gate to control induction of recombination in a haploid and diploid yeast carrying synthetic chromosomes.

Through a cross-cultural study and two historical studies, Fu et al. examined the relationship between pathogen severity and semantic space. They observed that pathogen stress was associated with sensorially oriented semantic processing.

Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors identify two independent associations within the MHC region and one new susceptibility locus on chromosome 6q27, which contains the genes RNASET2, FGFR1OP and CCR6.