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Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

Urbanization and changing climate affect humans as well as our scourges. Focusing on Jiangsu Province, China, this study finds that scrub typhus, a bacterial vector-borne disease associated with the tropics, is expanding in temperate urban settings.

Limited improvement of systemic therapy has been achieved in first line treatment for advanced Biliary tract cancer (BTC). In this randomized phase 2 trial on BTC, the combination of sintilimab, anlotinib, and gemcitabine/cisplatin demonstrated an improvement in progression - free survival (PFS) and objective response rate (ORR) while reducing the risk of disease progression compared to chemotherapy monotherapy.

A strategy is reported that improves the performance and lifetime of lithium-ion batteries by adding organic Li salt after assembly, which decomposes during cell formation, liberating Li ions and expelling organic ligands as gases.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

This study demonstrates how the mesostructure of nanoporous carbon electrodes influences ion dynamics, providing mechanistic insights and strategies for the technological advancement of fast-charging electrochemical energy storage systems.

Enhancing rejection of small, neutral organic contaminants by reverse osmosis (RO) membrane is crucial for safe water supply. Here, authors report an amphiphilic nanowire-assisted monomer shuttling strategy that markedly improves the contaminant removal while simultaneously enhanced water permeance.

Here the authors use genetic mutations to alter TCR signal strength and clonal selection of exhausted CD8⁺ T cells. They implicate CARD11 signaling as a sensor of this TCR signal strength and as a regulator of antitumor function in exhausted T cells that might be targeted to enhance cancer immunotherapies.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

Macrophage-augmented organoids integrate macrophages into organoids that are cultured from human liver tissue for analysis of immune responses during three different viral infections.

Solvent engineering by the addition of 1,4-butane sultone in a perovskite precursor solution simultaneously enhances the crystallization of the perovskite and passivates defects, resulting in a power conversion efficiency of 26.5%.

The relationship between Li-ion concentration and Li deposition remains an issue to be addressed. Here the authors show that stimulated Raman scattering microscopy offers insight into the concentration evolution and its impact on the dendrite growth, which is not possible by existing techniques.

A p-block metal octoate additive in carbonate electrolytes enables the reversible plating/stripping of alkali metal in anode-free batteries by forming a protective layer with a preferentially adsorbed octoate moiety and uniformly plated p-block metal.

The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify that disrupting MBTPS1 in tumor cells upregulates STAT1-transcribed chemokines, promotes CXCR3⁺ CD8 T cells infiltration and potentiates anti-PD-1 therapy.

TGF-β family cytokines control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Here the authors identify an inner nuclear membrane phosphatase complex that dephosphorylates R-SMADs to inactivate TGF-β signaling.

Zhe Meng and co-authors demonstrate the feasibility of synergetic pyrolysis of lithium-ion battery cathode materials with PET plastic for recovering Li and transition metals. They demonstrate a high recovery ratio and energy efficiency.

A LaCl₃-based lithium superionic conductor is developed that has excellent interfacial compatibility with lithium metal electrodes, with its optimized Li_0.388Ta_0.238La_0.475Cl₃ electrolyte exhibiting good Li⁺ conductivity and low activation energy.

The use of Raman spectroscopy in biochemical applications has been hindered by several limitations. Here, the authors present a fiber-array Raman engine, termed FIRE. This tool features a dynamic single-channel photon-counting detector and is used for full Raman spectral imaging in biological samples and whole organisms.

This Review establishes a comprehensive set of permeance–selectivity relationships for thin-film composite membranes on the removal and fractionation of different solutes and provides valuable strategies for enhancing the performance of membrane systems through both material-level and system-level optimizations.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Electrochemical oxygen removal holds great potential for food preservation, but high costs and limited durability limit its adoption. Here, the authors report a membrane-free, gravity-driven reactor, providing a cost-effective, durable solution for long-term operation in household food preservation.

Despite tremendous progress in the development of LiS batteries, their performance at the full-cell level is not as competitive as state-of-the-art Li-ion batteries. Here the authors report a full-cell architecture making use of a hybrid intercalation-conversion cathode, enabling both high volumetric and gravimetric energy densities.

To increase the efficiency, brightness and stability of next-generation light-emitting diodes (LEDs), the microstructure of CsPbI_3-xBr_x metal-halide perovskite, a good pure-red emitter, was altered to fix hole leakage, which was identified as decreasing efficiencies in overworked LEDs.

Charging at high voltages in principle makes batteries energy dense, but this is often achieved at the cost of the cycling stability. Here the authors design a sulfonamide-based electrolyte to enable a Li metal battery with a state-of-the-art cathode at an ultra-high voltage of 4.7 V while maintaining cyclability.

Although germanium shares similar chemical properties with silicon, synthesizing chiral germanium centers has proven significantly more challenging. Here, the authors use deborylative alkylation of germanium chlorides and copper-catalyzed diol desymmetrization to transform simple germanium tetrachloride into a chiral germanium center in four steps.

Semiconductor polymers containing selenophene in their backbones and immunomodulatory groups in their side chains enable the fabrication of implantable bioelectronic devices with enhanced immune compatibility and low foreign-body response.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

Vanadium pentoxide is considered a promising lithium battery electrode, but suffers from poor rate capability and cyclability. Here, the authors synthesize graphene-modified nanostructured vanadium pentoxide and show significant improvement in rate performance and cycle life.

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

Organic co-crystals are useful in the fabrication of functional materials, but it is challenging to achieve structural diversity of co-crystals. Here, the authors report nine sets of macrocycle cocrystals with diverse structures and stoichiometric ratios giving different luminescence properties.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

The assembly and folding of the adenovirus capsid protein hexon require the viral-encoded chaperone 100K. Here, the authors report the cryo-EM structure of 100K in complex with a partially folded hexon, providing insights into adenovirus capsid assembly.

The complete biosynthetic pathway of Prim-O-Glucosylcimifugin and 5-O-Methylvisamminoside in Saposhnikovia divaricata is resolved and their de novo biosynthesis is reconstructed in Nicotiana benthamiana leaves. The evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants is further analyzed.

Cytology is commonly used for cervical cancer screening or triage. Here, the authors used deep learning to develop a liquid-based cytology screening approach to detect cervical cancer in both community and hospital-based settings.